Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases

Öz Background/aim: Intralesional recombinant epidermal growth factor (EGF) is a new treatment approach for diabetic foot ulcer, approved in 2006. EGF therapy is given as an adjunct to the standard treatment regimen of antibiotics, surgery, and hyperbaric oxygen. EGF accelerates the healing of diabetic foot ulcers and reduces healing time. This single-center study was conducted to evaluate the outcomes of intralesional EGF therapy in patients with diabetic foot ulcers.Materials and methods: We present the data of the follow-up patients treated in our clinics. Fifteen patients with diabetic foot ulcers or infections, who had been followed up and treated in our clinics, were included in this retrospective study. All patients were administered intralesional injections of 75 μg of EGF after treatment for infection on their diabetic foot ulcers, three times a week on alternate days. The patients were monitored with respect to treatment response and side effects of EGF.Results: Thirteen patients (86.7%) developed new granulation tissue, 10 patients (66.7%) had complete wound closure, and three patients (20%) showed partial wound closure. No serious side effects requiring discontinuation of EGF therapy were observed. A total of twenty-one bacterial agents were isolated in thirteen patients, and no bacterial growth was observed in the tissue cultures of two patients. Pseudomonas aeruginosa was the most common isolated infectious agent in the tissue cultures (n: 6, 28%). Conclusion: Intralesional injection of EGF on top of the standard treatment regimen appears to be a useful adjuvant therapy option in selected patients.

Kaynak Göster

Bibtex @ { tbtkmedical576379, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2017}, volume = {47}, pages = {1500 - 1504}, doi = {}, title = {Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases}, key = {cite}, author = {Taşbakan, Meltem and Şimşir, İlgin Yildirim and Mermer, Sinan and Uysal, Serhat and Öztürk, Anil Murat and Çetinkalp, Şevki} }
APA Taşbakan, M , Şimşir, İ , Mermer, S , Uysal, S , Öztürk, A , Çetinkalp, Ş . (2017). Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases . Turkish Journal of Medical Sciences , 47 (5) , 1500-1504 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45689/576379
MLA Taşbakan, M , Şimşir, İ , Mermer, S , Uysal, S , Öztürk, A , Çetinkalp, Ş . "Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases" . Turkish Journal of Medical Sciences 47 (2017 ): 1500-1504 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45689/576379>
Chicago Taşbakan, M , Şimşir, İ , Mermer, S , Uysal, S , Öztürk, A , Çetinkalp, Ş . "Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases". Turkish Journal of Medical Sciences 47 (2017 ): 1500-1504
RIS TY - JOUR T1 - Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases AU - Meltem Taşbakan , İlgin Yildirim Şimşir , Sinan Mermer , Serhat Uysal , Anil Murat Öztürk , Şevki Çetinkalp Y1 - 2017 PY - 2017 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1500 EP - 1504 VL - 47 IS - 5 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases %A Meltem Taşbakan , İlgin Yildirim Şimşir , Sinan Mermer , Serhat Uysal , Anil Murat Öztürk , Şevki Çetinkalp %T Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases %D 2017 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 47 %N 5 %R %U
ISNAD Taşbakan, Meltem , Şimşir, İlgin Yildirim , Mermer, Sinan , Uysal, Serhat , Öztürk, Anil Murat , Çetinkalp, Şevki . "Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases". Turkish Journal of Medical Sciences 47 / 5 (Ekim 2017): 1500-1504 .
AMA Taşbakan M , Şimşir İ , Mermer S , Uysal S , Öztürk A , Çetinkalp Ş . Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases. Turkish Journal of Medical Sciences. 2017; 47(5): 1500-1504.
Vancouver Taşbakan M , Şimşir İ , Mermer S , Uysal S , Öztürk A , Çetinkalp Ş . Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases. Turkish Journal of Medical Sciences. 2017; 47(5): 1500-1504.
IEEE M. Taşbakan , İ. Şimşir , S. Mermer , S. Uysal , A. Öztürk ve Ş. Çetinkalp , "Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases", Turkish Journal of Medical Sciences, c. 47, sayı. 5, ss. 1500-1504, Eki. 2017

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