Chemical Content and Biological Activity Spectrum of Nigella sativa Seed Oil

In this study, it was aimed to investigate the chemical compositionand biological activities including antioxidant, anticholinesterase,antimicrobial and urease activity of Nigella sativa seed oil growing inMuğla (Köyceğiz). The oil of plant was obtained using Soxhletapparatus. Thirty-one components of the oil were determined by GasChromatography-Mass Spectrometry (GC-MS). The majorcomponents of oil were detected as palmitic acid (10.48%), linoleic acid(8.05%), o-cyemene (7.11%), 3,5-dimethyl cyclohexanol (6.68%),thymoquinone (6.44%), p-tert-buthyl catechol (6.28%) and 8-methyl-1-undecene (3.28%). The findings obtained from biological activityassays showed that Nigella sativa oil was a promising candidate thatcan be used in the discovery of new drugs and the preparation of newnatural drug preparations.

Çörek Otu Tohumu Yağının Kimyasal İçeriği ve Biyolojik Aktivite Spektrumu

Bu çalışmada, Muğla (Köyceğiz)'de yetişen Nigella sativa (çörek otu) tohumu yağının kimyasal bileşimi ile yağın antioksidan, antikolinesteraz, antimikrobiyal ve üreaz aktivitesinin araştırılması amaçlanmıştır. Bitkinin yağı, Soxhlet aparatı kullanılarak elde edildi. Yağ bileşimi Gaz Kromatografisi-Kütle Spektrometresi (GC-MS) ile belirlendi. GC-MS sonuçlarından, yağın otuz bir bileşeni tespit edilebildi. Yağın ana bileşenleri palmitik asit (% 10.48), linoleik asit (%8.05), o-siemen (% 7.11), 3,5-dimetil sikloheksanol (% 6.68), timokinon (% 6.44), p-tert-butil katekol (% 6.28) ve 8-metil-1-undesen (% 3.28) olarak belirlendi. Biyolojik aktivite test sonuçları tıbbi özelliği olan çörek otu yağının yeni ilaçların keşfinde ve yeni doğal drog preparatların hazırlanmasında kullanılabilecek umut verici bir aday olduğunu göstermektedir.

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