Ayca TURER CABBAR, Mustafa Aytek ŞİMŞEK, Burak HÜNÜK, Olcay ÖZVEREN, Özge GÜZELBURÇ, Muzaffer DEĞERTEKIN

EVALUATION OF THE RELATIONSHIP BETWEEN MPV AND SEVERITY OF CORONARY ARTERY DISEASE IN TYPE 2 DIABETIC PATIENTS WITHOUT ACUTE CORONARY SYNDROME

Since many studies focused on the relationship between mean platelet volume (MPV) and severity of type 2 diabetes mellitus (T2DM) or investigated MPV and coronary artery disease (CAD) mostly on acute coronary syndrome (ACS), this study primarily focused to investigate if MPV values have any relation withdifferent levels of CAD specifically in T2DM patients, who had no previous coronary artery disease, and no ACS history.T2DM patients who had first coronary angiography (CAG) between November 2019 and February 2020, and whose after night fasting blood tests were performed before CAG were included. Two cardiologists, blinded to the patients, evaluated angiographies. Patients have divided into groups accordingly; normal coronary artery (Group 1), non-critic stenosis (Group II), and severe CAD (Group III) according to the Gensini score. Patients’ demographics, heart rate, risk factors of CAD, and blood test including MPV were also collected.A total of 180 patients (88 female, 92 male) were involved in the study. There was no significant relation between MPV and the severity of CAD in T2DM patients (p=0.228). The mean age of the Group I group was significantly lower than in other groups (p=0.228), and there were significantly lower males in Group I than other groups (p=0.0001). The triglycerides levels were significantly low in Group I than in other groups (p=0.021 and p=0.006).MPV values were not associated with the severity of CAD in stable patients. Older age, male gender, higher levels of triglycerides, and initial glucose levels were significantly related to the severity of CAD in T2DM patients.

AKUT KORONER SENDROM OLMAYAN TİP 2 DİYABETİK HASTALARDA KORONER ARTER HASTALIĞI YAYGINLIĞI İLE MPV İLİŞKİSİNİN ARAŞTIRILMASI

Birçok çalışma, ortalama trombosit hacmi (MPV) ile tip 2 diabetes mellitus (T2DM) şiddeti arasındaki ilişkiye odaklanmakta veya MPV ve koroner arter hastalığı (KAH) çoğunlukla akut koroner sendrom (AKS) hastaları üzerinde gerçekleştirilmektedir. Bu çalışma öncelikle koroner arter hastalığı ve AKS öyküsü olmayan T2DM hastalarında MPV değerlerinin farklı derecelerdeki KAH ile ilişkisi araştırılmıştır. Kasım 2019 ile Şubat 2020 tarihleri arasında ilk koroner anjiyografi (CAG) yaptıran ve CAG öncesi gece açlık kan testleri yapılan T2DM hastaları dahil edildi. Anjiyografiler iki kardiyolog değerlendirdi. Hastalar bu bulgular ve Gensini skoruna göre; normal koroner arter (Grup 1), kritik olmayan darlık (Grup II) ve ciddi KAH (Grup III) olarak 3 gruba ayrıldı. Hastaların demografik verileri, kalp atış hızı, CAD risk faktörleri ve MPV dahil kan testleri değerlendirildi. Çalışmaya toplam 180 hasta (88 kadın, 92 erkek) dahil edildi. T2DM hastalarında MPV ile KAH şiddeti arasında anlamlı bir ilişki bulunmadı (p=0,228). Grup I grubunun ortalama yaşı diğer gruplardan anlamlı olarak daha düşüktü (p=0,228). Grup I'de diğer gruplara göre anlamlı oranda düşük sayıda erkek vardı (p=0,0001). Trigliserid düzeyleri Grup I'de diğer gruplara göre anlamlı olarak düşüktü (p=0,021 ve p=0,006). MPV değerleri stabil hastalarda KAH şiddeti ile ilişkili bulunmadı. T2DM hastalarında ileri yaş, erkek cinsiyet, yüksek trigliserit seviyeleri ve başlangıç glikoz seviyeleri, KAH şiddeti ile önemli ölçüde ilişkiliydi.

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