Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study

Öz Background/aim:Ankaferd hemostat (ABS; Ankaferd blood stopper, İstanbul, Turkey) is a prohemostatic agent affecting erythrocytes. The hemostatic action of ABS depends upon fibrinogen gamma chain, prothrombin, and red blood cells. The aim of this study was to assess the effects of ABS on erythrocyte aggregation via hemorheological analyses.Materials and methods: To measure erythrocyte aggregation, blood samples were obtained from healthy, nonsmoker volunteers who had not taken any medication in the previous 10 days. One mL of blood was placed into the laser-assisted optical rotational cell analyzer (LORCA), into the chamber formed by the gap between two concentric glass cylinders. The solution prepared with ABS and saline was added to blood in incremental amounts of 10 μL, 20 μL, 30 μL, 40 μL, 50 μL, 60 μL, 70 μL, and 100 μL. Erythrocyte aggregation was determined by laser-assisted optical rotational cell analyzer at 37 °C. Results: AMPwas found to be 17.7 ± 2.1 au in the blood without ABS, whereas it was lower in the blood with ABS. AMP was 16.0 ± 3.3 in the ABS-added blood group. RBC aggregates did not form faster when cells contacted ABS. The t t½ value was 4.6 ± 2.6 in the ABS-added blood group and 1.9 ± 0.20 in the control group. Aggregation was faster in the control group (P = 0.03). AI, which is a combination of AMP and t½, was lowered in the ABS group (48.7 ± 12.3) compared to the control group (65.8 ± 1.6) (P = 0.02). It was notable that the γIsc max (sec-1) value of the control was higher (200 ± 106) than the ABS-added blood group (141 ± 51.0). Conclusion: ABS has antierythroid aggregation effect. ABS inhibits pathological aggregation of red blood cells. Antithrombotic clinical effects of ABS may be ascribed to the antierythroid aggregan actions of the drug.

Kaynak Göster

Bibtex @ { tbtkmedical577826, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2019}, volume = {49}, pages = {356 - 360}, doi = {}, title = {Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study}, key = {cite}, author = {Çiftçiler, Rafiye and Aksu, Salih and Falkmarken, Neslihan Hacer Dikmenoğlu and Haznedaroğlu, İbrahim Celalettin} }
APA Çiftçiler, R , Aksu, S , Falkmarken, N , Haznedaroğlu, İ . (2019). Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study . Turkish Journal of Medical Sciences , 49 (1) , 356-360 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45750/577826
MLA Çiftçiler, R , Aksu, S , Falkmarken, N , Haznedaroğlu, İ . "Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study" . Turkish Journal of Medical Sciences 49 (2019 ): 356-360 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45750/577826>
Chicago Çiftçiler, R , Aksu, S , Falkmarken, N , Haznedaroğlu, İ . "Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study". Turkish Journal of Medical Sciences 49 (2019 ): 356-360
RIS TY - JOUR T1 - Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study AU - Rafiye Çiftçiler , Salih Aksu , Neslihan Hacer Dikmenoğlu Falkmarken , İbrahim Celalettin Haznedaroğlu Y1 - 2019 PY - 2019 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 356 EP - 360 VL - 49 IS - 1 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study %A Rafiye Çiftçiler , Salih Aksu , Neslihan Hacer Dikmenoğlu Falkmarken , İbrahim Celalettin Haznedaroğlu %T Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study %D 2019 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 49 %N 1 %R %U
ISNAD Çiftçiler, Rafiye , Aksu, Salih , Falkmarken, Neslihan Hacer Dikmenoğlu , Haznedaroğlu, İbrahim Celalettin . "Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study". Turkish Journal of Medical Sciences 49 / 1 (Şubat 2019): 356-360 .
AMA Çiftçiler R , Aksu S , Falkmarken N , Haznedaroğlu İ . Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study. Turkish Journal of Medical Sciences. 2019; 49(1): 356-360.
Vancouver Çiftçiler R , Aksu S , Falkmarken N , Haznedaroğlu İ . Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study. Turkish Journal of Medical Sciences. 2019; 49(1): 356-360.
IEEE R. Çiftçiler , S. Aksu , N. Falkmarken ve İ. Haznedaroğlu , "Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study", Turkish Journal of Medical Sciences, c. 49, sayı. 1, ss. 356-360, Şub. 2019

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