Vitaliy SVIRIPA, Michael D. CONROY, Wen ZHANG

Biotinylated N,N'-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)

Biotinylated analogs of drug candidates provide useful tools for studying the drug--target protein interactions. Polyhalogenated N,N'diarylureas are potent activators of adenosine monophosphate-activated kinase (AMPK) and potentially promising agents for the treatment of cancer. Various biotinylated versions of these N,N'-diarylureas were synthesized and evaluated in AMPK-activation studies.

Anahtar Kelimeler:

Adenosine monophosphate-activated kinase, biotinylated N, N'-diarylureas

Biotinylated N,N'-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)

Keywords:

Adenosine monophosphate-activated kinase, biotinylated N, N'-diarylureas,

PDF

___

Hardie, D. G.; Ross, F. A.; Hawley, S. A. Nat. Rev. Mol. Cell Biol. 2012, 13, 251–262.
Steinberg, G. R.; Kemp, B. E Physiol. Rev. 2009, 89, 1025–1078.
Mihaylova, M. M.; Shaw, R. J. Nat. Cell Biol. 2011, 13, 1016–1023.
Yu, L.-F.; Qiu, B.-Y.; Nan, F.-J.; Li, J. Curr. Top. Med. Chem. 2010, 10, 397–410.
Luo, Z.; Zang, M.; Guo, W. Future Oncol. 2010, 6, 457–470.
Terstappen, G. C.; Schl¨ upen, C.; Raggiaschi, R.; Giovanni Gaviraghi, G. Nat. Rev. Drug Dis. 2007, 6, 891–903. Hermanson, G. T. Bioconjugate Techniques, 2nd ed.; Academic Press: San Diego: 2008.
Sviripa, V.; Zhang, W.; Conroy, M. D.; Schmidt, E. S.; Liu, A. X.; Truong, J.; Liu, C.; Watt, D. S. Bioorg. Med. Chem. Lett. 2013, 23, 1600–1603.