D Vitamini Düzeylerinin Deri Hastalıkları Üzerine Etkisinin Retrospektif Değerlendirilmesi

GİRİŞ ve AMAÇ: D vitamini, immünmodülatör ve antiinflamauvar etkilerinden dolayı deri hastalıklarıyla yakından ilişkilidir. Dermatolojik hasta grubumuzda D vitamini düzeylerini saptamak ve D vitamininin farklı dermatolojik hastalıklar üzerindeki etkisini değerlendirmek amacıyla bu çalışmayı yaptık. YÖNTEM ve GEREÇLER: Hastanemiz Biyokimya laboratuarında Ocak 2013 ile Aralık 2013 tarihleri arasında D vitamin düzeyi diğer klinikler tarafından takip altında olan ve her hangi bir nedenle dermatoloji polikliniğine başvurmuş olan yetişkin hastaların tıbbi kayıtları retrospektif olarak incelendi. Hastaların demografik özellikleri, klinik ve laboratuvar bulguları SPSS 17 programında analiz edildi. BULGULAR: 548 hastanın 487’si (%88.9) kadın, yaş ortalaması 42.24±13.20 (18-65) yıl, ortalama D vitamini düzeyi 13.34±9.62 ng/ml bulundu. Hastaların %60.2’sinde ek olarak başka kronik hastalıklar vardı. Yetmiş dokuz hastada (%14.4) ağır eksiklik (30 ng/ml). Hastalarımızda en az bir tane olmak üzere birçok deri bulgusu saptandı. Hasta grubumuzda en sık görülen deri hastalıkları; dermatitler (%32.3), dermatofitozlar (%19.1), kserosis (%16.9), akne vulgaris (%10.7), psoriasis (%5.6), bakteriyel ve viral deri hastalıkları (%5.6), seboreik dermatit (%5.2), saç ve tırnak bozukluğu (%4.3), Behçet hastalığı (%2.5), rozasea (%2.18), pigmentasyon bozukluğu (%2.2) ve ürtiker (%2.0) idi. Bunların D vitamini düzeyleri arasındaki fark istatiksel olarak anlamlı değildi (p>0.05). TARTIŞMA ve SONUÇ: D vitamini pek çok deri hastalığını etkilemektedir. Dermatolojik hasta grubunda D vitamini düzeyinin değerlendirilmesi gerekmektedir.

Retrospective Evaluation Of Effects Of Vitamin D Levels On Skin Diseases

INTRODUCTION: Vitamin D is closely related to skin diseases due to its immunomodulatory and anti-inflammatory effects. The aim was to determine vitamin D levels in our patient group and to evaluate the effect of vitamin D on different dermatological diseases. METHODS: Between January 2013-December 2013, medical records of the adult patients who applied to dermatology clinic and whose vitamin D levels were under follow-up in other clinics, were retrospectively reviewed. Demographic, clinical, laboratory variables of patients were analyzed by using SPSS version 17. RESULTS: 487 of 548 patients were female (88.9%), the mean age of the patients was 42.24±13.20 years old (18 - 65 years), the mean vitamin D level was 13.34±9.62 ng/ml. 330 patients (60.2%) were followed by other clinics due to various chronic diseases. Heavy deficiency (30 ng/ml) levels. At least one skin diseases were found in patients. The most common skin diseases were dermatitis (32.3%), dermatophytosis (19.1%), xerosis (16.9%), acne vulgaris (10.7%), psoriasis (5.6%), bacterial and viral infections (5.6%), seborrheic dermatitis (5.2%), hair and nail disorders (4.3%), Behçet’s disease (2.5%), rozasea (2.18%), pigmentation disorders (2.2%), urticaria (2.0). The difference between the levels of vitamin D was not statistically significant (p>0.05). DISCUSSION AND CONCLUSION: Vitamin D affects many skin diseases. In the dermatological patient group, vitamin D needs to be evaluated.

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