Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes

Öz Four different Mannich base derivatives containing an aromatic/heteroaromatic propanone structure (C1 (3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride); C2 (3-morpholino-1-(pyridin-3-yl)propan-1-one hydrochloride); C3 (3-(dimethylamino)-1-(1H-indol-3-yl)propan-1-one hydrochloride), C4 (3-(piperidin-1-yl)-1-(pyren-1-yl)propan-1-one hydrochloride)) were earlier synthesized and characterized with $^{1}$H NMR, $^{13}$C NMR, MS, and elemental analysis. The interaction of these compounds with fish sperm double stranded DNA (fs-dsDNA) was investigated by using differential pulse voltammetry (DPV) in connection with a disposable pencil graphite electrode (PGE). After the interaction procedure, there was a meaningful decrease in the oxidation signal of the electroactive DNA base guanine due to possible intercalation and/or alkylation mechanism between these Mannich base derivatives and DNA. The features of this electrochemical assay were discussed in comparison to previous reports related to DNA targeted agents/drug candidates in the literature.

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Bibtex @ { tbtkchem387935, journal = {Turkish Journal of Chemistry}, issn = {1300-0527}, eissn = {1303-6130}, address = {}, publisher = {TÜBİTAK}, year = {2017}, volume = {41}, pages = {40 - 47}, doi = {}, title = {Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes}, key = {cite}, author = {İstanbullu, Hüseyin and Karadeniz, Hakan and Erciyas, Erçin and Gürsan, Kadriye Arzum Erdem} }
APA İstanbullu, H , Karadeniz, H , Erciyas, E , Gürsan, K . (2017). Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes . Turkish Journal of Chemistry , 41 (1) , 40-47 .
MLA İstanbullu, H , Karadeniz, H , Erciyas, E , Gürsan, K . "Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes" . Turkish Journal of Chemistry 41 (2017 ): 40-47 <
Chicago İstanbullu, H , Karadeniz, H , Erciyas, E , Gürsan, K . "Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes". Turkish Journal of Chemistry 41 (2017 ): 40-47
RIS TY - JOUR T1 - Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes AU - Hüseyin İstanbullu , Hakan Karadeniz , Erçin Erciyas , Kadriye Arzum Erdem Gürsan Y1 - 2017 PY - 2017 N1 - DO - T2 - Turkish Journal of Chemistry JF - Journal JO - JOR SP - 40 EP - 47 VL - 41 IS - 1 SN - 1300-0527-1303-6130 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Chemistry Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes %A Hüseyin İstanbullu , Hakan Karadeniz , Erçin Erciyas , Kadriye Arzum Erdem Gürsan %T Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes %D 2017 %J Turkish Journal of Chemistry %P 1300-0527-1303-6130 %V 41 %N 1 %R %U
ISNAD İstanbullu, Hüseyin , Karadeniz, Hakan , Erciyas, Erçin , Gürsan, Kadriye Arzum Erdem . "Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes". Turkish Journal of Chemistry 41 / 1 (Şubat 2017): 40-47 .
AMA İstanbullu H , Karadeniz H , Erciyas E , Gürsan K . Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes. Turk J Chem. 2017; 41(1): 40-47.
Vancouver İstanbullu H , Karadeniz H , Erciyas E , Gürsan K . Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes. Turkish Journal of Chemistry. 2017; 41(1): 40-47.
IEEE H. İstanbullu , H. Karadeniz , E. Erciyas ve K. Gürsan , "Electrochemical detection of DNA interaction with Mannich base derivatives by disposable graphite electrodes", Turkish Journal of Chemistry, c. 41, sayı. 1, ss. 40-47, Şub. 2017
Turkish Journal of Chemistry
  • ISSN: 1300-0527
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK

37.5b15.9b

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