Epidemiology and analysis of invasive fungal infections in patients withhematological malignancies: a single-center real-life experience

Öz Background/aim: Invasive fungal infection (IFI) causes morbidity and mortality among patients with hematological malignancies. We evaluated the incidence and treatment characteristics of IFIs between October 2012 and December 2013. Materials and methods: Patients who received chemotherapy or stem cell transplantation were retrospectively evaluated. Fungal infections were classified according to EORTC criteria.Results: Prophylaxis and antifungal therapy were given in 30.5% and 23.6% of 522 chemotherapy courses, respectively. The incidence of proven/probable IFI was 6.7%. The incidence of IFI among patients who received prophylaxis was significantly higher than among those who did not receive it (11.3% vs. 4.6%, P = 0.005). There was no significant difference between patients who received mold-active and no mold-active prophylaxis (P = 0.098). The most common single agent therapy and causative pathogen was liposomal amphotericin B (57.1%) and Aspergillus (n = 5), respectively. IFI-attributable mortality rate was 14.2% in 6 weeks.Conclusion: The IFI incidence and mortality rate were similar to that reported in the literature. The IFI rate was higher in the group using prophylaxis, as this is a high-risk group. Although the IFI rate was not significantly different between groups using prophylaxis, patients should be followed closely for the effective use of posaconazole prophylaxis.

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Bibtex @ { tbtkmedical576385, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2017}, volume = {47}, pages = {1535 - 1542}, doi = {}, title = {Epidemiology and analysis of invasive fungal infections in patients withhematological malignancies: a single-center real-life experience}, key = {cite}, author = {Soyer, Nur and Ünal, Hatice Demet Kiper and Vural, Filiz and Şahin, Fahri and Töbü, Mahmut and Dönmez, Ayhan and Tombuloğlu, Murat and Arda, Bilgin and Saydam, Güray} }
APA Soyer, N , Ünal, H , Vural, F , Şahin, F , Töbü, M , Dönmez, A , Tombuloğlu, M , Arda, B , Saydam, G . (2017). Epidemiology and analysis of invasive fungal infections in patients withhematological malignancies: a single-center real-life experience . Turkish Journal of Medical Sciences , 47 (5) , 1535-1542 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45689/576385
MLA Soyer, N , Ünal, H , Vural, F , Şahin, F , Töbü, M , Dönmez, A , Tombuloğlu, M , Arda, B , Saydam, G . "Epidemiology and analysis of invasive fungal infections in patients withhematological malignancies: a single-center real-life experience" . Turkish Journal of Medical Sciences 47 (2017 ): 1535-1542 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45689/576385>
Chicago Soyer, N , Ünal, H , Vural, F , Şahin, F , Töbü, M , Dönmez, A , Tombuloğlu, M , Arda, B , Saydam, G . "Epidemiology and analysis of invasive fungal infections in patients withhematological malignancies: a single-center real-life experience". Turkish Journal of Medical Sciences 47 (2017 ): 1535-1542
RIS TY - JOUR T1 - Epidemiology and analysis of invasive fungal infections in patients withhematological malignancies: a single-center real-life experience AU - Nur Soyer , Hatice Demet Kiper Ünal , Filiz Vural , Fahri Şahin , Mahmut Töbü , Ayhan Dönmez , Murat Tombuloğlu , Bilgin Arda , Güray Saydam Y1 - 2017 PY - 2017 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1535 EP - 1542 VL - 47 IS - 5 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Epidemiology and analysis of invasive fungal infections in patients withhematological malignancies: a single-center real-life experience %A Nur Soyer , Hatice Demet Kiper Ünal , Filiz Vural , Fahri Şahin , Mahmut Töbü , Ayhan Dönmez , Murat Tombuloğlu , Bilgin Arda , Güray Saydam %T Epidemiology and analysis of invasive fungal infections in patients withhematological malignancies: a single-center real-life experience %D 2017 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 47 %N 5 %R %U
ISNAD Soyer, Nur , Ünal, Hatice Demet Kiper , Vural, Filiz , Şahin, Fahri , Töbü, Mahmut , Dönmez, Ayhan , Tombuloğlu, Murat , Arda, Bilgin , Saydam, Güray . "Epidemiology and analysis of invasive fungal infections in patients withhematological malignancies: a single-center real-life experience". Turkish Journal of Medical Sciences 47 / 5 (Ekim 2017): 1535-1542 .
AMA Soyer N , Ünal H , Vural F , Şahin F , Töbü M , Dönmez A , Tombuloğlu M , Arda B , Saydam G . Epidemiology and analysis of invasive fungal infections in patients withhematological malignancies: a single-center real-life experience. Turkish Journal of Medical Sciences. 2017; 47(5): 1535-1542.
Vancouver Soyer N , Ünal H , Vural F , Şahin F , Töbü M , Dönmez A , Tombuloğlu M , Arda B , Saydam G . Epidemiology and analysis of invasive fungal infections in patients withhematological malignancies: a single-center real-life experience. Turkish Journal of Medical Sciences. 2017; 47(5): 1535-1542.
IEEE N. Soyer , H. Ünal , F. Vural , F. Şahin , M. Töbü , A. Dönmez , M. Tombuloğlu , B. Arda ve G. Saydam , "Epidemiology and analysis of invasive fungal infections in patients withhematological malignancies: a single-center real-life experience", Turkish Journal of Medical Sciences, c. 47, sayı. 5, ss. 1535-1542, Eki. 2017

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