Aylin PIHTILI, Konul MAMMADOVA, Esen KIYAN

STABİL KOAH OLGULARINDA PLAZMA LAKTAT DÜZEYİ

Morbidite ve mortalitesi yüksek olan KOAH’da, prognostik belirteçlerin saptanması önemlidir. Plazma laktat düzeyi, doku oksijen ihtiyacını gösteren ve kolayulaşılabilen bir tetkiktir. Çalışmamızın amacı; stabil KOAH olgularında plazma laktat düzeyi ile GOLD KOAH kategorisi, FEV1, ataklar ve hipoksemi arasındaki ilişkiyi incelemektir.Göğüs Hastalıkları Polikliniği’ne başvuran stabil dönemdeki KOAH olguları retrospektif olarak değerlendirildi. Demografik özellikler, arter kan gazı analizleri,yıllık atak sayıları, GOLD KOAH kategorisine göre; A,B,C,D sınıfları, spirometrik parametreler, evde uzun süreli oksijen tedavisi (USOT) ve non-invaziv mekanikventilasyon (NİMV) kullanıp kullanmadıkları kaydedildi.Toplam 103 stabil KOAH olgusu (E/K: 90/13, ortalama yaş: 66.8±8.0/yıl) çalışmaya dahil edildi. Olguların FEV1:%45.7±20.2, FVC:%63.5±22.2, PaO2:66.3±15.0mmHg, PaCO2:43.9±8.3mmHg, laktat: 1.5±0.6 mmol/L idi. On iki olgu(%11.7) A, 16 olgu(%15.5) B, 25 olgu (%24.3) C, 50 olgu (%48.5) D grubunda idi. Olguların %47.6’sı (n=49) USOT, %37.3’ü (n=28) NİMV kullanmakta idi. D kategorisindeki olgularda laktat düzeyi A, B, C sınıflarına göre belirgin yüksekti (p

LACTATE LEVEL IN STABLE COPD PATIENTS

Lactate level is an indicator of tissue oxygenation. It might be valuable for COPD patients to have a prognostic marker. Thus, we aimed to evaluate the relationship between lactate level and COPD classification, FEV1 level, exacerbations, hypoxemia in stable COPD patients. In this retrospective study, demographics, arterial blood gas analysis, exacerbation history, GOLD classification, pulmonary function tests, long-term oxygen therapy (LTOT) and non-invasive mechanical ventilation (NIMV) usage in stable COPD patients were recorded. Totally 103 patients (M / F: 90/13, mean age: 66.8 ± 8.0years) were included. Mean FEV1:45±20%, FVC: 63±22%, PaO2:66±15mmHg, PaCO2:43±8mmHg, lactate level: 1.5±0.6mmol/L. The groups of the patients according to GOLD COPD classification were as follows;; 11.7%, 15.5%, 24.3%, 48.5% in A,B,C,D, respectively. Of patients 47.6% were using LTOT and 37.3% were using NIMV. Lactate level of the patients in category D was significantly higher than the patients in A, B, C categories (p

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