Polycythemia vera: diagnosis, clinical course, and current management

Öz Very important developments related to polycythemia vera (PV) have occurred during the last two decades. The discovery of Janus kinase (JAK) 2 mutations has changed both the diagnosis and clinical management of PV. Currently JAK2 molecular testing is essential in the diagnostic work-up and JAK2 mutation positivity is a major diagnostic criterion. The discovery of JAK2 mutations suggested that abnormal JAK-STAT signaling was a pivotal feature in the pathogenesis of Philadelphia-negative myeloproliferative neoplasms. This idea led to the development of JAK inhibitors. Currently ruxolitinib, a JAK1/JAK2 inhibitor, is also approved for PV patients with hydroxyurea resistance or intolerance. International collaborations have made it possible to describe disease characteristics and evolution better. Presently it is possible to quantify the symptomatic burden of the disease and to estimate prognosis. In spite of these developments, management of PV still largely depends on estimation of thromboembolic risk and trying to decrease the risk with or without cytoreductive medications. Different approaches have been proposed by international disease experts for the diagnosis, thromboembolic risk estimation, and drug selection. This paper aims to review clinical aspects of PV and propose a management algorithm. The authors also point to still unresolved questions and unmet needs in diagnosis and management.

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Bibtex @araştırma makalesi { tbtkmedical576708, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2018}, volume = {48}, pages = {698 - 710}, doi = {}, title = {Polycythemia vera: diagnosis, clinical course, and current management}, key = {cite}, author = {Büyükaşık, Yahya and Ali, Ridvan and Ar, Muhlis Cem and Turgut, Mehmet and Yavuz, Akif Selim and Saydam, Güray} }
APA Büyükaşık, Y , Ali, R , Ar, M , Turgut, M , Yavuz, A , Saydam, G . (2018). Polycythemia vera: diagnosis, clinical course, and current management . Turkish Journal of Medical Sciences , 48 (4) , 698-710 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45702/576708
MLA Büyükaşık, Y , Ali, R , Ar, M , Turgut, M , Yavuz, A , Saydam, G . "Polycythemia vera: diagnosis, clinical course, and current management" . Turkish Journal of Medical Sciences 48 (2018 ): 698-710 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45702/576708>
Chicago Büyükaşık, Y , Ali, R , Ar, M , Turgut, M , Yavuz, A , Saydam, G . "Polycythemia vera: diagnosis, clinical course, and current management". Turkish Journal of Medical Sciences 48 (2018 ): 698-710
RIS TY - JOUR T1 - Polycythemia vera: diagnosis, clinical course, and current management AU - Yahya Büyükaşık , Ridvan Ali , Muhlis Cem Ar , Mehmet Turgut , Akif Selim Yavuz , Güray Saydam Y1 - 2018 PY - 2018 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 698 EP - 710 VL - 48 IS - 4 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Polycythemia vera: diagnosis, clinical course, and current management %A Yahya Büyükaşık , Ridvan Ali , Muhlis Cem Ar , Mehmet Turgut , Akif Selim Yavuz , Güray Saydam %T Polycythemia vera: diagnosis, clinical course, and current management %D 2018 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 48 %N 4 %R %U
ISNAD Büyükaşık, Yahya , Ali, Ridvan , Ar, Muhlis Cem , Turgut, Mehmet , Yavuz, Akif Selim , Saydam, Güray . "Polycythemia vera: diagnosis, clinical course, and current management". Turkish Journal of Medical Sciences 48 / 4 (Ağustos 2018): 698-710 .
AMA Büyükaşık Y , Ali R , Ar M , Turgut M , Yavuz A , Saydam G . Polycythemia vera: diagnosis, clinical course, and current management. Turkish Journal of Medical Sciences. 2018; 48(4): 698-710.
Vancouver Büyükaşık Y , Ali R , Ar M , Turgut M , Yavuz A , Saydam G . Polycythemia vera: diagnosis, clinical course, and current management. Turkish Journal of Medical Sciences. 2018; 48(4): 698-710.
IEEE Y. Büyükaşık , R. Ali , M. Ar , M. Turgut , A. Yavuz ve G. Saydam , "Polycythemia vera: diagnosis, clinical course, and current management", Turkish Journal of Medical Sciences, c. 48, sayı. 4, ss. 698-710, Ağu. 2018

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