SÜMEYRA NERGİZ AVCIOĞLU, SELDA DEMİRCAN SEZER, SÜNDÜZ ÖZLEM ALTINKAYA, MERT KÜÇÜK, İMRAN KURT ÖMÜRLÜ, HASAN YÜKSEL

Erythrocyte Indices in Patients with Preeclampsia

Amaç: Bu çalışmanın amacı preeklampsi tanısı konmuş hastalarda eritrosit indekslerini araştırmaktır. Gereç ve Yöntemler: Bu çalışmaya 102 preeklampsi (49 hafif ve 53 şiddetli preeklampsi olmak üzere) ve 98 kontrol hastası dahil edilmiştir. Tüm çalışma grubunda eritrosit indeksleri olan ortalama korpuskular hacim (MCV), ortalama korpuskular hemoglobin (MCH), ortalama korpuskular hemoglobin konsantrasyonu (MCHC), eritrosit sayımı ve eritrosit dağılım genişliği değerleri otomatik kan sayım cihazı ile ölçüldü Bulgular: Preeklampsi grubunda, medyan RDW %15 (13,8-16,57), ortalama MCV değeri 80,42±7,86 (fL), ortalama MCHC değeri 33,66±1,71 (g/dL) ve kontrol grubunda medyan RDW %13,9 (13-15,6), ortalama MCV değeri 83,88±2,31 (fL), ortalama MCHC değeri 33,09±1,48 (g/dL) idi (sırasıyla p0,05). Preeklampsi grubunda subgroup analizi yapıldığında, hafif preeklampsi grubuna göre, ciddi preeklampsi grubunda artmış RDW değerleri (% 15,4 (13,9-17,45) vs %14,3 (13,7-15,7), p=0,031), azalmış MCV değerleri (78,81±7,91 (fL) vs 82,16±7,43 (fL), p=0,03), artmış RBC değerleri (4,16 (3,79-4,85)x(1012/L) vs 3,82 (3,45-4,34)x(1012/L), (p=0,006) saptandı. Preeklampsi ve kontrol grubu hastalarının Receiver operatör karakteristik (ROK) analizi sonuçlarına göre eritrosit sayımı ve eritrosit dağılım genişliğinin hastalığı tespit etmede yüksek prediktif değerleri saptandı (p

Preeklamptik Hastalarda Eritrosit İndeksleri

Objective: The purpose of study was to investigate erythrocyte indices in patients with preeclampsia. Materials and Methods: The study population consisted of 102 patients with preeclampsia (49 mild, 53 severe preeclampsia) and 98 control pregnant patients. For the entire study population, red blood cell indices, including baseline mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), and red blood cell (RBC) were measured by using an automatic blood counter.Results: In the preeclampsia group, the median RDW was 15% (13.8-16.57), whereas in the control group it was 13.9% (13-15.6) (p<0.01). On the other hand, the mean MCV value was 80.42±7.86 (fL) in preeclampsia group and 83.88±2.31 (fL) in control group (p=0.003). Besides, the mean MCHC value was 33.66±1.71 (g/dL) in preeclampsia group and 33.09±1.48 (g/dL) in control group (p=0.012). However MCH and RBC values were not statistically different between the groups. (p>0.05) Moreover, subgroup analysis revealed that RDW levels were significantly increased in preeclampsia subjects than in mild preeclampsia patients (15.4% (13.9-17.45) vs 14.3% (13.7-15.7), p=0.031), MCV levels were decreased (78.81±7.91 (fL) vs 82.16± 7.43 (fL), p=0.03), RBC values were increased (4.16 (3.79-4.85)x(1012/L) vs 3.82 (3.454.34)x(1012/L), (p=0.006)) in patients with severe preeclampsia when compared to the patients with mild preeclampsia. In the receiver operator characteristic (ROC) analysis of subjects with and without preeclampsia, RDW and MCV showed high predictive values (p<0.01). Besides, in ROC analysis of preeclampsia patients with different severities, RDW and RBC showed the ideal predictive values (p=0.006, p=0.031, respectively).Conclusion: Our study results revealed that among the red blood cell indices, only increased RDW values were associated with both the presence and the severity of preeclampsia.

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