Effect of inhaled steroids on clinical and inflammatoryparameters in children with cystic fibrosis

Öz Background/aim: The effectiveness of inhaled corticosteroids (ICSs) in cystic fibrosis (CF) is controversial. The aim of this study was to investigate the effect of an ICS on bronchial hyperreactivity (BHR), oxidative status, and clinical and inflammatory parameters in CF patients. Materials and methods: CF patients were randomized to receive either 2 mg/day nebulized budesonide or 0.9% normal saline as placebo for 8 weeks. Results: Twenty-nine CF patients (mean age: 10.5 $\pm$ 2.9 years) were enrolled in the study. There was no statistically significant difference between the two groups at the end of 8 weeks in terms of symptoms, pulmonary function, BHR, oxidative burst, hs-CRP, or ESR. Although there was a significant decrease in malondialdehyde levels in both groups, there was no difference between the two groups. Percentage of neutrophils in the sputum of patients decreased in the budesonide group (P = 0.006). Although sputum IL-8 levels significantly increased in both groups, there was no statistically significant difference between the two groups. Conclusion: Although there was a significant decrease in the percentage of neutrophils in sputum with budesonide, 8 weeks of 2 mg/day nebulized budesonide was not effective in terms of BHR, oxidative status, or clinical and other inflammatory parameters in children with CF.

Kaynak Göster

Bibtex @ { tbtkmedical576370, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2017}, volume = {47}, pages = {1432 - 1440}, doi = {}, title = {Effect of inhaled steroids on clinical and inflammatoryparameters in children with cystic fibrosis}, key = {cite}, author = {Uyan, Zeynep Seda and Üstün, Göksenin Ünlügüzel and Haklar, Goncagül and Çakır, Erkan and Oktem, Sedat and Ersu, Refika and Karadağ, Bülent Taner and Karakoç, Fazilet and Dağlı, Elif} }
APA Uyan, Z , Üstün, G , Haklar, G , Çakır, E , Oktem, S , Ersu, R , Karadağ, B , Karakoç, F , Dağlı, E . (2017). Effect of inhaled steroids on clinical and inflammatoryparameters in children with cystic fibrosis . Turkish Journal of Medical Sciences , 47 (5) , 1432-1440 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45689/576370
MLA Uyan, Z , Üstün, G , Haklar, G , Çakır, E , Oktem, S , Ersu, R , Karadağ, B , Karakoç, F , Dağlı, E . "Effect of inhaled steroids on clinical and inflammatoryparameters in children with cystic fibrosis" . Turkish Journal of Medical Sciences 47 (2017 ): 1432-1440 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45689/576370>
Chicago Uyan, Z , Üstün, G , Haklar, G , Çakır, E , Oktem, S , Ersu, R , Karadağ, B , Karakoç, F , Dağlı, E . "Effect of inhaled steroids on clinical and inflammatoryparameters in children with cystic fibrosis". Turkish Journal of Medical Sciences 47 (2017 ): 1432-1440
RIS TY - JOUR T1 - Effect of inhaled steroids on clinical and inflammatoryparameters in children with cystic fibrosis AU - Zeynep Seda Uyan , Göksenin Ünlügüzel Üstün , Goncagül Haklar , Erkan Çakır , Sedat Oktem , Refika Ersu , Bülent Taner Karadağ , Fazilet Karakoç , Elif Dağlı Y1 - 2017 PY - 2017 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1432 EP - 1440 VL - 47 IS - 5 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Effect of inhaled steroids on clinical and inflammatoryparameters in children with cystic fibrosis %A Zeynep Seda Uyan , Göksenin Ünlügüzel Üstün , Goncagül Haklar , Erkan Çakır , Sedat Oktem , Refika Ersu , Bülent Taner Karadağ , Fazilet Karakoç , Elif Dağlı %T Effect of inhaled steroids on clinical and inflammatoryparameters in children with cystic fibrosis %D 2017 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 47 %N 5 %R %U
ISNAD Uyan, Zeynep Seda , Üstün, Göksenin Ünlügüzel , Haklar, Goncagül , Çakır, Erkan , Oktem, Sedat , Ersu, Refika , Karadağ, Bülent Taner , Karakoç, Fazilet , Dağlı, Elif . "Effect of inhaled steroids on clinical and inflammatoryparameters in children with cystic fibrosis". Turkish Journal of Medical Sciences 47 / 5 (Ekim 2017): 1432-1440 .
AMA Uyan Z , Üstün G , Haklar G , Çakır E , Oktem S , Ersu R , Karadağ B , Karakoç F , Dağlı E . Effect of inhaled steroids on clinical and inflammatoryparameters in children with cystic fibrosis. Turkish Journal of Medical Sciences. 2017; 47(5): 1432-1440.
Vancouver Uyan Z , Üstün G , Haklar G , Çakır E , Oktem S , Ersu R , Karadağ B , Karakoç F , Dağlı E . Effect of inhaled steroids on clinical and inflammatoryparameters in children with cystic fibrosis. Turkish Journal of Medical Sciences. 2017; 47(5): 1432-1440.
IEEE Z. Uyan , G. Üstün , G. Haklar , E. Çakır , S. Oktem , R. Ersu , B. Karadağ , F. Karakoç ve E. Dağlı , "Effect of inhaled steroids on clinical and inflammatoryparameters in children with cystic fibrosis", Turkish Journal of Medical Sciences, c. 47, sayı. 5, ss. 1432-1440, Eki. 2017

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