Leyla YURTTAŞ, Yusuf ÖZKAY, Fatih DEMİRCİ, Gamze GÖGER, Şafak Ulusoylar YILDIRIM, Usama ABU MOHSEN, Ömer ÖZTÜRK, Zafer Asım KAPLANCIKLI

Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains

Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a--j) were confirmed by spectral data (IR, 1H NMR, 13C NMR, and MS) and elemental analysis. The anticandidal activity of the compounds was determined (6a--j) using the microbroth dilution method and their cytotoxicity was evaluated according to the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against normal cells. Contrary to expectations, weak antifungal activity was observed with IC50 values ranging between 30 and 403 m g/mL.

Anahtar Kelimeler:

Thiazole, dithiocarbamate, anticandidal activity, cytotoxicity

Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains

Keywords:

Thiazole, dithiocarbamate, anticandidal activity, cytotoxicity,

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