Jin LI, Hui LI, QI XIONG LI, Ying XUE

Repaglinide inhibits cyclosporine A-induced renal tubular toxicity by affecting apoptosis and Bax and Bcl-2 expression

Öz Background/aim: Repaglinide (RG) is a prandial glucose regulator used for the treatment of type 2 diabetes. Our recent study showed that RG plays an important role in cyclosporine A (CsA)-induced nephrotoxicity through its antioxidant properties. However, it is not known whether or not RG has any protective effect on CsA-induced renal tubular toxicity by affecting apoptosis and expression of apoptosis-associated protein. The purpose of this study was to investigate the effects of RG on CsA-induced renal tubule apoptosis and Bax and Bcl-2 protein expression in rats. Materials and methods: Forty male Sprague Dawley rats weighing 250-300 g were randomly divided into four groups: administrations of olive oil (control, per os (PO)), CsA (30 mg/kg in olive oil, subcutaneous (SC)), and RG (0.2 or 0.4 mg/kg, PO) plus CsA (30 mg/kg in olive oil, SC) every day for 15 days. Results: Our results showed that SC administration of CsA (30 mg/kg) to rats produced marked injury and apoptosis, elevation of Bax protein expression, and inhibition of Bcl-2 protein expression in the kidneys, which were reversed significantly by oral administration of RG (0.2 or 0.4 mg/kg). Conclusion: The findings of our study indicate that RG may play an important role in protecting the kidneys through inhibiting apoptosis, Bax, and Bcl-2 protein expression.

Anahtar Kelimeler:

Repaglinide, cyclosporine A, apoptosis, Bax and Bcl-2 expression, renal, rat

Tam Metin

Kaynak Göster

Bibtex	`@ { tbtkmedical576745, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2018}, volume = {48}, pages = {880 - 885}, doi = {}, title = {Repaglinide inhibits cyclosporine A-induced renal tubular toxicity by affecting apoptosis and Bax and Bcl-2 expression}, key = {cite}, author = {Lı, Jin and Lı, Hui and Lı, QI XIONG and Xue, Ying} }`
APA	Lı, J , Lı, H , Lı, Q , Xue, Y . (2018). Repaglinide inhibits cyclosporine A-induced renal tubular toxicity by affecting apoptosis and Bax and Bcl-2 expression . Turkish Journal of Medical Sciences , 48 (4) , 880-885 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45702/576745
MLA	Lı, J , Lı, H , Lı, Q , Xue, Y . "Repaglinide inhibits cyclosporine A-induced renal tubular toxicity by affecting apoptosis and Bax and Bcl-2 expression" . Turkish Journal of Medical Sciences 48 (2018 ): 880-885 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45702/576745>
Chicago	Lı, J , Lı, H , Lı, Q , Xue, Y . "Repaglinide inhibits cyclosporine A-induced renal tubular toxicity by affecting apoptosis and Bax and Bcl-2 expression". Turkish Journal of Medical Sciences 48 (2018 ): 880-885
RIS	TY - JOUR T1 - Repaglinide inhibits cyclosporine A-induced renal tubular toxicity by affecting apoptosis and Bax and Bcl-2 expression AU - Jin Lı , Hui Lı , QI XIONG Lı , Ying Xue Y1 - 2018 PY - 2018 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 880 EP - 885 VL - 48 IS - 4 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote	%0 Turkish Journal of Medical Sciences Repaglinide inhibits cyclosporine A-induced renal tubular toxicity by affecting apoptosis and Bax and Bcl-2 expression %A Jin Lı , Hui Lı , QI XIONG Lı , Ying Xue %T Repaglinide inhibits cyclosporine A-induced renal tubular toxicity by affecting apoptosis and Bax and Bcl-2 expression %D 2018 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 48 %N 4 %R %U
ISNAD	Lı, Jin , Lı, Hui , Lı, QI XIONG , Xue, Ying . "Repaglinide inhibits cyclosporine A-induced renal tubular toxicity by affecting apoptosis and Bax and Bcl-2 expression". Turkish Journal of Medical Sciences 48 / 4 (Ağustos 2018): 880-885 .
AMA	Lı J , Lı H , Lı Q , Xue Y . Repaglinide inhibits cyclosporine A-induced renal tubular toxicity by affecting apoptosis and Bax and Bcl-2 expression. Turkish Journal of Medical Sciences. 2018; 48(4): 880-885.
Vancouver	Lı J , Lı H , Lı Q , Xue Y . Repaglinide inhibits cyclosporine A-induced renal tubular toxicity by affecting apoptosis and Bax and Bcl-2 expression. Turkish Journal of Medical Sciences. 2018; 48(4): 880-885.
IEEE	J. Lı , H. Lı , Q. Lı ve Y. Xue , "Repaglinide inhibits cyclosporine A-induced renal tubular toxicity by affecting apoptosis and Bax and Bcl-2 expression", Turkish Journal of Medical Sciences, c. 48, sayı. 4, ss. 880-885, Ağu. 2018