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• Ogawa K, Hirai M, Katsube T, et al. Suppres- sion of cellular immunity by surgical stress. Surgery 2000;127(3):329-336.
• Leaver HA, Craig SR, Yap PL, Walker WS. Lym- phocyte responses following open and mini- mally invasive thoracic surgery. Eur J Clin Invest 2000;30(3):230-238.
• Toft P, Lillevang ST, Tİnnesen E, Svendsen P, Ho¨hndorf K. Redistribution of lymphocytes following E. coli sepsis. Scand J Immunol 1993;38(6):541-545.
• Cristaldi M, Rovati M, Elli M, Gerlinzani S, Les- ma A, Balzarotti L, et al. Lymphocytic subpop- ulation changes after open and laparoscopic cholecystectomy: a prospective and compar- ative study on 38 patients. Surg Laparosc Endosc 1997;7(3):255-261.
• Wichmann MW, Hüttl TP, Winter H, et al. Immunological effects of laparoscopic vs open colorectal surgery: a prospective clinical study. Arch Surg 2005;140(7):692-697.
• Kawasaki T, Ogata M, Kawasaki C, Okamoto K, Sata T. Effects of epidural anaesthesia on surgical stress-induced immunosuppression during upper abdominal surgery. Br J Anaesth 2007;98(2):196-203.
• Synder GL, Greenkey S.Effect of anaesthetic technique and other perioperative factors on cancer recurrence. Br J Anaesth 2010; 105 (2): 106-115.
• Wu GJ, Tai YT, Chen TL, Lin LL, Ueng YF, Chen RM. Propofol specifically inhibits mitochondrial membrane potential but not complex I NADH dehydrogenase activity, thus reducing cellular ATP biosynthesis and migration of macrophag- es. Ann N Y Acad Sci 2005;1042:168-176.
• Chen RM, Wu CH, Chang HC, Wu GJ, Lin YL, Sheu JR. Propofol suppresses macrophage functions and modulates mitochondrial membrane potential and cellular adenosine triphosphate synthesis. Anesthesiology 2003; 98(5):1178-1185.
• Brune IB, Wilke W, Hensler T, Feussner H, Holz- mann B, Siewert JR. Normal T lymphocyte and monocyte function after minimally invasive surgery. Surg Endosc 1998;12(8): 1020-1024.
• Kennedy BC, Hall GM. Neuroendocrine and inflammatory aspects of surgery: do they affect outcome? Acta Anaesthesiol Belg 1999;50(4):205-209
• Larsson EL. Cyclosporin A and dexamethasone suppress T cell responses by selectively acting at distinct sites of the triggering process. J Immunol 1980;124(6):2828-2833.
• Arya SK, Wong-Staal F, Gallo RC. Dexameth- asone-mediated inhibition of human T cell growth factor and gammainterferon messen- ger RNA. J Immunol 1984;133(1):273-276.
• Nieto MA,Gonza´lez A, Gambo´nF,Dı´az-Espa- da F, Lo´pez-Rivas A. Apoptosis in human thy- mocytes after treatment with glucocorticoids. Clin Exp Immunol 1992;88(2):341-344.
• Sallenave JM, Shulmann J, Crossley J, Jordana M, Gauldie J. Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes. Am J Respir Cell Mol Biol 1994;11(6):733-741.
• Mulligan MS, Lentsch AB, Huber-Lang M, Guo RF, Sarma V, Wright CD. Anti-inflammatory effects of mutant forms of secretory leuko- cyte protease inhibitor. Am J Pathol 2000;156 (3):1033-1039.
• Mozo L, Gayo A, Sua´ rez A, Rivas D, Zamora- no J, Gutie´rrez C. Glucocorticoids inhibit IL-4 and mitogen-induced IL-4R alpha chain expres- sion by different posttranscriptional mecha- nisms. J Allergy Clin Immunol 1998;102 (6 Pt 1):968-976.
• de Coupade C, Gear RW, Dazin PF, Sroussi HY, Green PG, Levine JD. Beta 2-adrenergic recep- tor regulation of human neutrophil function is sexually dimorphic. Br J Pharmacol 2004; 143(8):1033-1041.
• Tamir A, Isakov N. Cyclic AMP inhibits phos- phatidylinositol coupled and uncoupled mito- genic signals in T lymphocytes. Evidence that cAMP alters PKC-induced transcription regula- tion of members of the jun and fos family of genes.J Immunol 1994;152(7):3391-3399.
• Bloemen PG, van den Tweel MC, Henricks PA, et al. Increased cAMP levels in stimulated neu- trophils inhibit their adhesion to human bron- chial epithelial cells. Am J Physiol 1997;272(4 Pt 1):L580-587.
• Kitamura T, Ohno N, Bougaki M, Ogawa M, Yamada Y. Comparison of the effects of sevo- flurane and propofol on changes in leuko- cyte-count induced by surgical stress. Masui 2008;57(8):968-972.
• Le Cras AE, Galley HF, Webster NR. Spinal but not general anesthesia increases the ratio of T helper 1 to T helper 2 cell subsets in patients undergoing transurethral resection of the prostate. Anesth Analg 1998;87(6):1421-1425.
• Fuchs BA, Pruett SB. Morphine induces apop- tosis in murine thymocytes in vivo but not in vitro: involvement of both opiate and glu- cocorticoid receptors. J Pharmacol Exp Ther 1993; 266(1):417-423.
• Graham EA. The influence of ether and ether anaesthesia on bacteriolysis, agglutination, and phagocytosis. J Infect Dis 1911;8:147-175.
• Tartter PI, Steinberg B, Barron DM, Martinelli G. The prognostic significance of natural killer cytotoxicity in patients with colorectal cancer. Arch Surg 1987;122(11):1264-1268.
• Levy SM, Herberman RB, Maluish AM, Schlien B, Lippman M. Prognostic risk assessment in primary breast cancer by behavioral and immunological parameters. Health Psychol 1985;4(2):99-113.
• Fujisawa T, Yamaguchi Y. Autologous tumor killing activity as a prognostic factor in primary resected nonsmall cell carcinoma of the lung. Cancer 1997;79(3):474-481.
• Wakefield CH, Carey PD, Foulds S, Monson JR, Guillou PJ. Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery. Br J Surg 1993;80(2):205-209.
• Ahlers O, Nachtigall I, Lenze J, Goldmann A, Schulte E, Ho¨hne C, et al. Intraoperative tho- racic epidural anaesthesia attenuates stress-in- duced immunosuppression in patients under- going major abdominal surgery. Br J Anaesth 2008;101 (6):781-787.
• Page GG, Blakely WP, Ben-Eliyahu S. Evidence that postoperative pain is a mediator of the tumor-promoting effects of surgery in rats. Pain 2001;90(1-2):191-199.
• Mahdy AM, Galley HF, Abdel-Wahed MA, el-Korny KF, Sheta SA, Webster NR. Differential modulation of interleukin- 6 and interleukin-10 by diclofenac in patients undergoing major surgery. Br J Anaesth 2002;88(6):797-802.
• Kendall SJ, Weir J, Aspinall R, Henderson D, Rosson J. Erythrocyte transfusion causes im- munosuppression after total hip replacement. Clin Orthop Relat Res 2000;(381):145-155.
• Wang G, Jiang Z, Zhao K, Li G, Liu F, Pan H, Li J. Immunologic response after laparoscopic colon cancer operation within an enhanced recovery program.J Gastrointest Surg 2012; 16(7): 1379-1388.
• Bobocea AC, Trandafir B, Bolca C, Cordoş I. Minimally invasive surgery in cancer. Immu- nological response.Chirurgia 2012; 107(2): 154-157.
• Smyth MJ, Taniguchi M, Street SE. The anti-tu- mor activity of IL-12: mechanisms of innate immunity that are model and dose dependent. J Immunol 2000;165(5):2665-2670.
• Kobayashi T, Shiiba K, Satoh M, et al. Inter- leukin-12 administration is more effective for preventing metastasis than for inhibiting primary established tumors in a murine model of spontaneous hepatic metastasis. Surg Today 2002;32(3):236-242.
• Schwartz Y, Avraham R, Benish M, Rosenne E, Ben-Eliyahu S. Prophylactic IL-12 treatment reduces postoperative metastasis: mediation by increased numbers but not cytotoxicity of NK cells. Breast Cancer Res Treat 2008;107(2): 211-223.
• Caprotti R, Brivio F, Fumagalli L, et al. Free-from-progression period and overall short preoperative immunotherapy with IL-2 increas- es the survival of pancreatic cancer patients treated with macroscopically radical surgery. Anticancer Res 2008;28(3B):1951-1954.
• Hsueh EC, Essner R, Foshag LJ, et al. Prolonged survival after complete resection of dissemi- nated melanoma and active immunotherapy with a therapeutic cancer vaccine. J Clin Oncol 2002;20(23): 4549-4554.