Synthesis, characterization, and antibacterial effect of 4-methoxy-2-(5-H/Me/Cl/NO2-1H-benzimidazol-2-yl)- phenols and some transition metal complexes

4-Methoxy-2-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl)-phenol(HLX; X=1-4) ligands and HL1 complexes with Fe(NO3)3, Cu(NO3)2, AgNO3, and Zn(NO3)2 were synthesized and characterized. The structures of the compounds were confirmed on the basis of elemental analysis, molar conductivity, magnetic moment, FT-IR, UV-visible, and 1H- and 13C-NMR. Antibacterial activity of the free ligands, their hydrochloride salts, and the complexes was evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimum inhibitory concentration (MIC) dilution method, against 9 bacteria, and the results were compared with penicillin-G and oxytetracycline. It was observed that HL1, [Ag(HL1)](NO3), and [Cu(L1)2](H2O)2 are effective on S. epidermidis, S. aureus, and B. subtilis (gram+) organisms compared with the other compounds. All compounds except HL4 and [Zn(L1)(H2O)2]NO3 showed antibacterial activity on S. aureus.

Synthesis, characterization, and antibacterial effect of 4-methoxy-2-(5-H/Me/Cl/NO2-1H-benzimidazol-2-yl)- phenols and some transition metal complexes

4-Methoxy-2-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl)-phenol(HLX; X=1-4) ligands and HL1 complexes with Fe(NO3)3, Cu(NO3)2, AgNO3, and Zn(NO3)2 were synthesized and characterized. The structures of the compounds were confirmed on the basis of elemental analysis, molar conductivity, magnetic moment, FT-IR, UV-visible, and 1H- and 13C-NMR. Antibacterial activity of the free ligands, their hydrochloride salts, and the complexes was evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimum inhibitory concentration (MIC) dilution method, against 9 bacteria, and the results were compared with penicillin-G and oxytetracycline. It was observed that HL1, [Ag(HL1)](NO3), and [Cu(L1)2](H2O)2 are effective on S. epidermidis, S. aureus, and B. subtilis (gram+) organisms compared with the other compounds. All compounds except HL4 and [Zn(L1)(H2O)2]NO3 showed antibacterial activity on S. aureus.

___

  • OH2 OH2 O + O H N H H3CO + NO Figure 3. The proposal structures for the complexes under study.
Turkish Journal of Chemistry-Cover
  • ISSN: 1300-0527
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

The synthesis, characterization and energy transfer efficiency of a dithienylpyrrole and BODIPY Based Donor-Acceptor System

Taner ATALAR, Atilla Cihaner And Fatih ALGI

A density functional theory study of oxidation of benzene to phenol by N2O on Fe- and Co-ZSM-5 clusters

Mehmet Ferdi FELLAH, Işık ÖNAL

Characterization and electrochemical study of nano-composition based methylene blue-and riboflavin-nafion on the surface of a gold electrode

Aisha JAVED, Saeed Rezaeı ZARCHI, Hossein MIRJALILI, Hossain Barı ABARGHOUEI, Seyed Alı HASHEMIZADEH

Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety

Abdel-Galil El-Sayed AMR, Naglaa Abdel-Samei ABDEL-HAFEZ, Salwa Fahem MOHAMED, Mohamed Mostafa ABDALLA

Methanol dehydration reaction to produce clean diesel alternative dimethylether over mesoporous aluminosilicate-based catalysts

Dilek VARIŞLI, Kenan Cem TOKAY, Ay&#;egül ÇİFTÇİ

Improved photostability of PVC films in the presence of 2-thioacetic acid-5-phenyl-1,3,4-oxadiazole complexes

Emad A. YOUSIF, Salah M. ALIWI, Ameer A. AMEER

A density functional theory study of oxidation of benzene to phenol by $N_2O$ on Fe-and Co-ZSM-5 clusters

Mehmet Ferdi FELLAH, Işık ÖNAL

Synthesis and Antimicrobial Activity of Dinaphtho[2,1-b]furan-2-yl-methanone and Their Oxime Derivatives

Cumhur KIRILMIŞ, Murat KOCA, Süleyman SERVİ And

Investigation of the fuel properties of biodiesel produced over an alumina-based solid catalyst

Nezahat BOZ, Miray KARA, Oylum SUNAL

Characterization and Electrochemical Study of Nano-Composition Based Methylene Blue- and Riboflavin-Nafion on the Surface of Gold Electrode

Saeed REZAEI-ZARCHI, Aisha JAVED, Hossein MIRJALILI, Hossain BARI ABARGHOUEI, Seyed ALI HASHEMIZADEH