Gülten Emek TUNA, Gamze Sevri EKREN AŞICI, Pınar Alkım ULUTAŞ

Ehrlichiosis ile Doğal Enfekte Köpeklerde Serum C-Reaktive Protein, Prokalsitonin ve Seruloplazmin konsantrasyonları

Bu çalışma, Ehrlichiosis ile doğal enfekte köpeklerde inflamatuar sürecin potansiyel biyokimyasal belirteçlerinden olan C-reaktif protein (CRP), Prokalsitonin (PCT) ve seruloplazmin (Cp) konsantrasyonlarını değerlendirmeyi amaçladı. Çalışmaya, klinik olarak sağlıklı 8 (Sağlıklı grup) ve Ehrlichia spp. ile mono enfekte 12 (Ehrlichia grubu) olmak üzere toplam 20 köpek dahil edildi. Ehrlichia grubundaki köpekler, klinik olarak aktif enfeksiyon belirtileri gösteren köpekler arasından seçildi ve hastalıkları, ticari test kitleri ile teşhis edildi. Serum CRP ve PCT seviyeleri köpek spesifik ticari ELISA test kitleri ile analiz edildi ve Cp konsantrasyonu kolorimetrik yöntemle belirlendi. Ehrlichia grubundaki CRP konsantrasyonu, sağlıklı grupla karşılaştırıldığında anlamlı olarak daha yüksekti. Serum PCT ve Cp konsantrasyonlarında gruplar arasında anlamlı fark yoktu. Sonuç olarak, serum CRP konsantrasyonundaki artış, Ehrlichiosis'li köpeklerde inflamatuar süreçlerin saptanmasında kullanılabilir. Ek olarak bu çalışma, PCT ve Cp konsantrasyonlarının Ehrlichiosis'li köpeklerde inflamatuar durumu belirlemek için klinik olarak yararlı belirteçler olmadığını göstermiştir.

Anahtar Kelimeler:

C-reaktif protein, Ehrlichiosis, köpek, prokalsitonin, seruloplazmin

Serum C-Reactive Protein, Procalcitonin and Ceruloplasmin Concentrations in Dogs with Naturally İnfected Ehrlichiosis

This study aimed to evaluate the concentrations of C-reactive protein (CRP), Procalcitonin (PCT), and ceruloplasmin (Cp), which are potential biochemical markers of the inflammatory process in dogs naturally infected with Ehrlichiosis. A total of 20 dogs, 8 clinically healthy (Healthy group) and 12 mono-infected with Ehrlichia spp. (Ehrlichia group) were included in the study. Dogs in the Ehrlichia group were selected from those showing clinical signs of active infection, and their diseases were diagnosed with commercial test kits. Serum CRP and PCT levels were analysed by commercially available test kits, and Cp concentration was determined by colourimetric methods. The CRP concentration in the Ehrlichia group was significantly higher compared to the healthy group. There was no significant difference between the groups in serum PCT and Cp concentrations. As a result, the increase in serum CRP concentration can be used for detecting inflammatory processes in dogs with Ehrlichiosis. In addition, this study showed that PCT and Cp concentrations are not clinically useful markers for determining inflammatory status in dogs with Ehrlichiosis.

Keywords:

C-reactive protein, ceruloplasmin, dog, Ehrlichiosis, procalcitonin,

Tam Metin

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Bibtex	@araştırma makalesi { kvj1238703, journal = {Kocatepe Veterinary Journal}, issn = {1308-1594}, eissn = {2147-6853}, address = {}, publisher = {Afyon Kocatepe Üniversitesi}, year = {2023}, volume = {16}, number = {2}, pages = {174 - 181}, doi = {10.30607/kvj.1238703}, title = {Serum C-Reactive Protein, Procalcitonin and Ceruloplasmin Concentrations in Dogs with Naturally İnfected Ehrlichiosis}, key = {cite}, author = {Tuna, Gülten Emek and Ekren Aşıcı, Gamze Sevri and Ulutaş, Pınar Alkım} }
APA	Tuna, G. E. , Ekren Aşıcı, G. S. & Ulutaş, P. A. (2023). Serum C-Reactive Protein, Procalcitonin and Ceruloplasmin Concentrations in Dogs with Naturally İnfected Ehrlichiosis . Kocatepe Veterinary Journal , 16 (2) , 174-181 . DOI: 10.30607/kvj.1238703
MLA	Tuna, G. E. , Ekren Aşıcı, G. S. , Ulutaş, P. A. "Serum C-Reactive Protein, Procalcitonin and Ceruloplasmin Concentrations in Dogs with Naturally İnfected Ehrlichiosis" . Kocatepe Veterinary Journal 16 (2023 ): 174-181 <
Chicago	Tuna, G. E. , Ekren Aşıcı, G. S. , Ulutaş, P. A. "Serum C-Reactive Protein, Procalcitonin and Ceruloplasmin Concentrations in Dogs with Naturally İnfected Ehrlichiosis". Kocatepe Veterinary Journal 16 (2023 ): 174-181
RIS	TY - JOUR T1 - Ehrlichiosis ile Doğal Enfekte Köpeklerde Serum C-Reaktive Protein, Prokalsitonin ve Seruloplazmin konsantrasyonları AU - Gülten EmekTuna, Gamze SevriEkren Aşıcı, Pınar AlkımUlutaş Y1 - 2023 PY - 2023 N1 - doi: 10.30607/kvj.1238703 DO - 10.30607/kvj.1238703 T2 - Kocatepe Veterinary Journal JF - Journal JO - JOR SP - 174 EP - 181 VL - 16 IS - 2 SN - 1308-1594-2147-6853 M3 - doi: 10.30607/kvj.1238703 UR - Y2 - 2023 ER -
EndNote	%0 Kocatepe Veteriner Dergisi Serum C-Reactive Protein, Procalcitonin and Ceruloplasmin Concentrations in Dogs with Naturally İnfected Ehrlichiosis %A Gülten Emek Tuna , Gamze Sevri Ekren Aşıcı , Pınar Alkım Ulutaş %T Serum C-Reactive Protein, Procalcitonin and Ceruloplasmin Concentrations in Dogs with Naturally İnfected Ehrlichiosis %D 2023 %J Kocatepe Veterinary Journal %P 1308-1594-2147-6853 %V 16 %N 2 %R doi: 10.30607/kvj.1238703 %U 10.30607/kvj.1238703
ISNAD	Tuna, Gülten Emek , Ekren Aşıcı, Gamze Sevri , Ulutaş, Pınar Alkım . "Serum C-Reactive Protein, Procalcitonin and Ceruloplasmin Concentrations in Dogs with Naturally İnfected Ehrlichiosis". Kocatepe Veterinary Journal 16 / 2 (Haziran 2023): 174-181 .
AMA	Tuna G. E. , Ekren Aşıcı G. S. , Ulutaş P. A. Serum C-Reactive Protein, Procalcitonin and Ceruloplasmin Concentrations in Dogs with Naturally İnfected Ehrlichiosis. Kocatepe Veterinary Journal. 2023; 16(2): 174-181.
Vancouver	Tuna G. E. , Ekren Aşıcı G. S. , Ulutaş P. A. Serum C-Reactive Protein, Procalcitonin and Ceruloplasmin Concentrations in Dogs with Naturally İnfected Ehrlichiosis. Kocatepe Veterinary Journal. 2023; 16(2): 174-181.
IEEE	G. E. Tuna , G. S. Ekren Aşıcı ve P. A. Ulutaş , "Serum C-Reactive Protein, Procalcitonin and Ceruloplasmin Concentrations in Dogs with Naturally İnfected Ehrlichiosis", , c. 16, sayı. 2, ss. 174-181, Haz. 2023, doi:10.30607/kvj.1238703