Tuba GÜLER, Yeşim GARİP, Pelin YILDIRIM, Rabia TERZİ

Semptomatik diz osteoartritinde vitamin D düzeyi: klinik ve radyolojik parametrelerle ilişkisi

Amaç: 45-60 yaş arası kadınlarda D vitamini eksikliği ile diz osteoartriti arasındaki ilişkiyi belirlemeyi amaçladık. Gereç ve yöntem: Çalışmada diz osteoartritli 110 kadın hasta yer aldı. Hastalar vitamin D seviyesine göre iki gruba ayrıldı: 1. grup düşük D vitamini seviyesine sahip (< 20 ng/ml) 65 hasta ve 2. grup ise normal D vitamini seviyesine sahip (>=20 ng/ml) 45 hastayı içerdi. Osteoartritin derecelendirme skalası ile değerlendirildi. Ağrı, tutukluk ve fonksiyonel durum Western Ontario and McMasters Üniversiteleri Osteoartrit İndeksi (WOMAC) ile ölçüldü. Bulgular: Vitamin D eksikliği oranı % 59,09 idi. Ortalama vitamin D seviyesi 1. grupta 9,09 ±3,82; 2. grupta 27,84 ±6,42 idi. Vitamin D düzeyi 1. grupta anlamlı derecede düşüktü (p=0,00). K/L evre 1 (%28,89) ve K/L evre 2 (%64,44) sıklıkla grup 2'de daha fazla iken, evre 3 (%38,46) ve evre 4 (%15,38) grup 1'de fazla bulundu. 1. grup, 2. gruba göre anlamlı derecede yüksek radyografik evrelere sahipti (p=0,00). 1. gruptaki hastaların WOMAC skorları anlamlı derecede yüksekti (p=0,00). K/L skorları, VAS-ağrı ve WOMAC skorları ile korele bulundu (p=0,00). K/L skorları vücut kitle indeksi (VKİ) ile anlamlı korelasyon göstermedi (p=0, 82). Sonuç: Vitamin D eksikliği ağrı, tutukluk, fonksiyonel ve radyolojik durum açısından diz osteoartriti ile ilişkilidir.

Vitamin D status in symptomatic knee osteoarthritis: association with clinical and radiological parameters

Objective: We aimed to examine the relationship between vitamin D deficiency and knee osteoarthritis in women aged 45-60. Methods: 110 female patients with knee osteoarthritis were included. Patients were divided into two groups according to vitamin D level: group 1 included 65 patients with low vitamin D (< 20 ng/ml), and group 2 included 45 patients with vitamin D in normal ranges (>=20 ng/ml). Severity of osteoarthritis was evaluated by KellgrenLawrence (KL). Pain, stiffness and functional status were measured by Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC). Results: Rate of vitamin D deficiency was 59.09%. Mean vitamin D level was 9.09±3.82 in group 1 and 27.84±6.42 in group 2. Vitamin D was significantly lower in group 1 (p=0.00). K/L grade 1(28.89%) and 2(64.44%) were most frequently found in group 2, whereas grade 3(38.46%) and 4(15.38%) were found in group 1. Group1 had significantly higher radiographic grades than group 2 (p=0.00). Patients in group 1 scored significantly higher in WOMAC (p=0.00). K/L scores were correlated with VASpain and WOMAC scores (p=0.00). K/L scores showed no significant correlation with body mass index (BMI) (p=0.82). Conclusion: Vitamin D deficiency is associated with knee OA in terms of pain, stiffness, functional and radiological status.

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