Primary duodenal mucosa-associated lymphoid tissue (MALT) lymphoma is the most rarely seen type of non-Hodgkin lymphoma and is diagnosed most commonly in the stomach. A 20-year-old male patient presented with progressive vomiting, weight loss, and abdominal pain. There was nothing remarkable on 2 consecutive gastroduodenoscopies, but his complaints persisted. A double-contrast barium examination was performed, which revealed a filling defect in the duodenum. A biopsy specimen from the patient determined the presence of Helicobacter pylori and the patient was diagnosed with poorly-differentiated B-cell MALT lymphoma Successful chemotherapy and H. pylori eradication therapy were performed and follow-up revealed no recurrence
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