Histoplasma capsulatum, which is the causative agent of histoplasmosis, appears in the soil globally. There are a limited number of histoplasmosis cases reported from Turkey. In this article, we present a patient with Histoplasma pneumonia developed during corticosteroid treatment. A 70-year-old female with invasive ductal carcinoma was admitted to our department with shortness of breath, cough, and weakness. Her clinical and radiological findings were compatible with radiation pneumonitis. Computed tomography of thorax (Thoracic CT) revealed scattered and patchy areas of consolidation, ground-glass opacities, and ground-glass density nodules in all lobes of the lungs. Transthoracic tru-cut biopsy was performed under CT guidance. Histopathological examination showed microorganisms morphologically consistent with Histoplasma became apparent with silver stain in the alveolar lumen. Patient was treated with itraconazole for 6 months. She responded well to the treatment with a complete clinical and radiological regression. Histoplasmosis is a worldwide disease. It should be noted that pulmonary histoplasmosis could be seen in our country. Because of this, pulmonary histoplasmosis should be kept in mind in immunocompromised patients as an opportunistic pulmonary infection in our country
Euzéby J. Mycologie médicale comparée : les mycoses des animaux et leurs relations avec les mycoses de l'homme. Lyon: Éditions Fondation Marcel Merieux; 1992. pp. 452.
Yücel A, Kantarcıoğlu S. Histoplasma capsulatum'un epidemiyolojisi. Tur- kiye Parazitol Derg 1999; 23: 56-61.
Yücel A, Kantarcıoğlu AS. Türkiye'de doğada varlığı kanıtlanan histoplas- ma capsulatum: önemi. Cerrahpaşa Tıp Dergisi 2002; 33: 69-74.
Deepe Jr GS. Histoplasma capsulatum (Histoplasmosis). In: Blaser JEBDJ, editor. Mandell, Douglas and Bennett's Principles and Practice of Infec- tious Diseases. 8th ed. Philadelphia: Elsevier Saunders; 2015.p.2949-62. e1.
Hage CA, Ribes JA, Wengenack NL, Baddour LM, Assi M, McKinsey DS, et al. A multicenter evaluation of tests for diagnosis of histoplasmosis. Clin Infect Dis 2011; 53: 448-54. [CrossRef]
Hage CA, Davis TE, Fuller D, Egan L, Witt JR, 3rd, Wheat LJ, et al. Diagno- sis of histoplasmosis by antigen detection in BAL fluid. Chest 2010; 137: 623-8. [CrossRef]
Goodwin RA, Jr., Owens FT, Snell JD, Hubbard WW, Buchanan RD, Terry RT, et al. Chronic pulmonary histoplasmosis. Medicine (Baltimore) 1976; 55: 413-52. [CrossRef]
Riviere S, Denis B, Bougnoux ME, Lanternier F, Lecuit M, Lortholary O. Se- rum Aspergillus galactomannan for the management of disseminated histoplasmosis in AIDS. Am J Trop Med Hyg 2012; 87: 303-5. [CrossRef]
Kurowski R, Ostapchuk M. Overview of histoplasmosis. Am Fam Physi- cian 2002; 66: 2247-52.
Bahr NC, Antinori S, Wheat LJ, Sarosi GA. Histoplasmosis infections worldwide: Thinking outside of the Ohio River Valley. Curr Trop Med Rep 2015; 2: 70-80. [CrossRef]