Obstrüktif uyku apne sendromlu (OUAS) hastalarda kardiyovasküler hastalıklar için risk faktörü olan c-reaktif protein ve homosistein düzeyleri

Amaç: C-reaktif protein (CRP) ve homosistein aterosklerozis ve koroner arter hastalıkları için önemli risk faktörleridir. Bu çalışmada, OUAS'lı hastalar ile vücut kitle indeksi, yaş ve cinsiyet olarak eşleştirilmiş kontrol grubu arasında, ek hastalık, ilaç kullanma ve sigara içme durumlarının etkisini de dışlayarak, CRP ve homosistein seviyelerini ve bunların ilişkili olduğu parametreleri araştırmayı amaçladık. Gereç ve yöntem: Bu çalışma Ocak 2006-Ocak 2009 tarihleri arasında, bir vaka-kontrol çalışması olarak yürütüldü. OUAS şüphesi olan, 987 erkek hastaya gece boyu polisomnografi yapıldı. Dışlama kriterleri uygulandıktan sonra 230 kişi CRP ve homosistein ölçümleri için uygun bulundu. Vakalar apne-hipopne indeksine (AHİ) göre sınıflandırıldı: 36 kontrol (AHİ

C-reactive protein and homocysteine levels which are the risk factors of cardiovascular diseases for patients with obstructive sleep apnea syndrome (OSAS)

Aim: C-reactive protein (CRP) and homosystein are important risk factors for atherosclerosis and coronary hearth disease. We aimed to investigate the serum levels of CRP and homocysteine and related clinical parameters among the patients with OSAS and the control group who were matched for age, gender, body mass indeks (BMI), by excluding the effects of the co-existing disease, being on medication and smoking. Material and methods: This study was conducted between January 2006-January 2009, as a case-control study. 987 consecutive patients who were reffered for suspected OSAS underwent polisomnography. 230 subject were found suitable for CRP and homosistein measurement after application of the exclusion criterias. Cases were classified according to apnea-hypopnea index (AHI); 84 of them mild-moderate OSAS (30<AHI<5); 110 of them severe OSAS (AHI>30) and 36 of them control cases (AHI<5). To eliminate the statistical differences bet-ween groups in body mass index, 10 overweight cases of severe OSAS group were excluded from the study. Venous blood samples were taken between 7.00-8.00 am. Results: Plasma CRP level in both groups with OSAS was detected as significantly higher than in control group (p<0.001). However, a difference bet-ween the groups in terms of the levels of homocysteine was not detected (p=0.163). In step-wise regression analysis, the variables, actually explaining the increase in the levels of CRP were waist circumference (p=0.220 p=0.002) and the time passed in 90 and upper saturation (p=-0.145, p=0.039), levels of homosistein were inde-pendently associated with mesurments of Epworth sleepiness scale (b=0.160 p=0.015). Conclusion: We found that the patients with OSAS had low level inflammation determined by the level of CRP and this was related to the time passed in 90 and upper saturation at night and waist circumference. Otherwise, OSAS does not seem to create a cardiovascular risk because of increased homosistein.

Kaynakça

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Kaynak Göster

Solunum
  • ISSN: 1302-4922
  • Yayın Aralığı: Yılda 0 Sayı
  • Başlangıç: 2018

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