Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients

Öz Background/aim: The aim of our study was to compare Tc-99m MDP bone scan and Ga-68 PSMA PET/CT in terms of detection of bone metastasis in prostate cancer patients. Materials and methods: A total of 28 prostate cancer patients with bone scan and PSMA PET/CT performed within 90 days were retrospectively included in our analysis. All bone lesions were scored as negative (score-0), positive (score-1), or suspicious (score-2) for metastasis by two experienced nuclear medicine physicians. Both patient-based and region-based analyses were made for all osseous lesions. Results: On per-patient analysis; sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were 72.7%, 52.9%, 50%, 75%, and 60.7%, respectively, for bone scan and 90.9%, 100%, 100%, 94.4%, and 96.4%, respectively, for PSMA PET/CT. On per-region analysis; sensitivity, specificity, PPV, NPV, and accuracy were 76.2%, 80.9%, 57.1%, 91.1%, and 79.8%, respectively, for bone scan and 85.7%, 100%, 100%, 95.5%, and 95.4%, respectively, for PSMA PET/CT.Conclusion: Ga-68 PSMA PET/CT has higher sensitivity, specificity, and accuracy compared to bone scan in terms of bone metastasis detection in prostate cancer patients. Therefore, it might be the modality of choice for patients with suspicion for metastatic disease, despite negative bone scan and conventional imaging results.

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Bibtex @ { tbtkmedical577818, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2019}, volume = {49}, pages = {301 - 310}, doi = {}, title = {Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients}, key = {cite}, author = {Beşli, Rabia Lebriz Uslu and Sağer, Muhammet Sait and Akgün, Elife and Asa, Sertaç and Şahin, Onur Erdem and Demirdağ, Çetin and Güner, Ekrem and Razavikhosroshahi, Seyedbaresh and Karayel, Emre and Pehlivanoğlu, Hüseyin and Aygün, Aslan and Uslu, İlhami and Talat, Zübeyr and Sönmezoğlu, Kerim} }
APA Beşli, R , Sağer, M , Akgün, E , Asa, S , Şahin, O , Demirdağ, Ç , Güner, E , Razavikhosroshahi, S , Karayel, E , Pehlivanoğlu, H , Aygün, A , Uslu, İ , Talat, Z , Sönmezoğlu, K . (2019). Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients . Turkish Journal of Medical Sciences , 49 (1) , 301-310 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45750/577818
MLA Beşli, R , Sağer, M , Akgün, E , Asa, S , Şahin, O , Demirdağ, Ç , Güner, E , Razavikhosroshahi, S , Karayel, E , Pehlivanoğlu, H , Aygün, A , Uslu, İ , Talat, Z , Sönmezoğlu, K . "Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients" . Turkish Journal of Medical Sciences 49 (2019 ): 301-310 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45750/577818>
Chicago Beşli, R , Sağer, M , Akgün, E , Asa, S , Şahin, O , Demirdağ, Ç , Güner, E , Razavikhosroshahi, S , Karayel, E , Pehlivanoğlu, H , Aygün, A , Uslu, İ , Talat, Z , Sönmezoğlu, K . "Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients". Turkish Journal of Medical Sciences 49 (2019 ): 301-310
RIS TY - JOUR T1 - Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients AU - Rabia Lebriz Uslu Beşli , Muhammet Sait Sağer , Elife Akgün , Sertaç Asa , Onur Erdem Şahin , Çetin Demirdağ , Ekrem Güner , Seyedbaresh Razavikhosroshahi , Emre Karayel , Hüseyin Pehlivanoğlu , Aslan Aygün , İlhami Uslu , Zübeyr Talat , Kerim Sönmezoğlu Y1 - 2019 PY - 2019 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 301 EP - 310 VL - 49 IS - 1 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients %A Rabia Lebriz Uslu Beşli , Muhammet Sait Sağer , Elife Akgün , Sertaç Asa , Onur Erdem Şahin , Çetin Demirdağ , Ekrem Güner , Seyedbaresh Razavikhosroshahi , Emre Karayel , Hüseyin Pehlivanoğlu , Aslan Aygün , İlhami Uslu , Zübeyr Talat , Kerim Sönmezoğlu %T Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients %D 2019 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 49 %N 1 %R %U
ISNAD Beşli, Rabia Lebriz Uslu , Sağer, Muhammet Sait , Akgün, Elife , Asa, Sertaç , Şahin, Onur Erdem , Demirdağ, Çetin , Güner, Ekrem , Razavikhosroshahi, Seyedbaresh , Karayel, Emre , Pehlivanoğlu, Hüseyin , Aygün, Aslan , Uslu, İlhami , Talat, Zübeyr , Sönmezoğlu, Kerim . "Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients". Turkish Journal of Medical Sciences 49 / 1 (Şubat 2019): 301-310 .
AMA Beşli R , Sağer M , Akgün E , Asa S , Şahin O , Demirdağ Ç , Güner E , Razavikhosroshahi S , Karayel E , Pehlivanoğlu H , Aygün A , Uslu İ , Talat Z , Sönmezoğlu K . Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients. Turkish Journal of Medical Sciences. 2019; 49(1): 301-310.
Vancouver Beşli R , Sağer M , Akgün E , Asa S , Şahin O , Demirdağ Ç , Güner E , Razavikhosroshahi S , Karayel E , Pehlivanoğlu H , Aygün A , Uslu İ , Talat Z , Sönmezoğlu K . Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients. Turkish Journal of Medical Sciences. 2019; 49(1): 301-310.
IEEE R. Beşli , M. Sağer , E. Akgün , S. Asa , O. Şahin , Ç. Demirdağ , E. Güner , S. Razavikhosroshahi , E. Karayel , H. Pehlivanoğlu , A. Aygün , İ. Uslu , Z. Talat ve K. Sönmezoğlu , "Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients", Turkish Journal of Medical Sciences, c. 49, sayı. 1, ss. 301-310, Şub. 2019

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