Salmonella Enteritidis Empyema Preceding the Diagnosis of Non-Hodgkin's Lymphoma and Subsequent Contralateral Chylothorax Treated with Radiolabeled Rituximab

Salmonella infection is common, but pleural involvement has rarely been reported. Only seven cases of Salmonella enteritidis pleural empyema have been reported; all had an associated preexisting underlying immunosuppresion or malignancy. We report the case of an apparently healthy man who developed S. enteritidis empyema. On further follow-up and surveillance, he eventually presented with non-Hodgkin's lymphoma and a contralateral recurrent chylothorax. The latter was successfully controlled with radiolabeled rituximab, which has never been described for the above purpose in literature before


Cohen JI, Bartlett JA, Corey GR. Extra-intestinal manifestations of Salmo- nella infections. Medicine (Baltimore) 1987; 66: 349-88. [CrossRef]

Saphra I, Winter JW. Clinical Manifestations of Salmonellosis in Man: An Evaluation of 7779 Human Infections Identified at the New York Salmonel- la Center. N Engl J Med 1957; 256: 1128-34. [CrossRef]

Brims FJH, Rosenstengal A, Yogendran A, Lee F, Franke A, Reid C. The bacte- riology of pleural infection in Western Australia. Proceedings from Abstract Poster in American Thoracic Society Meeting San Diego, May 16-21, 2014.

De Lope ML, Batalha P, Sosa M, Rodriguez-Gomez F J, Sanchez-Munoz A, Pujol E et al. Pleural Empyema due to Salmonella enteritidis in a non-immunocom- promised patient. Eur J Clinical Microbiol Infect Dis 2004; 23: 792-3. [CrossRef]

Crum NF. Non-typhi Salmonella empyema: case report and review of the literature. Scand J Infect Dis 2005; 37: 852-7. [CrossRef]

Cistulli PA, Barnes DJ, Young GA. Salmonella empyema in a patient with lymphoma. Aust N Z J Med 1991; 21: 246-7. [CrossRef]

Lenhard RE Jr, Densen P, Lenhard RE. Salmonella empyema and Hodgkin's disease. South Med J 1975; 68: 363-6. [CrossRef]

Brims FJ, Lansley SM, Waterer GW, Lee YC. Empyema thoracis: new insights into an old disease. Eur Respir Rev 2010; 19: 220-8. [CrossRef]

Piccolo F, Pitman N, Bhatnagar R, Popowicz N, Smith NA, Brockway B et al. . Intrapleural tissue plasminogen activator and deoxyribonuclease for pleu- ral infection. An effective and safe alternative to surgery. Ann Am Thorac Soc 2014; 11: 1419-25. [CrossRef]

Leahy MF, Seymour JF, Hicks RJ, Turner JH. Multicenter phase II clinical study of Iodine-131- rituximab radioimmunotherapy in relapsed or refra- ctory indolent non hodgkin's lymphoma. J Clin Oncol 2006; 24: 4418-25. [CrossRef]

Eurasian J Pulmonol 2015; 17: 176-8

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