Bis benzothiophene Schiff bases: synthesis and in silico-guided biological activity studies

Öz Since benzo [b ] thiophene scaffold is one of the privileged structures in drug discovery as this core exhibitsactivities for different biological problems, in this study bis (benzo[b ]thiophene-2-yl) alkyl methanimine derivatives (1-9) were synthesized by reacting benzo[b ]thiophene-2-carbaldehyde with diamines. All newly compounds were characterized by IR, 1 H NMR and 13 C NMR spectroscopic methods. Synthesized compounds were investigated using binary QSARbased models on therapeutic activity prediction of synthesized compounds and they showed high predicted activities in following diseases: bacterial, angina, allergy, depression and obesity. Thus, they were then tested for their antimicrobial and antileishmanial activities as a result of this theoretical study. Compound 1(N, N’- (propane-1,3-diyl) bis (1-(benzo [b ] thiophene-2-yl)) methanimine) was found the most active compound in both diseases. Thus, its molecular docking studies were also carried out.

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Kaynak Göster

Bibtex @araştırma makalesi { tbtkchem945497, journal = {Turkish Journal of Chemistry}, issn = {1300-0527}, eissn = {1303-6130}, address = {}, publisher = {TÜBİTAK}, year = {2020}, volume = {44}, pages = {1164 - 1176}, doi = {}, title = {Bis benzothiophene Schiff bases: synthesis and in silico-guided biological activity studies}, key = {cite}, author = {Unver, Yasemin and Unluer, Dilek and Direkel, Sahin and Durdagi, Serdar} }
APA Unver, Y , Unluer, D , Direkel, S , Durdagi, S . (2020). Bis benzothiophene Schiff bases: synthesis and in silico-guided biological activity studies . Turkish Journal of Chemistry , 44 (4) , 1164-1176 .
MLA Unver, Y , Unluer, D , Direkel, S , Durdagi, S . "Bis benzothiophene Schiff bases: synthesis and in silico-guided biological activity studies" . Turkish Journal of Chemistry 44 (2020 ): 1164-1176 <
Chicago Unver, Y , Unluer, D , Direkel, S , Durdagi, S . "Bis benzothiophene Schiff bases: synthesis and in silico-guided biological activity studies". Turkish Journal of Chemistry 44 (2020 ): 1164-1176
RIS TY - JOUR T1 - Bis benzothiophene Schiff bases: synthesis and in silico-guided biological activity studies AU - Yasemin Unver , Dilek Unluer , Sahin Direkel , Serdar Durdagi Y1 - 2020 PY - 2020 N1 - DO - T2 - Turkish Journal of Chemistry JF - Journal JO - JOR SP - 1164 EP - 1176 VL - 44 IS - 4 SN - 1300-0527-1303-6130 M3 - UR - Y2 - 2020 ER -
EndNote %0 Turkish Journal of Chemistry Bis benzothiophene Schiff bases: synthesis and in silico-guided biological activity studies %A Yasemin Unver , Dilek Unluer , Sahin Direkel , Serdar Durdagi %T Bis benzothiophene Schiff bases: synthesis and in silico-guided biological activity studies %D 2020 %J Turkish Journal of Chemistry %P 1300-0527-1303-6130 %V 44 %N 4 %R %U
ISNAD Unver, Yasemin , Unluer, Dilek , Direkel, Sahin , Durdagi, Serdar . "Bis benzothiophene Schiff bases: synthesis and in silico-guided biological activity studies". Turkish Journal of Chemistry 44 / 4 (Ağustos 2020): 1164-1176 .
AMA Unver Y , Unluer D , Direkel S , Durdagi S . Bis benzothiophene Schiff bases: synthesis and in silico-guided biological activity studies. Turk J Chem. 2020; 44(4): 1164-1176.
Vancouver Unver Y , Unluer D , Direkel S , Durdagi S . Bis benzothiophene Schiff bases: synthesis and in silico-guided biological activity studies. Turkish Journal of Chemistry. 2020; 44(4): 1164-1176.
IEEE Y. Unver , D. Unluer , S. Direkel ve S. Durdagi , "Bis benzothiophene Schiff bases: synthesis and in silico-guided biological activity studies", Turkish Journal of Chemistry, c. 44, sayı. 4, ss. 1164-1176, Ağu. 2020
  • ISSN: 1300-0527
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK

11.9b 6.8b

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