Öztekin ALGÜL, Berrin ÖZÇELİK

5629

Synthesis, Characterization and Genotoxicity of Platinum(II)Complexes With Subtituted Benzimidazole Ligands

Five Pt(II) complexes with the ligands 2-ethyl-/ or-benzyl-/ or-phenoxymethyl- and 1-methyl-2-hydroxymethyl- and 1-methyl-2-phenyl- benzimidazoles were synthesized and characterized by elemental analysis, and IR and 1H-NMR spectra and evaluated for their in vitro genotoxic activities by Rec-Assay test. Based on the data obtained in this study, the Pt(II) complexes tested might be taken into consideration as promising antitumor compounds.

Anahtar Kelimeler:

Benzimidazol, Platinum(II) complexes, In vitro genotoxic activity, Rec-Assay test

Synthesis, Characterization and Genotoxicity of Platinum(II)Complexes With Subtituted Benzimidazole Ligands

Five Pt(II) complexes with the ligands 2-ethyl-/ or-benzyl-/ or-phenoxymethyl- and 1-methyl-2-hydroxymethyl- and 1-methyl-2-phenyl- benzimidazoles were synthesized and characterized by elemental analysis, and IR and 1H-NMR spectra and evaluated for their in vitro genotoxic activities by Rec-Assay test. Based on the data obtained in this study, the Pt(II) complexes tested might be taken into consideration as promising antitumor compounds.

Keywords:

Benzimidazol, Platinum(II) complexes, In vitro genotoxic activity, Rec-Assay test,

Turkish Journal of Chemistry-Cover

ISSN: 1300-0527
Yayın Aralığı: Yılda 6 Sayı
Yayıncı: TÜBİTAK

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