___

• Pollack MH, Otto MW, Roy-Byrne PP, Coplan JD, Rothbaum BO, Simon NM et al. Novel treatment approaches for refractory anxiety disorders. Depress Anxiety 2008;25:467-76.
• Hoffman EJ, Mathew SJ. Anxiety disorders: a comprehensive review of pharmacotherapies. Mt Sinai J Med 2008; 75:248-62.
• Mula M, Pini S, Cassano GB. The role of anticonvulsant drugs in anxiety disorders: a critical review of the evidence. J Clin Psychopharmacol 2007; 27:263-72.
• Mc Donald JW, Garofalo E, Hood T, Sackellares JC, Gilman S, McKeever PE et al. Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy. Ann Neurol 1991; 29:529-541.
• Henry TR, Frey KA, Sackellares JC, Gilman S, Koeppe RA, Brunberg JA et al. In vivo cerebral metabolism and central benzodiazepine –receptor binding in temporal lobe epilepsy. Neurology 1993; 43:1998-2006.
• Jackson GD, McIntosh AM, Briellmann RS, Berkovic SF. Hippocampal sclerosis studied in identical twins. Neurology 1998; 51:78-84.
• White MF, Fothergill-Gilmore LA, Kelly SM, Price NC Dissociation of the tetrameric phosphoglycerate mutase from yeast by a mutation in the subunit contact region. Biochem J 1993; 295:743-8.
• Ișık E, Ișık Taner Y. Çocuk, Ergen ve Erișkinlerde Anksiyete Bozuklukları. 1.basım, İstanbul, Golden Print. 2006; 35-6.
• Paré D. Role of the basolateral amygdala in memory consolidation. Prog Neurobiol 2003; 70:409-20.
• Rezaki M. Anksiyetede nöral devreler. Dilbaz N, ed. Anksiyete bozukluklarında son gelișmeler. 1. basım, Ankara, Pozitif Matbaacılık. 2005; 189-190.
• Elzinga BM, Schmahl CG, Vermetten E, van Dyck R, Bremner JD. Higher cortisol levels following exposure to traumatic reminders in abuse-related PTSD. Neuropsychopharmacology 2003; 28:1656-65.
• Stahl SM. Temel Psikofarmakoloji Nörobilimsel Temeli ve Pratik Uygulamaları. Taneli B, Taneli Y, Çeviri ed. 1. baskı, İstanbul, FSF Matbaacılık. 2003; 309-319.
• Neumeister A, Bone O, Charney DS. Anxiety disorders: neurochemical aspects. Sadock BJ, Sadock VA, eds. Kaplan & Sadock’s comprehensive textbook of psychiatry. 8nd ed., Philadelphia, Lippincott Williams & Wilkins. 2005; 1739- 1748.
• Sanders SK, Shekhar A. Blockade of GABA A receptors in the region of the anterior basolateral amygdala of rats elicits increases in heart rate and blood pressure. Brain Res 1991; 567:101-110.
• Aroniadou-Anderjaska V, Qashu F, Braga MF. Mechanisms regulating GABAergic inhibitory transmission in the basolateral amygdala: implications for epilepsy and anxiety disorders. Amino Acids 2007; 32:295-297.
• Rodríguez Manzanares PA, Isoardi NA, Carrer HF, Molina VA. Previous stress facilitates fear memory, attenuates GABAergic inhibition, and increases synaptic plasticity in the rat basolateral amygdala. J Neurosci 2005; 25:8725- 8734.
• Kalueff AV, Nutt DJ. Role of GABA in anxiety and depression. Depress Anxiety 2007; 24:495-517.
• Eșkazan E, Onat F. Beynin nörofizyolojik organizasyonu ve deneysel epilepsi modelleri. Özkara Ç, Ataklı D ed. Epilepsi. 1. basım, İstanbul, 5 Us Yayınları. 2002; 63-90.
• Li H, Chen A, Xing G, Wei ML, Rogawski MA. Kainate receptor mediated heterosynaptic facilitation in the amygdala. Nat Neurosci 2001; 4:612–620.
• Kaminski RM, Banerjee M, Rogawski MA. Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology 2004; 46:1097-104.
• Morris JS, Friston KJ, Büchel C, Frith CD, Young AW, Calder AJ et al. A neuromodulatory role for the human amygdala in processing emotional facial expressions. Brain 1998; 121:47-57.
• Villarreal G, King CY. Brain imaging in posttraumatic stress disorder. Semin Clin Neuropsychiatry 2001; 6:131-45.
• Johannessen LC. Antiepileptic drugs in non-epilepsy disorders: relations between mechanisms of action and clinical efficacy. CNS Drugs 2008; 22:27
• Ketter TA, Post RM, Theodore WH. Positive and negative psychiatric effects of antiepileptic drugs in patients with seizure disorders. Neurology 1999; 53 Suppl 53- 67.
• Eșkazan E, Onat F. Epilepsinin medikal tedavisi. Bora İ, Yeni S, Gürses C ed. Epilepsi. 1. baskı, İstanbul, Nobel Matbaacılık. 2008; 595-607.
• Singh V, Muzina DJ, Calabrese JR. Anticonvulsants in bipolar disorder. Psychiatr Clin North Am 2005; 28:301-23.
• Perucca E. Clinical pharmacology and therapeutic use of the new antiepileptic drugs. Fundam Clin Pharmacol 2001; 15:405-417.
• Zwanzger P, Baghai TC, Schuele C, Ströhle A, Padberg F, Kathmann N et al. Vigabatrin decreases cholecystokinin-tetrapeptide (CCK-4) induced panic in healthy volunteers. Neuropsychopharmacology 2001; 25:699-703.
• Jefferson JW. Lamotrigine in psychiatry: pharmacology and therapeutics. CNS Spectr 2005; 10:224-232.
• Shiloh R, Stryjer R, Weizman A, Nutt D. Duygudurum dengeleyicisi benzeri ilaçlar. Kırlı S çev. ed. Psikiyatrik ilaç tedavisi atlası. 2. baskı, İstanbul, Ömür Matbaacılık. 2008; 59.
• Borden LA, Murali Dhar TG, Smith KE, Weinshank RL, Branchek TA, Gluchowski C. Tiagabine, SK&F 89976-A, CI- 966, and NNC- 711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol 1994; 269:219-224.
• Dooley DJ, Donovan CM, Meder WP, Whetzel SZ. Preferential action of gabapentin and pregabalin at P/Q-type voltage-sensitive calcium channels: inhibition of K+-evoked [3H]-norepinephrine release from rat neocortical slices. Synapse 2002; 45:171-190.
• Kelly KM. Gabapentin; antiepileptic mechanism of action. Neuropsychobiology 1998; 38:139-144.
• Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci U S A 2004; 101:9861–9866.
• Crowder KM, Gunther JM, Jones TA, Hale BD, Zhang HZ, Peterson MR et al. Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A). Proc Natl Acad Sci U S A 1999; 96:15268-15273.
• Hitiritis N, Brodie MJ: Modern antiepileptik ilaçlar: tedavi kılavuzları ve ötesi. Curr Opin Neurol (Türkçe baskı) 2006; 19:175-180.
• Dooley DJ, Donovan CM, Pugsley TA. Stimulus-dependent modulation of [3H]norepinephrine release from rat neocortical slices by gabapentin and pregabalin. J Pharmacol Exp Ther 2000; 295:1086–1093.
• Pande AC, Crockatt JG, Feltner DE, Janney CA, Smith WT, Weisler R et al. Pregabalin in generalized anxiety disorder: a placebo-controlled trial. Am J Psychiatry 2003; 160:533-540.
• Rickels K, Pollack MH, Feltner DE, Lydiard RB, Zimbroff DL, Bielski RJ et al. Pregabalin for treatment of generalized anxiety disorder a 4-week, multicenter, double- blind, placebo- controlled trial of pregabalin and alprazolam. Arch Gen Psychiatry 2005; 62:1022-1030.
• Pohl RB, Feltner DE, Fieve RR, Pande AC. Efficacy of pregabalin in the treatment of generalized anxiety disorder: double-blind, placebo-controlled comparison of BID versus TID dosing. J Clin Psychopharmacol 2005; 25:151
• Feltner DE, Crockatt JG, Dubovsky SJ, Cohn CK, Shrivastava RK, Targum SD et al. A randomized, double-blind, placebo-controlled, fixed-dose, multicenter study of pregabalin in patients with generalized anxiety disorder. J Clin Psychopharmacol 2003; 23:240-249.
• Bech P. Dose-response relationship of pregabalin in patients with generalized anxiety disorder. A pooled analysis of four placebo-controlled trials. Pharmacopsychiatry 2007; 40:163-168.
• Feltner D, Wittchen HU, Kavoussi R, Brock J, Baldinetti F, Pande AC. Long-term efficacy of pregabalin in generalized anxiety disorder. Int Clin Psychopharmacol 2008; 23:18-28.
• Rosenthal M. Tiagabine for the treatment of generalized anxiety disorder: a randomized, open-label, clinical trial with paroxetine as a positive control. J Clin Psychiatry 2003; 64:1245-1249.
• Pollack MH, Roy-Byrne PP, Ameringen MV, Snyder H, Brown C, Ondrasik J et al. The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study. J Clin Psychiatry 2005; 66:1401-1408.
• Pollack MH, Tiller J, Xie F, Trivedi MH. Tiagabine in adult patients with generalized anxiety disorder results from 3 randomized, double-blind, placebo-controlled, parallel-group studies. J Clin Psychopharmacol 2008; 28:308-316.
• Pande AC, Feltner DE, Jefferson JW, Davidson JR, Pollack M, Stein MB et al. Efficacy of the novel anxiolytic pregabalin in social anxiety disorder: a placebo-controlled, multicenter study. J Clin Psychopharmacol 2004; 24:141- 149.
• Tassone DM, Boyce E, Guyer J, Nuzum D. Pregabalin: a novel gamma- aminobutyric acid analogue in the treatment of neuropathic pain, partial- onset seizures, and anxiety disorders. Clin Ther 2007; 29:26-48.
• Pande AC, Davidson JR, Jefferson JW, Janney CA, Katzelnick DJ, Weisler RH et al. Treatment of social phobia with gabapentin: a placebo-controlled study. J Clin Psychopharmacol 1999; 19:341-348.
• Dunlop BW, Papp L, Garlow SJ, Weiss PS, Knight BT, Ninan PT. Tiagabine for social anxiety disorder. Hum Psychopharmacol 2007; 22:241-244.
• Kinrys G, Pollack MH, Simon NM, Worthington JJ, Nardi AE, Versiani M. Valproic acid for the treatment of social anxiety disorder. Int Clin Psychopharmacol 2003; 18:169–172.
• Van Ameringen M, Mancini C, Pipe B, Oakman J, Bennett M. An open trial of topiramate in the treatment of generalized social phobia. J Clin Psychiatry 2004; 65: 1674-1678.
• Simon NM, Worthington JJ, Doyle AC, Hoge EA, Kinrys G, Fischmann D et al. An open-label study of levetiracetam for the treatment of social anxiety disorder. J Clin Psychiatry 2004; 65:1219-1222.
• Zhang W, Connor KM, Davidson JR. Levetiracetam in social phobia: a placebo controlled pilot study. J Psychopharmacol 2005; 19:551-553.
• Pollack MH, Jensen JE, Simon NM, Kaufman RE, Renshaw PF. High-field MRS study of GABA, glutamate and glutamine in social anxiety disorder: response to treatment with levetiracetam. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32: 739-743.
• Taylor FB. Tiagabine for posttraumatic stress disorder: a case series of 7 women. J Clin Psychiatry 2003; 64:1421-1425.
• Connor KM, Davidson JR, Weisler RH, Zhang W, Abraham K. Tiagabine for posttraumatic stress disorder: effects of open-label and double-blind discontinuation treatment. Psychopharmacology (Berl) 2006; 184:21-25.
• Davidson JR, Brady K, Mellman TA, Stein MB, Pollack MH. The efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder. J Clin Psychopharmacol 2007; 27:85-88.
• Brannon N, Labbate L, Huber M. Gabapentin treatment for posttraumatic stress disorder. Can J Psychiatry 2000; 45:84.
• Hamner MB, Brodrick PS, Labbate LA. Gabapentin in PTSD: A retrospective, clinical series of adjunctive therapy. Ann Clin Psychiatry 2001; 13:141-146.
• Davis LL, Davidson JR, Ward LC, Bartolucci A, Bowden CL, Petty F. Divalproex in the treatment of posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial in a veteran population. J Clin Psychopharmacol 2008; 28: 84-88.
• Hertzberg MA, Butterfield MI, Feldman ME, Beckham JC, Sutherland SM, Connor KM et al. A preliminary study of lamotrigine for the treatment of posttraumatic stress disorder. Biol Psychiatry 1999; 45:1226-1229.
• Berlant J, van Kammen DP. Open-label topiramate as primary or adjunctive therapy in chronic civilian posttraumatic stress disorder: a preliminary report. J Clin Psychiatry 2003; 64:219-220.
• Berlant JL. Prospective open-label study of add-on and monotherapy topiramate in civilians with chronic nonhallucinatory posttraumatic stress disorder. BMC Psychiatry 2004; 4:24.
• Tucker P, Trautman RP, Wyatt DB, Thompson J, Wu SC, Capece JA et al. Efficacy and safety of topiramate monotherapy in civilian posttraumatic stress disorder: a randomized, double-blind, placebo-controlled study. J Clin Psychiatry 2007; 68:201-206.
• Lindley SE, Carlson EB, Hill K. A randomized, double-blind, placebo-controlled trial of augmentation topiramate for chronic combat-related posttraumatic stress disorder. J Clin Psychopharmacol 2007; 27:677-681.
• Primeau F, Fontaine R, Beauclair L. Valproic acid and panic disorder. Can J Psychiatry 1990; 35:248-250.
• Woodman CL, Noyes R Jr. Panic disorder: treatment with valproate. J Clin Psychiatry 1994; 55:134-136.
• Baetz M, Bowen RC. Efficacy of divalproex sodium in patients with panic disorder and mood instability who have not responded to conventional therapy. Can J Psychiatry 1998; 43:73-77.
• Pollack MH, John M, Erin LS. Gabapentin as a potential treatment for anxiety disorders. Am J Psychiatry 1998; 155:992-993.
• Pande AC, Pollack MH, Crockatt MA, Greiner M, Chouinard G, Lydiard RB et al. Placebo-controlled study of gabapentin treatment of panic disorder. J Clin Psychopharmacol 2000; 20:467-471.
• Spila B, Szumiłło A. Gabapentin (GBP) in panic disorders--case report. Psychiatr Pol 2006; 40:1061-1068.
• Sheehan DV, Sheehan KH, Raj BA, Janavs J. An open-label study of tiagabine in panic disorder. Psychopharmacol Bull 2007; 40:32-40.
• Papp LA. Safety and efficacy of levetiracetam for patients with panic disorder: results of an open-label, fixed-flexible dose study. J Clin Psychiatry 2006; 67:1573-1576.
• Zwanzger P, Baghai TC, Schuele C, Ströhle A, Padberg F, Kathmann N et al. Vigabatrin decreases cholecystokinin-tetrapeptide (CCK-4) induced panic in healthy volunteers. Neuropsychopharmacology 2001; 25:699-703.