İlk Atak Şizofreni Hastalarında Antipsikotik Tedaviye Yanıtı Belirleyen Yordayıcı Faktörler

Şizofreni kronik ve yeti yitimine yol açan bir hastalıktır. Özellikle ilk psikotik atağını geçiren şizofreni hastalarında uygulanan tedaviye yeterli yanıt elde edilebilmesi, hastalığın gidişinin belirlenmesi açısından önemlidir. Antipsikotik ilaçlarla tedaviye verilen yanıtın yordanabilmesi, gereksiz ilaç kullanımını azaltıp, tedaviye uyumu arttırarak, etkin bir klinik yanıt elde edilebilmesine olanak tanır. Bu bağlamda konunun önemi göz önünde bulundurularak ilk atak şizofreni hastalarında antipsikotik tedaviye yanıtı belirleyen yordayıcı faktörlerle ilgili olarak bu derleme düzenlenmiştir. Bu derleme için Pubmed veri tabanında elektronik arama yapılmıştır. Bu alanda yapılan çalışmalarda gerek farmakolojik, nörogörüntüleme ve elektroensefalografi (EEG) bulgularını içeren biyolojik, gerek tedavi edilmemiş psikoz süresi, tedavide kullanılan antipsikotik ajanlar, siliknörolojik belirtiler, psikotik belirti türü ve şiddeti ile frontal lob işlevinin nörofizyolojik belirtecini (NoGo- Anteriorization, NGA) içeren klinik değişkenlerle ilaç tedavisine yanıt arasında değişik bağlantılar kurulmuş olmakla beraber daha ileri klinik çalışmalara gereksinim olduğu sonucuna varılmıştır .

Predictive Factors of Antipsychotic Treatment Response in Patients With First Episode Schizophrenia

Schizophrenia is an illness which is chronic that leads todisability. Particularly obtaining sufficient treatmentresponse in patients with first episode schizophrenia isimportant in determining the course of the illness.Predicting treatment response with antipsychotic drugswould allow to obtain efficient clinical response byreducing unnecessary drug use and enhance the adherence to treatment. In this context, considering theimportance of topic, this review is written out relevant topredictive factors of antipsychotic treatment response inpatients with first episode schizophrenia. Electronicsearch was conducted for this review in Pubmed database. Although there are varied links between drugresponse and both biological, including pharmacological, neuroimaging and electroencephalography (EEG)findings, and clinical, including duration of untreatedpsychosis, antipsychotic agents which are used in treatment, soft neurological signs, kind and severity of psychotic symptoms and neurophysiologic indicator offrontal lobe function (NoGo Anteriorization, NGA), variables in studies which are conducted in this field, thereis a need for further studies as a conclusion

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