Oktay SARI, Alpaslan TANOĞLU, Onur MAHMUTOGLU, ÜMİT AYDOĞAN, FATMA BEYAZİT, Yaşam Kemal AKPAK, Uğur KESKİN

Effect of Subclinical Hypothyroidism on the Mean Platelet Volume of Pregnant Women

Subclinical hypothyroidism (SH) is a frequently seen clinical disorder, which needs to be managed strictly in the pregnant population. SH is closely related with newborn complications and also suggested to be risk factor for cardiovascular events. Mean platelet volume (MPV), a determinant of platelet function, is a newly emerging risk marker for cardiovascular events. The aim of this study was to evaluate how MPV values and other hematological parameters are influenced in pregnants with subclinical hypothyroidism. A total of 70 subclinical hypothyroidic pregnants and 40 euthyroid pregnant controls were enrolled in our study. Age, body mass index (BMI), erythrocyte and platelet parameters were all evaluated. Erytocyte parameters and thrombocyte parameters, including MPV, were not statistically significantly different between pregnants with SH and healthy pregnants (p>0.05). Mean free T3 and TSH levels of subclinical hypothyroidic pregnants were statistically significantly different from healthy pregnant (p=0.04 and p

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1. Casey BM, Dashe JS, Wells CE, McIntire DD, Byrd W, Leveno KJ, Cunningham FG.. Subclinical hypothyroidism and pregnancy outcomes. Obstet Gynecol. 2005;105(2):239-45.

2. Jacob JJ. Subclinical hypothyroidism in the first trimester of pregnancy in North India. Indian J Endocrinol Metab. 2013; 17(1):160-1.

3. Nelson DB, Casey BM, McIntire DD, Cunningham FG. Subsequent pregnancy outcomes in women previously diagnosed with subclinical hypothyroidism. Am J Perinatol. 2014; 31(1):77-84.

4. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000;160(4):526-34.

5. Leung AS, Millar LK, Koonings PP, Montoro M, Mestman JH. Perinatal outcome in hypothyroid pregnancies. Obstet Gynecol. 1993;81(3):349-53.

6. Casey BM, Dashe JS, Spong CY, McIntire DD, Leveno KJ, Cunningham GF. Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy. Obstet Gynecol. 2007; 109(5):1129-35.

7. Sari O, Tanoglu A, Aydogan U, Simsek A, Serdar AM, Akbulut H, Kurtulus O, Saglam K. Serum visfatin levels before and after levothyroxin treatment in cases with hypothyroidism and subclinical hypothyroidism and their relationships between the lipid levels. Biomedical Research. 2012;23(1):55-9.

8. Duntas LH. Thyroid disease and lipids. Thyroid. 2002;12(4):287-93.

9. Torun AN, Uzum AK, Aksoy N. Overt and mild subclinical hypothyroidism do not ınfluence mean platelet volume in premenopausal women having low cardiac risk. Clin Appl Thromb Hemost. 2012;18(3):312-5.

10. Van der Loo B, Martin JF. Megakaryocytes and platelets in vascular disease. Baillieres Clin Haematol. 1997;10(1):109-23.

11. Halbmayer WM, Haushofer A, Radek J, Schön R, Deutsch M, Fischer M. Platelet size, fibrinogen and lipoprotein (a) in coronary heart disease. Coron Artery Dis. 1995;6(5):397-402.

12. Yilmaz H, Ertugrul O, Ertugrul B, Ertugrul D. Mean platelet volume in patients with subclinical hypothyroidism. Platelets. 2011;22(2):143-7.

13. Erikci AA, Karagoz B, Ozturk A, Caglayan S, Ozisik G, Kaygusuz I, Ozata M. The effect of subclinical hypothyroidism on platelet parameters. Hematology. 2009;14(2):115-7.

14. Coban E, Yazicioglu G, Ozdogan M. Platelet activation in subjects with subclinical hypothyroidism. Med Sci Monit. 2007; 13(4):211-4.

15. Juan P, Stefano G, Antonella S, Albana C. Platelets in pregnancy. J Prenat Med. 2011;5(4):90-2.

16. Ahmed Y, van Iddekinge B, Paul C, Sullivan HF, Elder MG. Retrospective analysis of platelet numbers and volumes in normal pregnancy and preeclampsia. Br J Obstet Gynaecol. 1993;100(3):216-20.

17. Valera MC, Parant O, Vayssiere C, Arnal JF, Payrastre B. Physiologic and pathologic changes of platelets in pregnancy. Platelets. 2010; 21(8):587-95.

18. Gioia S, Piazze J, Anceschi MM, Cerekja A, Alberini A, Giancotti A, Larciprete G, Cosmi EV. Mean platelet volume: association with adverse neonatal outcome. Platelets. 2007;18(4):284-8.

19. Park Y, Schoene N, Harris W. Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets. 2002;13(5-6):301-6. 20. Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract. 2009;63(10):1509-15.