Metabolic Characteristics and Diagnostic Contribution of 18F-FDG PET/CT in Gastric Carcinomas

Objectives: The aim of this study was to evaluate 18F-fluoro-2-deoxy-glucose (FDG) uptake patterns in primary tumors and metastatic lesions, and also to assess the diagnostic contribution of positron emission tomography/computed tomography (PET/CT) in the initial staging of gastric cancer (GC).Methods: The total number of 341 patients with GC were included in this study. All 18F-FDG PET/CT imagings were performed for initial staging. The maximum standardized uptake value (SUVmax) of primary tumor, obtained from 18F-FDG PET/CT imaging was compared between subtypes of GC.Results: Mean SUVmax of 339 patients’ primary tumor was 12.9±8.6. The highest mean SUVmax was detected in patients with medullary subtype GC (17.8±9.9) while the lowest mean SUVmax (9.7±7.6) was seen in signet ring cell carcinoma (SRCC). The primary mean SUVmax was found statistically higher in adenocarcinoma (AC) group than SRCC group (p3 cm) in patients with AC (p=0.03). Primary tumor SUVmax was found statistically higher in regional lymph node (RLN) positive patients than in RLN negative patients in AC and SRCC groups (p

Mide Kanserinin Metabolik Özellikleri ve 18F-FDG PET/BT’nin Tanısal Katkısı

Amaç: Bu çalışmanın amacı primer tümörlerde ve metastatik lezyonlarda 18F-floro-2-deoksi-glukoz (18F-FDG) tutulum paternlerini değerlendirmek ve ayrıca mide kanserinin (MK) evrelemesinde pozitron emisyon tomografi/bilgisayarlı tomografi’nin (PET/BT) tanısal katkısını değerlendirmektir.Yöntem: Çalışmaya toplam 341 MK hastası dahil edildi. Primer evreleme 18F-FDG PET/BT görüntüleme ile yapıldı. 18F-FDG PET/BT görüntülemeden elde edilen primer tümöre ait maksimum standart tutulum (SUVmax) MK alt tipleri arasında karşılaştırıldı.Bulgular: Üç yüz otuz dokuz hastaya ait primer tümörün ortalama SUVmax değeri 12,9±8,6 idi. En yüksek ortalama SUVmax, medüller alt tip MK’li hastalarda (17,8±9,9), en düşük ortalama SUVmax (9,7±7,6), taşlı yüzük hücreli mide kanserinde (TYHMK) görüldü. Ortalama SUVmax, adenokarsinom (AK) grubunda TYHMK grubundan istatistiksel olarak daha yüksek bulundu (p3 cm) ile istatistiksel olarak anlamlı derecede ilişkili bulundu (p=0,03). Primer tümör SUVmax, bölgesel lenf nodu (RLN) pozitif olan hastalarda AK ve TYHMK gruplarındaki RLN negatiflerden anlamlı olarak yüksek bulundu (p

Kaynakça

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Kaynak Göster

Molecular Imaging and Radionuclide Therapy
  • ISSN: 2146-1414
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1992

1.3b474

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