Hüseyin İSTANBULLU, Hakan KARADENİZ, Erçin ERCİYAS, Kadriye Arzum Erdem GÜRSAN

Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes

Öz Four different Mannich base derivatives containing an aromatic/heteroaromatic propanone structure (C1 (3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride); C2 (3-morpholino-1-(pyridin-3-yl)propan-1-one hydrochloride); C3 (3-(dimethylamino)-1-(1H-indol-3-yl)propan-1-one hydrochloride), C4 (3-(piperidin-1-yl)-1-(pyren-1-yl)propan-1-one hydrochloride)) were earlier synthesized and characterized with $^{1}$H NMR, $^{13}$C NMR, MS, and elemental analysis. The interaction of these compounds with fish sperm double stranded DNA (fs-dsDNA) was investigated by using differential pulse voltammetry (DPV) in connection with a disposable pencil graphite electrode (PGE). After the interaction procedure, there was a meaningful decrease in the oxidation signal of the electroactive DNA base guanine due to possible intercalation and/or alkylation mechanism between these Mannich base derivatives and DNA. The features of this electrochemical assay were discussed in comparison to previous reports related to DNA targeted agents/drug candidates in the literature.

Anahtar Kelimeler:

Electrochemical DNA biosensor, Mannich base, pencil graphite electrode, differential pulse voltammetry

Tam Metin

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Bibtex	`@ { tbtkchem387935, journal = {Turkish Journal of Chemistry}, issn = {1300-0527}, eissn = {1303-6130}, address = {}, publisher = {TÜBİTAK}, year = {2017}, volume = {41}, pages = {40 - 47}, doi = {}, title = {Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes}, key = {cite}, author = {İstanbullu, Hüseyin and Karadeniz, Hakan and Erciyas, Erçin and Gürsan, Kadriye Arzum Erdem} }`
APA	İstanbullu, H , Karadeniz, H , Erciyas, E , Gürsan, K . (2017). Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes . Turkish Journal of Chemistry , 41 (1) , 40-47 .
MLA	İstanbullu, H , Karadeniz, H , Erciyas, E , Gürsan, K . "Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes" . Turkish Journal of Chemistry 41 (2017 ): 40-47 <
Chicago	İstanbullu, H , Karadeniz, H , Erciyas, E , Gürsan, K . "Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes". Turkish Journal of Chemistry 41 (2017 ): 40-47
RIS	TY - JOUR T1 - Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes AU - Hüseyin İstanbullu , Hakan Karadeniz , Erçin Erciyas , Kadriye Arzum Erdem Gürsan Y1 - 2017 PY - 2017 N1 - DO - T2 - Turkish Journal of Chemistry JF - Journal JO - JOR SP - 40 EP - 47 VL - 41 IS - 1 SN - 1300-0527-1303-6130 M3 - UR - Y2 - 2021 ER -
EndNote	%0 Turkish Journal of Chemistry Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes %A Hüseyin İstanbullu , Hakan Karadeniz , Erçin Erciyas , Kadriye Arzum Erdem Gürsan %T Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes %D 2017 %J Turkish Journal of Chemistry %P 1300-0527-1303-6130 %V 41 %N 1 %R %U
ISNAD	İstanbullu, Hüseyin , Karadeniz, Hakan , Erciyas, Erçin , Gürsan, Kadriye Arzum Erdem . "Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes". Turkish Journal of Chemistry 41 / 1 (Şubat 2017): 40-47 .
AMA	İstanbullu H , Karadeniz H , Erciyas E , Gürsan K . Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes. Turk J Chem. 2017; 41(1): 40-47.
Vancouver	İstanbullu H , Karadeniz H , Erciyas E , Gürsan K . Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes. Turkish Journal of Chemistry. 2017; 41(1): 40-47.
IEEE	H. İstanbullu , H. Karadeniz , E. Erciyas ve K. Gürsan , "Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes", Turkish Journal of Chemistry, c. 41, sayı. 1, ss. 40-47, Şub. 2017