İntrauterin Gelişme Geriliğinde Plasental Difüzyon Ağırlıklı Görüntülemenin Tanıya Katkısı

GİRİŞ ve AMAÇ: Bu çalışmanın amacı, intrauterin gelişme geriliği (İUGG) bulunan hastalarda plasental difüzyon ağırlıklı görüntülemenin (DAG) tanısal değerini araştırmaktır. YÖNTEM ve GEREÇLER: Çalışmaya ultrason(US) ile tanı konulan 25 İUGG' li fetus ve fetal gelişiminin normal olarak saptandığı 22 fetus, toplam 47 olgu dahil edildi. Hasta ve kontrol olguların 3T Manyetik Rezonans (MR) ünitesinde difüzyon ağırlıklı eko-planar (EPI) görüntüleri elde edilerek plasentalarından b-0 ve b-1000 değerleriyle Görünür Difüzyon Katsayısı - Apparent Diffusion Coefficient (ADC) ölçümleri ROI kullanılarak gerçekleştirildi. Ek olarak doğumdan sonra iki grubun doğum ağırlıkları ve prenatal fetal DAG ölçümleri karşılaştırıldı. BULGULAR: İUGG'li plasentaların b0, b1000 ve ADC değerleri İUGG olmayanlara göre anlamlı olarak azaldığı saptandı (p

Diagnostic Contribution of Plasental Diffusion Weighted Imaging in Intrauterine Growth Restriction

INTRODUCTION: The aim of this study is to investigate the diagnostic value of placental diffusion-weighted imaging (DWI) in patients with intrauterine growth retardation (IUGR). METHODS: A total of 47 fetuses with 25 IUGRs diagnosed with ultrasound(US) and 22 fetuses with normal fetal development were included in the study. Diffusion weighted echo-planar (EPI) images were obtained from 3T Magnetic Resonance (MR) units of patient and control subjects and Appearance Diffusion Coefficient (ADC) measurements with b- 0 and b-1000 values were obtained from the placenta using ROI. In addition, birth weights of both groups and prenatal fetal DWI measurements were compared after birth. RESULTS: B0, b1000 and ADC values of placenta in IUGR were found to be significantly decreased compared to those without IUGR (p

___

  • 1. Lackman F, Capewell V, Gagnon R, Richardson B. Fetal umbilical cord oxygen values and birth to placental weight ratio in relation to size at birth. Am J Obstet Gynecol. 2001;185: 674-82.
  • 2. Zeitlin J, Ancel PY, Saurel-Cubizolles MJ, Papiernik E. The relationship between intrauterine growth restriction and preterm delivery: an empirical approach using data from a European case–control study. BJOG. 2000;107:750-8.
  • 3. Tolsa CB, Zimine S, Warfield SK, Freschi M, Sancho Rossignol A, Lazeyras F, et al. Early alteration of structural and functional brain development in premature infants born with intrauterine growth restriction. Pediatr Res. 2004;56: 132-8.
  • 4. Bursztyn M, Ariel I. Maternal–fetal deprivation and the cardiometabolic syndrome. J Cardio metab Syndr. 2006;1:141-5.
  • 5. Hata T, Tanaka H, Noguchi J, Hata K. Threedimensional ultrasound evaluation of the placenta. Placenta. 2011;32:105-15.
  • 6. Bonel HM, Stolz B, Diedrichsen L, Frei K, Saar B, Tutschek B et al. Diffusion-weighted MR imaging of the placenta in fetuses with placental insufficiency. Radiology. 2010;257:810-9.
  • 7. Maier SE, Sun Y, Mulkern RV. Diffusion imaging of brain tumors. NMR Biomed. 2010;23:849-64.
  • 8. Hadlock FP, Harrist RB, Sharman RS, Deter RL, Park SK. Estimation of fetal weight with the use of head, body, and femur measurements—a prospective study. Am J Obstet Gynecol. 1985;151:333-7.
  • 9. Loughna P, Chitty L, Evans T, Chudleigh T. Fetal size and dating:charts recommended for clinical obstetric practice. Ultrasound. 2009;17:161- 7.
  • 10. Bamfo JE, Odibo AO. Diagnosis and management of fetal growth restriction. J Pregnancy. 2011;2011:640715.
  • 11. Lausman A, Kingdom J. Intrauterine growth restriction: screening, diagnosis, and management. J Obstet Gynaecol Can. 2013; 35:741-57.
  • 12. Schneider MM , Berman JI , Baumer FM , Glass HC, Jeng S, Jeremy RJ, et al . Normative apparent diffusion coefficient values in the developing fetal brain. AJNR Am J Neuroradiol 2009 ; 30:1799–803.
  • 13. Savelli S , Di Maurizio M , Perrone A , Tesei J, Francioso A, Angeletti M, et al . MRI with diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) assessment in the evaluation of normal and abnormal fetal kidneys: preliminary experience Prenat Diagn 2007;27:1104–111
  • 14. Carter AM. Evolution of factors affecting placental oxygen transfer.Placenta. 2009;30:S19- S25.
  • 15. Song, F, Wu, W, Qian, Z, Zhang, G, Cheng, Y. Assessment of the Placenta in Intrauterine Growth Restriction by Diffusion-Weighted Imaging and Proton Magnetic Resonance Spectroscopy: A Pilot Study. Reprod Sci. 2017;24:575-81.
  • 16. Kaufmann P, Black S, Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod. 2003;69(1):1-7.
  • 17. Dunn WB, Brown M, Worton SA, Crocker IP, Broadhurst D, Horgan R, et al. Changes in the metabolic footprint of placental explant-conditioned culture medium identifies metabolic disturbances related to hypoxia and pre-eclampsia. Placenta. 2009;30:974-80.
  • 18. Heazell AE, Brown M, Dunn WB, Worton SA, Crocker IP, Baker PN, et al. Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers. Placenta. 2008;29:691-8.
  • 19. Takeuchi M, Matsuzaki K, Harada M. Preliminary observations and clinical value of Nacetyl resonances in ovarian tumours using in-vivo proton MR spectroscopy at 3 T. Eur Radiol. 2011;21:2640-6.
Kocaeli Tıp Dergisi-Cover
  • ISSN: 2147-0758
  • Başlangıç: 2012
  • Yayıncı: -
Sayıdaki Diğer Makaleler

Mrı and Accompanying Knee Pathologies in the Radial Tears of Medial and Lateral Menisci

Yüksel IŞIK

Elemental Composition Of Surgically Removed Carotid Plaques

AYHAN OLCAY, ERDEM TEZCAN, Emir CANTÜRK, Bekir İNAN, Barış AKDEMİR, Onur YOLAY

Tranperitoneal Laparoscopic Renal Cyst Decortication: A Single Center Experince

HACI İBRAHİM ÇİMEN, Hacı Can DİREK, FİKRET HALİS, HASAN SALİH SAĞLAM, AHMET GÖKÇE

Hemoroidektomide Miligan Morgan ile Ferguson Tekniklerinin Karşılaştırılması

Serdar ÖTER, Volkan ÖTER

D Vitamini Düzeylerinin Deri Hastalıkları Üzerine Etkisinin Retrospektif Değerlendirilmesi

Nurşad ÇİFCİ

Vokal Kord Paralizilerinin, Klinik ve Etyolojik Değerlendirilmesi

saime SAĞIROĞLU, NAGİHAN BİLAL, SELMAN SARICA, Ayşegül ERDOĞAN, Şükran PEKER, İSRAFİL ORHAN

Periton Diyaliz Hastalarında Trombosit Agregasyonu Üzerinde Periferik Trombosit ve Lökosit Sayılarının Etkileri

Serkan BAKIRDÖĞEN, Necmi EREN, Mustafa Baki ÇEKMEN, Sibel GÖKÇAY BEK, Sara YAVUZ, Ümit BİLGİLİ, Mehmet TUNCAY, Ant UZAY, Ahmet YILMAZ

Kliniğimizdeki İntrauterin Fetal Ölümlerin Analizi

Hasan TERZİ, Ünal TÜRKAY, Bahar SARIİBRAHİM ASTEPE, Mehmet SALICI

Do Pre-treatment Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratios Predict Success of Medical Treatment in Patients with Tubo-ovarian Abscess?

Fatma AYDIN, Alper BİLER, Cüneyt Eftal TANER, İbrahim Egemen ERTAŞ

Parotis Bezinin Tekrarlayan Çok Odaklı Pleomorfik Adenomu, Olgu Sunumu

Mustafa CANTÜRK, Vasıf SOYSAL, Şafak ATAHAN, Abdullah GÜNEN, Özgür Çakır KAYA