Kenan ÇADIRCI, Osman Okan OLCAYSU, Derman YİĞİT, Ayşe ÇARLIOĞLU, Şenay DURMAZ ARIKAN

Tip 2 diabetik hastalarda ortalama trombosit hacmi: mikrovasküler komplikasyonlar ile ortalama trombosit hacmi arasında bir ilişki var mı?

Amaç: Diabetik hastaların çoğunda vasküler trombotik ve aterosklerotik komplikasyonlar görülür. Diabetik hastalardatrombosit boyutundaki değişiklikler aterosklerotik komplikasyonlar ile ilişkilidir. Bu çalışmanın amacı, tip 2 diabetik hastalardaortalama trombosit hacmi (Mean Platelet Volume, MPV) ile mikrovasküler komplikasyonlar arasındaki ilişkiyi saptamaktır.Gereç ve Yöntemler: Bu çalışmaya 115 tip 2 DM tanılı hasta (ortalama yaş 50.4±9.9 yıl ve BMI 31.0±5.3 kg/m²) ve tamamensağlıklı ve sistemik hastalığı bulunmayan 67 kişide (ortalama yaş 48.8±12.0 yıl ve BMI 30.3±7.3 kg/m²) kontrol grubuolarak dahil edildi. Diabetik grupta kronik diabetik mikrovasküler komplikasyonlar araştırıldı. Nörolojik değerlendirme,oküler fundus muayenesi ve EMG (Elektromyografi) yapıldı. Diabetik hastalarımız öncelikle en az bir mikrovaskülerkomplikasyonu olan ve olmayan şeklinde ikiye ayrıldı. Daha sonra mikrovasküler komplikasyonu olan hastalar nefropati,nöropati ve retinopatiye göre alt gruplara ayrıldı. Tüm alt gruplarda MPV düzeyi tekrar analiz edildi.Bulgular: En az bir mikrovasküler komplikasyonu olan diabetik hasta grubumuzda 79 hasta mevcutdu. Bu grup da, 44 (%34.7)hastada nöropati, 33 (%26.0) hastada diabetik nefropati ve 13 (%10.2) hastada ise diabetik retinopati tespit edildi. Mikrovaskülerkomplikasyonu olmayan diabetik hasta grubunda ise 36 kişi mevcutdu. Bu grup ise diabetik kontrol grubu olarak kabul edildi.Diabetik mikrovasküler grupta MPV düzeyleri sağlıklı kontrol grubundan anlamlı olarak yüksekti (sırasıyla 8.6±0.8fL ve7.9±0.8fL, p

Mean platelet volume in type 2 diabetic patient: is there a relationship between mean platelet volume and diabetic microvascular complications?

Aim: Most diabetic patients suffer from vascular thrombotic and atherosclerotic complications. Alteration in platelet size are associated with atherosclerotic complications in patients with diabetes. The aim of present study is to determine the relationship between mean platelet volume (MPV) and microvascular diabetic complications in type 2 diabetic patients. Material and Methods: 115 type 2 diabetic patients [mean age 50.4±9.9 year and body mass index (BMI) 31.0±5.3 kg/ m2 ], and 67 healthy control subjects without any systemic disease (mean age 48.8±12.0 year and BMI 30.3±7.3 kg/m2 ) were included in this study. Chronic diabetic microvascular complications in diabetic group were researched. Neurological evaluation, ocular fundus examination and EMG (electromyography) were performed. Our diabetic patients were initially divided into two groups with and without at least one microvascular complication. Subsequently, patients with microvascular complications were divided into subgroups according to nephropathy, neuropathy and retinopathy. MPV levels were re-analyzed in all subgroups. Results: There were 79 patients in our diabetic patient group with at least one microvascular complication. In this group, 44 (34.7%) patient neuropathy, 33 (26.0%) patients diabetic nephropathy and 13 (10.2%) patients diabetic retinopathy were detected. There were 36 patients in the diabetic group without microvascular complications. This group was accepted as a diabetic control group. We determined that mean MPV levels in diabetic microvascular group was significantly different from control group (8.6±0.8 fL and 7.9±0.8 fL, p

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