Aynur ARSLAN, Nazlıgül KARAÜZÜM YALÇIN, Emine KARTAL BAYKAN, Mustafa UTLU, Havva Tuğba KİPER YILMAZ, Alperen Akansel ÇAĞLAR, Emre DEVE, Emrah DOĞAN, Ayşe ÇARLIOĞLU

Akromegali hastalarında yağlı karaciğer

Amaç: Akromegali hastalarında, diabetes mellitus, insülin direnci ve hipertrigliseridemi gibi metabolik durumlara sıklıkla rastlanır. Bizim amacımız, akromegali hastalarında, non alkolik yağlı karaciğer (NAFLD) gelişmesinde etkili olan faktörleri saptamaktır.Gereç ve Yöntemler: 60 (33 kadın, 27 erkek) akromegali hastası ve 52 sağlıklı kişiden (27 kadın ve 25 erkek) oluşan kontrol grubu retrospektif olarak incelendi. Hastaların ve kontrol grubunun ortalama yaşı sırasıyla 44.11 ±13.83 ve 39.12±14.99’du. Beden kitle indeksi (BKİ), karaciğer ultrasonografisi ve laboratuvar sonuçları dosyalarındaki kayıtlardan alındı. İstatistik analizlerde IBM SPSS Versiyon 22.0 istatistiksel paket programı (IBM Corporation, USA) kullanıldı.Bulgular: Akromegali hastalarında açlık kan şekeri, trigliserid, insülin benzeri büyüme faktörü, büyüme hormonu (GH) ve CRP seviyeleri kontrol grubuna göre anlamlı derecede yüksek, HDL düzeyleri anlamlı derecede düşük bulundu. Grupların BKİ ve NAFLD oranları benzerdi. Akromegali hastalarında BKİ ve GH’un NAFLD gelişmesinde en önemli iki faktör olduğu sonucuna ulaştık. NAFLD, hastanın BKİ, kilo ve yaşı ile anlamlı derecede pozitif, GH düzeyi ile anlamlı derecede negatif korelasyon gösterdi. Sonuç: Akromegali hastalarında, NAFLD gelişmesini etkileyen faktörler BKİ ve GH’dur.

Anahtar Kelimeler:

acromegaly, non-alcoholic fatty liver disease, body-mass index

Fatty liver in patients with acromegaly

Aim: Patients with acromegaly are at risk of metabolic diseases, such as diabetes mellitus, insulin resistance and hypertriglyceridemia. We aimed to investigate what is effective in the development of non-alcoholic fatty liver disease (NAFLD) in patients with acromegaly.Materials and Methods: 60 (33 female, 27 male) patients with acromegaly, and a healthy control group of 52 persons (27 female and 25 male) were retrospectively studied. Mean age of the patients and the control group were 44.11 ±13.83 and 39.12±14.99 respectively. Body mass index (BMI), liver ultrasound and laboratory findings were taken from the records in the files. Statistical analyzes were performed using SPSS statistical software package version 22 (IBM Corporation, USA).Results: Fasting blood sugar, triglyceride, insulin like growth factor, growth hormone(GH) and CRP levels were significantly higher, HDL levels were significantly lower in acromegaly group. BMI and NAFLD were similar between groups. We found that, BMI and GH are the most important two factors in the presence of NAFLD in patients with acromegaly. NAFLD correlates significantly positively with the patient's BMI, weight and age; significantly negatively with the GH levels. Conclusion: In people with acromegaly, BMI and GH levels are the things that affect development of NAFLD.

Keywords:

acromegaly, non-alcohololic fatty liver disease, body mass index,

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