Meltem KARŞIYAKA HENDEK, Ebru OLGUN ERDEMİR, Üçler KISA

Periodontal hastalıkta ileri oksidasyon protein ürünleri ve monosit kemoatraktan protein-1

Amaç: Çalışmanın amacı periodontal hastalıklı ve sağlıklı bireylerde dişeti oluğu sıvısı (DOS) ileri oksidasyon protein ürünleri (AOPP) ve monosit kemoatraktan protein-1 (MCP)-1seviyelerini belirlemekti.Gereç ve Yöntem: 25 kronik periodontitisli (KP), 25 gingivitisli (G) ve 25 periodontal sağlıklı (S) toplam da 75 sigara içmeyen birey çalışmaya dahil edildi. Sondalanabilir cep derinliği (SCD), klinik ataşman seviyesi (KAS), plak indeksi (Pİ) ve gingival indeks (Gİ) kaydedildi. Her bireyde 4 alandan DOS örnekleri toplandı ve DOS AOPP ve MCP-1 seviyeleri enzim bağlı immunosorbent analizi ile belirlendi. Bulgular: DOS AOPP ve MCP-1 seviyeleri en düşük S grupta; ardından G grubunda ve en yüksek KP grubunda idi. Bu farklılıklar G ve S grupları ile KP ve diğer gruplar arasında istatistiksel olarak anlamlı farklıydı (p <.05). DOS AOPP ve MCP-1 seviyeleri arasında pozitif istatistiksel korelasyon bulundu. Sonuç: Periodontal inflamasyon sırasında DOS AOPP ve MCP-1 seviyeleri önemli bir rol oynayabilir ve artmış DOS AOPP ve MCP-1 seviyeleri, periodontal hastalıklar için potansiyel bir biyolojik belirteç olarak önerilebilir.

Anahtar Kelimeler:

İleri oksidasyon protein ürünleri, dişeti oluğu sıvısı, monosit kemoatraktan protein, oksidatif stres, periodontitis

Advanced oxidation protein products and monocyte chemoattractant protein-1 in periodontal disease

Aim: The aim of the study was to determine gingival crevicular fluid (GCF) levels of advanced oxidation protein product (AOPP) and monocyte chemoattractant protein (MCP)-1 in subjects with periodontal disease and health. Material and Method: A total of 75 non-smokers, including 25 participants with chronic periodontitis (CP), 25 participants with gingivitis (G) and 25 participants with periodontally healthy (H) were included into the present study. The probing depth (PD), clinical attachment level (CAL), plaque index (PI) and gingival index (GI) were recorded. The GCF samples from 4 sites in each individual were collected and GCF AOPP and MCP-1 levels were determined by enzyme-linked immunosorbent assay method.Results: GCF AOPP and MCP-1 levels were the lowest in the H group; followed by the G group and the highest in the CP group. These differences were statistically significant between G and H groups and between the CP and the other groups (p <.05). A statistically positive correlation was detected between GCF AOPP and MCP-1 levels. Conclusion: GCF AOPP and MCP-1 levels might play a considerable role during periodontal inflammation and an elevated GCF AOPP and MCP-1 levels are suggested as a potential biomarker for periodontal diseases.

Keywords:

Advanced oxidation protein products, gingival crevicular fluid, monocyte chemoattractant protein, oxidative stress, periodontitis,

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