Hydroxyapatite Coating on Ti6Al4V Alloy Surface Through Biomimetic Method Using Glycolic Acid - Sodium Gluconate Buffer System and Examination of Properties of the Coating

The use of implant materials is one of the important surgical interventions in the treatment of disorders that are congenital and acquired deformities in musculoskeletal system. Metallic biomaterials within these implant materials are often preferred because of their proximity to the mechanical properties of the bone. In the implantation process, the surfaces of these alloys are coated with ceramic based biomaterials to increase the bioactivity and biocompatibility properties. In this study, it is aimed to create hydroxyapatite (HA) coating that is completely harmonious with human blood plasma environment, on Ti6Al4V alloy, using glycolic acid - sodium gluconate buffer system with biomimetic method for the first time in literature. Coating was realised inside synthetic body fluid (SBF) with waiting periods of 24, 48, 72 and 96 hours. Relating to the coatings, surface smoothness and thickness specifications have been determined, their micro structure has been analysed by Scanning Electron Microscope (SEM), the elementary analyses namely Energy Dispersive X-ray Spectroscopy (EDS) for the surfaces of coating have been determined and X-Ray Diffraction (XRD) analysis have been conducted for obtaining the concentrations of the phases. As a result of the experiments, successful surface smoothness values and ratio of Ca/P close to optimal value have been obtained. Additionally, the presence of HA crystals with intense phase structure, with compact and homogeneous distribution on the substrate have been observed.

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1. Özkurt B. and Tabak A. Y., “Metallic biomaterials and metallozis”, Journal of TOTBİD, 10(2): 83-86, (2011). 2. Pasinli A. and Aksoy R. S., “Hydroxyapatite for artificial bone applications”, Biotechnology Magazine, 1: 41-51, (2010). 3. Aydın İ., “An investigation of fracture and wear behavior of HA coatings deposited onto Ti6Al4V alloys in a new environment”, PhD Thesis, Celal Bayar University, Institute of Science, (2013). 4. Aydın İ., Çetinel H., Pasinli A. and Yüksel M., “Fracturing and adhesion behavior of hydroxyapatite formed by a citric acid and sodium citrate buffer system”, Materials Testing, 58(2): 1 - 6, (2016). 5. Pasinli A., “Hydroxyapatite for artificial bone applications”, Electronic Journal of Machine Technologies, 25 - 35, (2004). 6. Kokubo T., Kim H. M., Miyaji F., Takadama H. and Miyazaki T., “Ceramic-metal and ceramic-polymer composites prepared by a biomimetic process”, Composites Part A, Applied Science and Manufacturing, 30: 405–409, (1999). 7. Taş A. C., “Synthesis of biomimetic Ca-hydroxyapatite powders at 37 ºC in synthetic body fluids”, Biomaterials, 21: pp. 1429–1438, (2000) 8. Sepahvandi A., Moztarzadeh F., Mozafari M., Ghaffari M., and Raee N., “Photoluminescence in the characterization and early detection of biomimetic bone-like apatite formation on the surface of alkaline-treated titanium implant”, State of the art. Biointerfaces, 86: 390-396, (2011). 9. Faure J., Balamurugan A., Benhayoune H., Torres P., Balossier G. and Ferreira J. M. F., “Morphological and chemical characterization of biomimetic bone like apatite formation on Ti6Al4V titanium alloy”, Materials Science and Engineering, 29: 1252-1257, (2009). 10. Li F., Feng Q. L., Cui F. Z., Li H. D. and Schubert H., “A simple biomimetic method for calcium phosphate coating”, Surface & Coating Technology, 154: 88–93, (2002). 11. Xiaobo C., Yuncang L., Peter D. H. and Cui’e W., “Microstructures and bond strengths of the calcium phosphate coatings formed on titanium from different simulated body fluids”, Materials Science and Engineering, 29: 165-171, (2009). 12. Pasinli A., Yüksel M., Çelik E., Şener S. and Taş C. A., “A new approach in biomimetic synthesis of calcium phosphate coatings using lactic acid-Na lactate buffered body fluid solution”, Acta Biomaterialia, 6: 2282-2288, (2010). 13. Çağlayan M. E., “Hydroxyapatite coating of Ti6A14V alloys in alanin - alanine sodium salt environment with biomimetic method and observing of some features”, M.Sc. Thesis, Celal Bayar University, Institute of Science, (2016). 14. Kırman M., “Coating Ti6Al4V alloy by hydroxyapatite through biomimetic method using aminoacetic acid - sodium aminoacetate buffer system and examination of features of the coating”, M.Sc. Thesis, Celal Bayar University, Institute of Science, (2016). 15. Hayakawa T., Yoshinari M., Kiba H., Yamamoto H., Nemoto K., Jansen J. A., “Trabecular bone response to surface roughened and calcium phosphate (Ca-P) coated titanium implants”, Biomaterials, 23: 1025–1031, (2002). 16. Yoshinari M., Oda Y., Inoue T., Matsuzaka K., Shimono M., “Bone response to calcium phosphate coated and bisphosphonate immobilized titanium implants”, Biomaterials, 23: 2879 – 2885, (2002). 17. Citeau A., Guicheux J., Vinatier C., Layrolle P., Nguyen T. P., Pilet P. and Daculsi G., “In vitro biological effects of titanium rough surface obtained by calcium phosphate grid blasting”, Biomaterials, 26: 157 – 165, (2005). 18. Aydın İ., Çetinel H., Pasinli A., and Yüksel M., “Preparation of hydroxyapatite coating by using citric acid sodium citrate buffer system in the biomimetic procedure”, Materials Testing, 58(2): 140 – 145, (2013). 19. Aydın İ., Çaglayan M. E. and Pasinli A., “Hydroxyapatite coating of Ti6Al4V alloys in alanin - alanine sodium salt environment with biomimetic method”, Celal Bayar University Journal of Science, 12(2): 201 – 207, (2016). 20. Aydın İ., Kırman M. and Pasinli A., “Coating Ti6Al4V alloy by hydroxyapatite through biomimetic method using aminoacetic acid - sodium aminoacetate buffer system and examination of features of the coating“, 1st International Mediterranean Science and Engineering Congress, 26 - 28 October, Adana, Turkey, (2016). 21. Şimşek F. A., “Chemical preparation of calcium hydroxyapatite in synthetic body fluids at 37 °C and its use for coating some metal surfaces”, M.Sc. Thesis, Middle East Technical University, Institute of Science, 1-107, (1997). 22. Nagano M., Kitsugi T., Nakamura T., Kokuba T. and Tanahashi M., “Bone bonding ability of an apatite coated polymer produced using a biomimetic method: A mechanical and histological study in vivo”, Journal of Biomedical Materials Research Part A, 32: 487-494, (1996). 23. Urist M. R., Lietze A. and Dawson E., “β tricalcium delivery system for bone morphogenetic protein”, Clinical Orthopedics and Related Research, 187: 227-280, (1984). 24. Despina D. Deligianni, Nikoleta D. Katsala, Petros G. Koutsoukos and Yiannis F. Missirlis., “Effect of surface roughness of hydroxyapatite on human bone marrow cell adhesion, proliferation, dilerentiation and detachment strength”, Biomaterials, 22: 87 – 96, (2001). 25. Han J. K., Song H.Y., Saito F. and Lee B. T., “Synthesis of high purity nano-sized hydroxyapatite powder by microwave-hydrothermal method”, Materials Chemistry and Physics, 99: 235 – 239, (2006). 26. Takadama H., Kim H. M., Kukuba T. and Nakamura T., “TEM-EDX study of mechanism of bonelike apatite formation on bioactivite titanium metal in simulated body fluid”, Journal of Biomedical Materials Research, 57: 441 – 448, (2001). 27. Barrere F., Van Blitterswijk C. A., Groot K. and Layrolle P., “Influence of ionic strength and carbonate on the Ca-P coating formation from SBFx5 solution”, Biomaterials, 23: 1921 – 1930, (2002).

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Bibtex @araştırma makalesi { politeknik369141, journal = {Politeknik Dergisi}, eissn = {2147-9429}, address = {Gazi Üniversitesi Teknoloji Fakültesi 06500 Teknikokullar - ANKARA}, publisher = {Gazi Üniversitesi}, year = {2017}, volume = {20}, number = {4}, pages = {993 - 1001}, doi = {10.2339/politeknik.369141}, title = {Hydroxyapatite Coating on Ti6Al4V Alloy Surface Through Biomimetic Method Using Glycolic Acid - Sodium Gluconate Buffer System and Examination of Properties of the Coating}, key = {cite}, author = {Aydın, İbrahim and Engin, Ferdi} }
APA Aydın, İ. & Engin, F. (2017). Hydroxyapatite Coating on Ti6Al4V Alloy Surface Through Biomimetic Method Using Glycolic Acid - Sodium Gluconate Buffer System and Examination of Properties of the Coating . Politeknik Dergisi , 20 (4) , 993-1001 . DOI: 10.2339/politeknik.369141
MLA Aydın, İ. , Engin, F. "Hydroxyapatite Coating on Ti6Al4V Alloy Surface Through Biomimetic Method Using Glycolic Acid - Sodium Gluconate Buffer System and Examination of Properties of the Coating" . Politeknik Dergisi 20 (2017 ): 993-1001 <
Chicago Aydın, İ. , Engin, F. "Hydroxyapatite Coating on Ti6Al4V Alloy Surface Through Biomimetic Method Using Glycolic Acid - Sodium Gluconate Buffer System and Examination of Properties of the Coating". Politeknik Dergisi 20 (2017 ): 993-1001
RIS TY - JOUR T1 - Hydroxyapatite Coating on Ti6Al4V Alloy Surface Through Biomimetic Method Using Glycolic Acid - Sodium Gluconate Buffer System and Examination of Properties of the Coating AU - İbrahim Aydın , Ferdi Engin Y1 - 2017 PY - 2017 N1 - doi: 10.2339/politeknik.369141 DO - 10.2339/politeknik.369141 T2 - Politeknik Dergisi JF - Journal JO - JOR SP - 993 EP - 1001 VL - 20 IS - 4 SN - -2147-9429 M3 - doi: 10.2339/politeknik.369141 UR - Y2 - 2022 ER -
EndNote %0 Politeknik Dergisi Hydroxyapatite Coating on Ti6Al4V Alloy Surface Through Biomimetic Method Using Glycolic Acid - Sodium Gluconate Buffer System and Examination of Properties of the Coating %A İbrahim Aydın , Ferdi Engin %T Hydroxyapatite Coating on Ti6Al4V Alloy Surface Through Biomimetic Method Using Glycolic Acid - Sodium Gluconate Buffer System and Examination of Properties of the Coating %D 2017 %J Politeknik Dergisi %P -2147-9429 %V 20 %N 4 %R doi: 10.2339/politeknik.369141 %U 10.2339/politeknik.369141
ISNAD Aydın, İbrahim , Engin, Ferdi . "Hydroxyapatite Coating on Ti6Al4V Alloy Surface Through Biomimetic Method Using Glycolic Acid - Sodium Gluconate Buffer System and Examination of Properties of the Coating". Politeknik Dergisi 20 / 4 (Aralık 2017): 993-1001 .
AMA Aydın İ. , Engin F. Hydroxyapatite Coating on Ti6Al4V Alloy Surface Through Biomimetic Method Using Glycolic Acid - Sodium Gluconate Buffer System and Examination of Properties of the Coating. Politeknik Dergisi. 2017; 20(4): 993-1001.
Vancouver Aydın İ. , Engin F. Hydroxyapatite Coating on Ti6Al4V Alloy Surface Through Biomimetic Method Using Glycolic Acid - Sodium Gluconate Buffer System and Examination of Properties of the Coating. Politeknik Dergisi. 2017; 20(4): 993-1001.
IEEE İ. Aydın ve F. Engin , "Hydroxyapatite Coating on Ti6Al4V Alloy Surface Through Biomimetic Method Using Glycolic Acid - Sodium Gluconate Buffer System and Examination of Properties of the Coating", Politeknik Dergisi, c. 20, sayı. 4, ss. 993-1001, Ara. 2017, doi:10.2339/politeknik.369141
Politeknik Dergisi
  • ISSN: 1302-0900
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1998

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