Sevim GÖNEN, Murat DİZBAY, Hüsnü Oğuz SÖYLEMEZOĞLU

Investigation of human leukocyte antigen in osteoarticular brucellosis

Öz Background/aim: To determine the relationship between human leukocyte antigen (HLA) antigens and osteoarticular brucellosis by evaluating HLA Class I and II antigens in control subjects and patients developing osteoarticular brucellosis in Turkey.Materials and methods: The study included 28 patients with osteoarticular involvement diagnosed with brucellosis and 100 controls. The HLA Class I and II antigens were studied in isolated DNA samples using sequence-specific oligonucleotide procedure.Results: The mean age of the 28 patients and 100 controls was 42.3 $\pm$ 20.2 years and 50.1 $\pm$ 16.3 years, respectively. When the frequency of HLA Class I was examined, HLA-A*02 and HLA-B*27 antigens were detected in 50% and 28.57% of the patients, respectively. However, there was no significant difference when compared to the control group. Among the HLA Class I antigens, HLA-Cw*10 was determined in 35.71% of the patients and 17% of the controls; the difference was significant (P = 0.039).Conclusion: In the development of brucellosis, the frequency of HLA-Cw*10 among HLA Class I antigens was observed to be increased, and HLA-Cw*10 was considered likely to cause predisposition to brucellosis. Further studies to be performed on a higher number of patients and controls could demonstrate that genetic factors play a role in the diagnosis of osteoarticular brucellosis.

Anahtar Kelimeler:

Brucellosis, human leukocyte antigen, polymerase chain reaction

Tam Metin

Kaynak Göster

Bibtex	`@ { tbtkmedical576381, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2017}, volume = {47}, pages = {1505 - 1508}, doi = {}, title = {Investigation of human leukocyte antigen in osteoarticular brucellosis}, key = {cite}, author = {Gönen, Sevim and Dizbay, Murat and Söylemezoğlu, Hüsnü Oğuz} }`
APA	Gönen, S , Dizbay, M , Söylemezoğlu, H . (2017). Investigation of human leukocyte antigen in osteoarticular brucellosis . Turkish Journal of Medical Sciences , 47 (5) , 1505-1508 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45689/576381
MLA	Gönen, S , Dizbay, M , Söylemezoğlu, H . "Investigation of human leukocyte antigen in osteoarticular brucellosis" . Turkish Journal of Medical Sciences 47 (2017 ): 1505-1508 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45689/576381>
Chicago	Gönen, S , Dizbay, M , Söylemezoğlu, H . "Investigation of human leukocyte antigen in osteoarticular brucellosis". Turkish Journal of Medical Sciences 47 (2017 ): 1505-1508
RIS	TY - JOUR T1 - Investigation of human leukocyte antigen in osteoarticular brucellosis AU - Sevim Gönen , Murat Dizbay , Hüsnü Oğuz Söylemezoğlu Y1 - 2017 PY - 2017 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1505 EP - 1508 VL - 47 IS - 5 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote	%0 Turkish Journal of Medical Sciences Investigation of human leukocyte antigen in osteoarticular brucellosis %A Sevim Gönen , Murat Dizbay , Hüsnü Oğuz Söylemezoğlu %T Investigation of human leukocyte antigen in osteoarticular brucellosis %D 2017 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 47 %N 5 %R %U
ISNAD	Gönen, Sevim , Dizbay, Murat , Söylemezoğlu, Hüsnü Oğuz . "Investigation of human leukocyte antigen in osteoarticular brucellosis". Turkish Journal of Medical Sciences 47 / 5 (Ekim 2017): 1505-1508 .
AMA	Gönen S , Dizbay M , Söylemezoğlu H . Investigation of human leukocyte antigen in osteoarticular brucellosis. Turkish Journal of Medical Sciences. 2017; 47(5): 1505-1508.
Vancouver	Gönen S , Dizbay M , Söylemezoğlu H . Investigation of human leukocyte antigen in osteoarticular brucellosis. Turkish Journal of Medical Sciences. 2017; 47(5): 1505-1508.
IEEE	S. Gönen , M. Dizbay ve H. Söylemezoğlu , "Investigation of human leukocyte antigen in osteoarticular brucellosis", Turkish Journal of Medical Sciences, c. 47, sayı. 5, ss. 1505-1508, Eki. 2017