Funda DEMİRAĞ, Aydin YILMAZ, Nilgün Yilmaz DEMİRCİ, Ülkü YILMAZ, Yurdanur ERDOĞAN

EGFR, KRAS, and BRAF mutational profiles of female patients with micropapillary predominant invasive lung adenocarcinoma

Öz Background/aim: This study aimed to analyze EGFR, KRAS, and BRAF mutations in females with micropapillary predominant invasive lung adenocarcinoma and their relationships with immunohistochemical and clinicopathological patterns.Materials and methods: A total of 15 females with micropapillary lung adenocarcinoma were selected. Mutational analysis of the EGFR, KRAS, and BRAF genes was carried out. Information regarding the demographic data, tumor size, treatment, and survival time for each patient was collated, and the predominant cell type, secondary architectural growth patterns, psammoma bodies, necrosis, and visceral pleural and angiolymphatic invasions were evaluated.Results: We identified EGFR mutation in six cases, KRAS mutation in three cases, and BRAF mutation in one case. EGFR, c-kit, VEGFR, and bcl-2 positivity was observed in ten, seven, four, and six cases, respectively. All cases were positive for VEGF (strong positivity in 11 cases and weak positivity in four cases) and bcl-2 (strong positivity in nine cases and weak positivity in six cases). Seven (46.6%) cases were positive for c-kit and 10 (66.6%) cases were positive for EGFR. Conclusion: EGFR mutation occurred at a higher incidence rate in micropapillary predominant invasive adenocarcinoma than has previously been found in conventional lung adenocarcinomas. KRAS mutation was observed as having a similar frequency to what was previously observed, but the frequency of BRAF mutation was lower than previously reported.

Anahtar Kelimeler:

BRAF, EGFR, KRAS, micropapillary dominant invasive adenocarcinoma, mutation

Tam Metin

Kaynak Göster

Bibtex	`@araştırma makalesi { tbtkmedical576360, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2017}, volume = {47}, pages = {1354 - 1361}, doi = {}, title = {EGFR, KRAS, and BRAF mutational profiles of female patients with micropapillary predominant invasive lung adenocarcinoma}, key = {cite}, author = {Demirağ, Funda and Yılmaz, Aydin and Demirci, Nilgün Yilmaz and Yılmaz, Ülkü and Erdoğan, Yurdanur} }`
APA	Demirağ, F , Yılmaz, A , Demirci, N , Yılmaz, Ü , Erdoğan, Y . (2017). EGFR, KRAS, and BRAF mutational profiles of female patients with micropapillary predominant invasive lung adenocarcinoma . Turkish Journal of Medical Sciences , 47 (5) , 1354-1361 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45689/576360
MLA	Demirağ, F , Yılmaz, A , Demirci, N , Yılmaz, Ü , Erdoğan, Y . "EGFR, KRAS, and BRAF mutational profiles of female patients with micropapillary predominant invasive lung adenocarcinoma" . Turkish Journal of Medical Sciences 47 (2017 ): 1354-1361 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45689/576360>
Chicago	Demirağ, F , Yılmaz, A , Demirci, N , Yılmaz, Ü , Erdoğan, Y . "EGFR, KRAS, and BRAF mutational profiles of female patients with micropapillary predominant invasive lung adenocarcinoma". Turkish Journal of Medical Sciences 47 (2017 ): 1354-1361
RIS	TY - JOUR T1 - EGFR, KRAS, and BRAF mutational profiles of female patients with micropapillary predominant invasive lung adenocarcinoma AU - Funda Demirağ , Aydin Yılmaz , Nilgün Yilmaz Demirci , Ülkü Yılmaz , Yurdanur Erdoğan Y1 - 2017 PY - 2017 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1354 EP - 1361 VL - 47 IS - 5 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote	%0 Turkish Journal of Medical Sciences EGFR, KRAS, and BRAF mutational profiles of female patients with micropapillary predominant invasive lung adenocarcinoma %A Funda Demirağ , Aydin Yılmaz , Nilgün Yilmaz Demirci , Ülkü Yılmaz , Yurdanur Erdoğan %T EGFR, KRAS, and BRAF mutational profiles of female patients with micropapillary predominant invasive lung adenocarcinoma %D 2017 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 47 %N 5 %R %U
ISNAD	Demirağ, Funda , Yılmaz, Aydin , Demirci, Nilgün Yilmaz , Yılmaz, Ülkü , Erdoğan, Yurdanur . "EGFR, KRAS, and BRAF mutational profiles of female patients with micropapillary predominant invasive lung adenocarcinoma". Turkish Journal of Medical Sciences 47 / 5 (Ekim 2017): 1354-1361 .
AMA	Demirağ F , Yılmaz A , Demirci N , Yılmaz Ü , Erdoğan Y . EGFR, KRAS, and BRAF mutational profiles of female patients with micropapillary predominant invasive lung adenocarcinoma. Turkish Journal of Medical Sciences. 2017; 47(5): 1354-1361.
Vancouver	Demirağ F , Yılmaz A , Demirci N , Yılmaz Ü , Erdoğan Y . EGFR, KRAS, and BRAF mutational profiles of female patients with micropapillary predominant invasive lung adenocarcinoma. Turkish Journal of Medical Sciences. 2017; 47(5): 1354-1361.
IEEE	F. Demirağ , A. Yılmaz , N. Demirci , Ü. Yılmaz ve Y. Erdoğan , "EGFR, KRAS, and BRAF mutational profiles of female patients with micropapillary predominant invasive lung adenocarcinoma", Turkish Journal of Medical Sciences, c. 47, sayı. 5, ss. 1354-1361, Eki. 2017