Can bevacizumab administered together with beta radiation in treatment of pterygium play a role in additive effect and/or treatment of the side effects?

Pterygium is one of corneal-conjunctival pathologies that are frequently encountered by ophthalmologists. Its etiology, pathogenesis and treatment have been caused controversy for many years and remain as a problem, which is yet to be fully enlightened. The main treatment of pterygium is surgery. The most crucial postoperative problem is recurrence of the disease. Surgical methods have been sought for years to minimize recurrence with complementary treatment have been added to these methods including conjunctival autografting, bevacizumab and β-irradiation. No study was found to investigate additive use of bevacizumab and beta-radiation in postop or recurrent pterygium. Further phase 1 and phase 2 trials are needed to investigate the effectiveness of additive use of bevacizumab and beta-radiation in treatment of pterygium.

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Hacıoğlu D, Erdöl H. Developments and current approaches in the treatment of pterygium. Int Ophthalmol. 2016 Sep 23 [Epub ahead of print]

Ali AM, Thariat J, Bensadoun RJ, et al. The role of radiotherapy in the treatment of pterygium: A review of the literature including more than 6000 treated lesions. Cancer Radiother. 2011;15:140-7.

Vastardis I, Pajic B, Greiner RH, et al. Prospective study of exclusive strontium-/yttrium-90 beta-irradiation of primary and recurrent pterygia with no prior surgical excision. Clinical outcome of long-term follow-up. Strahlenther Onkol. 2009 Dec;185:808-14.

Viani GA, De Fendi LI, Fonseca EC, et al. Low or high fractionation dose β-radiotherapy for pterygium? A randomized clinical trial. Int J Radiat Oncol Biol Phys. 2012;82:e181-5.

Mak RK, Chan TC, Marcet MM, et al. Use of anti-vascular endothelial growth factor in the management of pterygium. Acta Ophthalmol. 2016 Jul 30. [Epub ahead of print] Review.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
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