Aysun YAKUT, Ahmet Numan DEMİR, Gülbüz SEZGİN, Ersan EMRE, Refik DEMİRTUNÇ

YÜKSEK DOZDA METOTREKSAT KULLANIMINA BAĞLI GELİŞEN PANSİTOPENİ VE STOMATİT

Romatoid artrit RA , sinoviyal hücre proliferasyonu ve inflamasyonunun eklemde destrüksiyon yapması ile karakterize, idiyopatik, kronik, ilerleyici, otoimmün, sistemik ve inflamatuar bir hastalıktır. Hastalığın progresyonunu engellemek amacıyla hastalığı modifiye edici ilaçlar kullanılmaktadır. Bu grup ilaçlar içinde, öncelikli ilk tercih ilaç metotreksattır MTX . Bu yazıda, RA tanısı ile MTX tedavisi başlanıp, yüksek doz MTX alan, bunun sonucunda stomatit ve pansitopeni gelişen olgu sunulmak istenirken, ilacı düzenli ve uygun şekilde alamayacak, aynı zamanda da düzenli takiplere gelemeyecek hastalarda MTX yerine farklı modifiye edici ajanlar tercih edilmesi gerekliliği vurgulanmak istenmiştir.

Anahtar Kelimeler:

metotreksat, pansitopeni, stomatit, romatoid artrit

PANCYTOPENIA AND STOMATITIS INDUCED BY HIGH DOSE METHOTREXATE USE: CASE REPORT

Rheumatoid arthritis is a chronic idiopathic progressive autoimmune systemic inflammatory disease characterized by destructive effects of synovial cell proliferation and inflammation on the joints. In order to prevent its progression, disease modifying drugs are used. Among these, Methotrexate MTX is the drug of choice. The initial aim of the report is to present a patient with RA who developed stomatitis and pancytopenia under high dose MTX whereas the second aim is to emphasize the importance of choosing different modifying agents instead of MTX in patients who are not compliant with follow-up visits.

Keywords:

methotrexate, pancytopenia, stomatitis, rheumatoid arthritis,

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