Design, synthesis, cytotoxic activity, and apoptosis inducing effects of 4-and N-substituted benzoyltaurinamide derivatives

Öz In this study, a group of 4-substituted benzoyltaurinamide derivatives were designed, synthesized, and investigated for their anticancer activity against three cancer cell lines and one nontumorigenic cell line by MTT assay. Among the final compounds, methoxyphenyl derivatives 14, 15, 16 were found to be effective against all the tested cancerous cell lines with promising selectivity. The most active compounds were further evaluated to determine the molecular mechanism of their anticancer activity by using western blot assay and the Annexin V-FITC/PI test. Compound 14 (in SH-SY5Y and MDA-MB-231 cell lines) and 15 (in SH-SY5Y cell line) were found to induce intrinsic apoptotic pathway by upregulating BAX, caspase-3, and caspase-9, while downregulating Bcl-2 and Bcl-xL expression levels. According to mechanistic studies, compounds displayed their anticancer activity via three different mechanisms: a. caspase-dependent, b. caspase-independent, and c. caspase-dependent pathway that excluded caspase-9 activation. As a result, this study provides interesting data which can be used to design new taurine-based anticancer derivatives.

Kaynakça

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Kaynak Göster

Bibtex @araştırma makalesi { tbtkchem945135, journal = {Turkish Journal of Chemistry}, issn = {1300-0527}, eissn = {1303-6130}, address = {}, publisher = {TÜBİTAK}, year = {2020}, volume = {44}, pages = {1674 - 1693}, doi = {}, title = {Design, synthesis, cytotoxic activity, and apoptosis inducing effects of 4-and N-substituted benzoyltaurinamide derivatives}, key = {cite}, author = {Akgul, Ozlem and Erdogan, Mumin Alper and Birim, Dervis and Kayabasi, Cagla and Gunduz, Cumhur and Armagan, Guliz} }
APA Akgul, O , Erdogan, M , Birim, D , Kayabasi, C , Gunduz, C , Armagan, G . (2020). Design, synthesis, cytotoxic activity, and apoptosis inducing effects of 4-and N-substituted benzoyltaurinamide derivatives . Turkish Journal of Chemistry , 44 (6) , 1674-1693 .
MLA Akgul, O , Erdogan, M , Birim, D , Kayabasi, C , Gunduz, C , Armagan, G . "Design, synthesis, cytotoxic activity, and apoptosis inducing effects of 4-and N-substituted benzoyltaurinamide derivatives" . Turkish Journal of Chemistry 44 (2020 ): 1674-1693 <
Chicago Akgul, O , Erdogan, M , Birim, D , Kayabasi, C , Gunduz, C , Armagan, G . "Design, synthesis, cytotoxic activity, and apoptosis inducing effects of 4-and N-substituted benzoyltaurinamide derivatives". Turkish Journal of Chemistry 44 (2020 ): 1674-1693
RIS TY - JOUR T1 - Design, synthesis, cytotoxic activity, and apoptosis inducing effects of 4-and N-substituted benzoyltaurinamide derivatives AU - Ozlem Akgul , Mumin Alper Erdogan , Dervis Birim , Cagla Kayabasi , Cumhur Gunduz , Guliz Armagan Y1 - 2020 PY - 2020 N1 - DO - T2 - Turkish Journal of Chemistry JF - Journal JO - JOR SP - 1674 EP - 1693 VL - 44 IS - 6 SN - 1300-0527-1303-6130 M3 - UR - Y2 - 2020 ER -
EndNote %0 Turkish Journal of Chemistry Design, synthesis, cytotoxic activity, and apoptosis inducing effects of 4-and N-substituted benzoyltaurinamide derivatives %A Ozlem Akgul , Mumin Alper Erdogan , Dervis Birim , Cagla Kayabasi , Cumhur Gunduz , Guliz Armagan %T Design, synthesis, cytotoxic activity, and apoptosis inducing effects of 4-and N-substituted benzoyltaurinamide derivatives %D 2020 %J Turkish Journal of Chemistry %P 1300-0527-1303-6130 %V 44 %N 6 %R %U
ISNAD Akgul, Ozlem , Erdogan, Mumin Alper , Birim, Dervis , Kayabasi, Cagla , Gunduz, Cumhur , Armagan, Guliz . "Design, synthesis, cytotoxic activity, and apoptosis inducing effects of 4-and N-substituted benzoyltaurinamide derivatives". Turkish Journal of Chemistry 44 / 6 (Aralık 2020): 1674-1693 .
AMA Akgul O , Erdogan M , Birim D , Kayabasi C , Gunduz C , Armagan G . Design, synthesis, cytotoxic activity, and apoptosis inducing effects of 4-and N-substituted benzoyltaurinamide derivatives. Turk J Chem. 2020; 44(6): 1674-1693.
Vancouver Akgul O , Erdogan M , Birim D , Kayabasi C , Gunduz C , Armagan G . Design, synthesis, cytotoxic activity, and apoptosis inducing effects of 4-and N-substituted benzoyltaurinamide derivatives. Turkish Journal of Chemistry. 2020; 44(6): 1674-1693.
IEEE O. Akgul , M. Erdogan , D. Birim , C. Kayabasi , C. Gunduz ve G. Armagan , "Design, synthesis, cytotoxic activity, and apoptosis inducing effects of 4-and N-substituted benzoyltaurinamide derivatives", Turkish Journal of Chemistry, c. 44, sayı. 6, ss. 1674-1693, Ara. 2020
  • ISSN: 1300-0527
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK

18.8b 10.9b

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