Lıa ZAHARANI, Nader Ghaffarı KHALIGH, Zohreh SHAHNAVAZ, Mohd Rafıe JOHAN

Arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the preparation of aryl iodide

In the current protocol, the arene diazonium saccharin derivatives were initially produced from various substituted aromatic amines; subsequently, these intermediates were treated with a greener organic iodide for the preparation of the aryl iodide. We tried to choose low-cost, commercially available, biodegradable, recoverable, ecofriendly, and safe reagents and solvents. The arene diazonium saccharin intermediates could be stored in the liquid phase into a refrigerator for a long time with no significant loss activity. The outstanding merits of the current protocol a included the partial recovering of saccharin and tetraethylammonium salt, b reduce the use of solvents and the reaction steps due to eliminating separation and purification of intermediates, c good yield of the sterically hindered substrates, and d avoid the generation of heavy metal or corrosive waste.

Keywords:

Aromatic iodide, one-pot diazotization-iodination, saccharin, waste prevention,

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