Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and inflammation

Öz Background/aim: Hyperoxia- and inflammation-induced lung injury is an important cause of the development of bronchopulmonary dysplasia (BPD) in premature infants. We aimed to ascertain the beneficial effects of ginger (Zingiber officinale) on rat pups exposed to hyperoxia and inflammation. Materials and methods: Thirty-six newborn Wistar rats were randomly divided into 3 groups as the hyperoxia (95% O2) + lipopolysaccharide (LPS) group, the hyperoxia + LPS + ginger-treated group, and the control/no treatment group (21% O2). Pups in the hyperoxia + LPS + ginger group were administered oral ginger at a dose of 1000 mg/kg daily during the study period. Histopathologic, immunochemical (SMA and lamellar body), and biochemical evaluations including total antioxidant status (TAS), total oxidant status (TOS), malondialdehyde (MDA), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1ß), interleukin-6 (IL-6), and caspase-3 activities were performed. Results: Better weight gain and survival rates were shown in the hyperoxia + LPS + ginger group (P < 0.05). In the histopathologic and immunochemical evaluation, severity of lung damage was significantly reduced in the hyperoxia + LPS + ginger group, as well as decreased apoptosis (ELISA for caspase-3) (P < 0.05). Tissue TAS levels were significantly protected, and TOS, MDA, and MPO levels were significantly lower in the hyperoxia + LPS + ginger group (P < 0.05). Tissue TNF-α, IL-1ß, and IL-6 concentrations were significantly decreased in the ginger-treated group (P < 0.05). Conclusion: Ginger efficiently reduced the lung damage and protected the lungs from severe damage due to hyperoxia and inflammation. Therefore, ginger may be an alternative option for the treatment of BPD.

Kaynak Göster

Bibtex @ { tbtkmedical576751, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2018}, volume = {48}, pages = {892 - 900}, doi = {}, title = {Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and inflammation}, key = {cite}, author = {Çifci, ATİLLA and Tayman, CÜNEYT and Yakut, HALİL İBRAHİM and Halil, Halit and Çakır, ESRA and Çakır, Ufuk and Aydemir, SALİH} }
APA Çifci, A , Tayman, C , Yakut, H , Halil, H , Çakır, E , Çakır, U , Aydemir, S . (2018). Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and inflammation . Turkish Journal of Medical Sciences , 48 (4) , 892-900 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45702/576751
MLA Çifci, A , Tayman, C , Yakut, H , Halil, H , Çakır, E , Çakır, U , Aydemir, S . "Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and inflammation" . Turkish Journal of Medical Sciences 48 (2018 ): 892-900 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45702/576751>
Chicago Çifci, A , Tayman, C , Yakut, H , Halil, H , Çakır, E , Çakır, U , Aydemir, S . "Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and inflammation". Turkish Journal of Medical Sciences 48 (2018 ): 892-900
RIS TY - JOUR T1 - Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and inflammation AU - ATİLLA Çifci , CÜNEYT Tayman , HALİL İBRAHİM Yakut , Halit Halil , ESRA Çakır , Ufuk Çakır , SALİH Aydemir Y1 - 2018 PY - 2018 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 892 EP - 900 VL - 48 IS - 4 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and inflammation %A ATİLLA Çifci , CÜNEYT Tayman , HALİL İBRAHİM Yakut , Halit Halil , ESRA Çakır , Ufuk Çakır , SALİH Aydemir %T Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and inflammation %D 2018 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 48 %N 4 %R %U
ISNAD Çifci, ATİLLA , Tayman, CÜNEYT , Yakut, HALİL İBRAHİM , Halil, Halit , Çakır, ESRA , Çakır, Ufuk , Aydemir, SALİH . "Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and inflammation". Turkish Journal of Medical Sciences 48 / 4 (Ağustos 2018): 892-900 .
AMA Çifci A , Tayman C , Yakut H , Halil H , Çakır E , Çakır U , Aydemir S . Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and inflammation. Turkish Journal of Medical Sciences. 2018; 48(4): 892-900.
Vancouver Çifci A , Tayman C , Yakut H , Halil H , Çakır E , Çakır U , Aydemir S . Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and inflammation. Turkish Journal of Medical Sciences. 2018; 48(4): 892-900.
IEEE A. Çifci , C. Tayman , H. Yakut , H. Halil , E. Çakır , U. Çakır ve S. Aydemir , "Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and inflammation", Turkish Journal of Medical Sciences, c. 48, sayı. 4, ss. 892-900, Ağu. 2018

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