SEYİT ANKARALI, ERSİN BEYAZÇİÇEK, ERKAN KILINÇ, ÖZGE BEYAZÇİÇEK, Kayhan ÖZKAN, AYHAN ÇETİNKAYA, ŞENGÜL CANGÜR, HANDAN ANKARALI

Gül Yağının Sıçanlarda Penisilin İle Tetiklenen Epileptiform Aktivite Üzerine Etkileri: Elektrofizyolojik Bir Çalışma

Amaç: Gül yağı analjezik, antispazmodik, antioksidan ve nöroprotektif etkilere sahiptir. Anti-epileptik etki üzerine yapılan çalışmalar ise yetersizdir. Sunulan çalışmada, gül yağının sıçanlarda penisilin ile tetiklenen epilepsi modelinde epileptiform aktivite üzerine akut etkilerinin araştırılması amaçlanmıştır.Gereç ve Yöntem: 230-260 gr ağırlığında kırk iki erkek wistar sıçan her grupta yedi olmak üzere altı gruba ayrıldı. Gruplar kontrol (penisilin), yalnız gül yağı, diazepam ve gül yağının 100, 500 ve 1000 mg/kg olmak üzere farklı dozlarından oluşmaktadır. Sıçanlara penisilin uygulamasından 30 dakika önce gül yağının farklı dozları uygulandı. Penisilin uygulamasından sonra 2 saat boyunca her bir hayvandan elektrokortikogram kayıtları alındı.Bulgular: Gül yağının sadece 100 mg/kg dozu epileptiform aktivitenin epileptik diken-dalga frekansını önemli derecede azalttı. Bununla birlikte epileptiform aktivite latens ve diken-dalga amplitüdü açısından karşılaştırıldığında gruplar arasında anlamlı bir fark yoktu.Sonuç: Gül yağının akut olarak uygulanması sıçanlarda, penisilin ile tetiklenen epileptiform aktivitenin diken-dalga frekansını azaltmaktadır. Böylece bulgularımız gül yağının anti-epileptik etkilere sahip olduğunu göstermektedir.

Anahtar Kelimeler:

Gül Yağı, Epileptiform Aktivite, Epilepsi, Elektrokortikogram

The Effect of Rose Oil on Penicillin-Induced Epileptiform Activity in Rats: An Electrophysiological Study

Objective: Rose oil (from Rosa damascene) has several effects which are analgesic, antispasmodic, antioxidant and neuroprotective role. Its antiepileptic effect has not been yet studied enough. In the present study, it was aimed to investigate acute effects of rose oil on the epileptiform activity in penicillin-induced epilepsy model in rats.Methods: Forty-two male Wistar rats weighing 230 to 260 g were divided into six groups with seven rats in each group. Control (+Penicillin), RO alone, Diazepam, and different doses of Rose oil including 100, 500 and 1000 mg/kg. Rats were pretreated with different doses of RO 30 min prior to penicillin treatment. Electrocorticogram recordings were taken from each animal for 2 hours after penicillin treatment.Results: Only the dose of 100 mg/kg of rose oil reduced significantly epileptic spike-wave frequency of epileptiform activity. However, comparing in terms of latency and spike-wave amplitude of epileptiform activity, there were no significant difference between the groups.Conclusions: In conclusion, acute administration of rose oil reduces spike-wave frequency of penicillin-induced epileptiform activity in rats. Therefore, these findings indicate that rose oil has antiepileptic effects.

Keywords:

Rose oil, Epileptiform activity, Epilepsy, Electrocorticography,

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ISSN: 1309-3878
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 2009
Yayıncı: Düzce Üniversitesi Tıp Fakültesi Aile Hekimliği AD adına Yrd.Doç.Dr.Cemil Işık Sönmez