İlaca Bağlı Hipomanik /Manik Nöbet Geçiren Olguların Klinik Ve Sosyodemografik Özelliklerinin ıncelenmesi

Amaç: Bu çaly?mada; antidepresan tedavi syrasynda hipomanik/manik kayma gözlenen hastalaryn geriye dönüksosyodemografik ve klinik özelliklerinin ara?tyrylmasyamaçlanmy?tyr. Gereç ve Yöntem: Bu çaly?ma, ÖzelAdana Hastanesi Psikiyatri poliklini?ine Aralyk 2012A?ustos 2015 arasynda ayaktan tedavi için ba?vuran, 18ya?yny doldurmu?, DSM-IV tany kriterlerine göre majordepres yon (HAM-D skoru >32) tanysy konmu? antidepresan tedavi almy? ve antidepresan tedavi altynda ikentakiplerinde hipomanAd?yaman Üniversitesi E?itim ve Ara?t?rma Hastanesiik (YMRS skoru >13) ve manik(YMRS skoru >21) kayma gözlenmi? olan hastalaryngeriye dönük dosya bilgilerinin taranmasy ve sosyodemografik verilerinin istatistiksel olarak dökümünün eldeedilmesi ile yapylmy?tyr. Anlamlylyk düzeyi p13) atak geçirdi?i tespit edildi.

Evaluation of Clinical and Sociodemographic Features of the Patients' Who Had Hypomanic/Manic Switch Due to Drugs

Objectives: The aim of this study was to retrospectivelyevaluate sociodemographic and clinical features ofpatients who had hypomanic/manic switch during antidepressant treatment. Methods: In this study statisticalevaluations of retrospective chart reviews of majordepression patients who admitted to Private AdanaHospital between December 2012-August 2015, whowere above 18 years of age, who met DSM-IV diagnosticcriteria for major depressive disorder (HAM-D score>32), and who switched to hypomania (YMRS score>13) or mania (YMRS score >21) during antidepressanttreatment were performed. Significance level wasdefined to be p<0.05. Statistical Package for SocialSciences (SPSS) version 21.0 was used for statistical evaluation of the data. Results: This study included 33patients (21 females 12 males) who had manic or hypomanic switches during antidepressant treatment formajor depression. Mean age of the females was 32,57±7,06, and males was 28,50±6,84. Mean initial HAM-Dscore of these major depression patients was detected tobe 35.84±5.66. Mean duration of depressive illness was7.18±4.91 years and percentage of hospitalization fordepressive episodes was 1.72±1.68%. Seventeenpatients (51.5%) had a family history for bipolar disorder. A stressor was detected in 75.8% of the patients(n=25). Seasonality of the episodes was positive in45.8% (n=16) of the patients. Conclusion: Seventeenpatients (51.5%) had previous suicidal attempts. Afterantidepressant treatment 19 patients had manic (YMRS>21), and 14 patients had hypomanic (>13) episodes.

Kaynakça

Akdemir A, Örsel S, Da? Y, ve ark. (1996). Hamilton Depresyon Derecelendirme Ölçe?i'nin geçerli?i, güvenilirli?i ve klinikte kullanymy. Psikiyatri Psikoloji Psikofarmakoloji Dergisi 4, 251-9.

Akiskal HS, Khani MK, Scott-Strauss A (1979). Cyclothymic temparement disorders. Psychyatr. Clin. North Am. 2, 527-554.

Akiskal HS, Hantouche EG, Allilaire JF ve ark. (2003) Validating antidepressant-associated hypomania (bipolar III): a systematic comparison with spontaneous hypomania (bipolar II). J Affect Disord 73: 65-74.

Amerikan Psikiyatri Birli?i (1994) Mental Bozukluklaryn Tanysal ve Sayymsal El Kitaby, dördüncü basky (DSM-IV) (Çev. Ed: E Köro?lu). Hekimler Yayyn Birli?i, Ankara, 1995.

American Psychiatric Association, 2000. Diagnostic and Statistical Manual of Mental Disorders, fourth ed. American Psychiatric Association, Washington, DC (text revision).

Balderassini RJ, Faedda GL, Hennen J (2005). Risk of mania with serotonin reuptake inhibitors vs. tricyclic antidepressants in children, adolescents and young adults. Arch Pediatric Adolesc Med 159:298-299.

Balderassini RJ, Faedda GL, Offidani E ve ark. (2013). Antidepressant-associated mood-switching and transition from unipolar major depression to bipolar disorder: A review. J Affect Disord 148:129-135.

Baldessarini RJ, Tondo L, Vazquez GH ve ark. (2012). Age at onset versus family history and clinical outcomes in 1,665 inter- national bipolar-I disorder patients. World Psychiatry 11:40-6.

Bottlender R1, Sato T, Kleindienst N ve ark (2004). Mixed depressive features predict maniform switch during treatment of depression in bipolar I disorder. J Affect Disord 78:149-52.

Berk M, Dodd S (2005). Are treatment emergent suicidality and decreased response to antidepressants in younger patients due to bipolar disorder being misdiagnosed as unipolar depression? Med Hypotheses 65: 39-43.

Bunney WE (1978). Psychopharmacology of the switch process in affective illness. In: Lipton, M.A., DiMascio, A., Killam, K.F., (Eds.), Psychopharmacology; A generation of Progress. Raven Press. New York, pp. 1249-1259.

Chun BJ, Dunner DL (2004). A review of antidepressant- induced hypomania in major depression: suggestions for DSM- V. Bipolar Disord 6:32-42.

Dudek D, Siwek M, Zielinska D ve ark. (2013). Diagnostic con- versions from major depressive disorder into bipolar disorder in an outpatient setting: results of a retrospective chart review. J Affect Disord 144:112-5.

Dünya Sa?lyk Örgütü (1992) ICD-10 Ruhsal ve Davrany?sal Bozukluklar Synyflandyrmasy. (Çev. Ed: MO Öztürk, B Ulu?; Çev.: F Çuhadaro?lu, I Kaplan, G Özgen, MO Öztürk, M Rezaki, B Ulu?).Türkiye Sinir ve Ruh Sa?ly?y Derne?i Yayyny, Ankara, 1993.

Emslie GJ, Heilegenstein JH, Wagner KD ve ark. (2002). Fluoxetine for acute treatment of depression in children and adolescents: placebo-controlled, randomized clinical trial.J Am Acad Child Adolesc Psychiatry 41:1205-15.

Fava GA, Mangelli L (2003). Mania associated with venlafaxine discontinuation. Int J Neuropsychopharmacol 6: 89-90.

Fiedorowicz JG, Endicott J, Leon AC ve ark. (2011). Subthreshold hypomanic symptoms in progression from unipo- lar major depression to bipolar disorder.Am J Psychiatry 168:40- 8.

Fiedrowitz JG, Endicott J, Solomon DA ve ark. (2012). Course of Illness following prospectively observed mania or hypomania in individuals presenting with unipolar depression. Bipolar Disord 14:664-71.

Ghaemi SN, Ko JY, Goodwin FK (2001). The bipolar spectrum and the antidepressant view of the world. J Psychiatr Pract 7: 287-97.

Ghaemi SN, Lennox MS, Baldessarini RJ (2001). Effectiveness and safety of antidepressants in long term treatment of bipolar disorder. J Clin Psychiatry 62:565-569.

Ghaemi SN, Hsu DJ, Soldani F, Goodwin FK (2003). Antidepressants in bipolar disorder: the case for caution. Bipolar Disord 5:421-433

Goldberg JF, Truman CJ (2003). Antidepressant-induced mania: an overview of current controversies. Bipolar Disord 5: 407-20. Goodwin FK, Jamison KR (1990). Medical Treatment of Acute Bipolar Depression. Manic Depressive Illness, Oxford, Oxford University Press, s. 643-651

Henry C. Sorbara F. Lacoste J ve ark. (2001). Antidepressant- induced mania in bipolar patients: identification of risk factors. J. Clin. Psychiatry 62, 249-255.

Joseph MF, Youngstorm EA, Soares JC (2009). Antidepressant- coincident mania in children and adolescents treated with selec- tive serotonin reuptake inhibitors. Future Neurol 4:87-102.

Karada? F, Oral ET, Yalçyn FA, Erten E (2001). Young Mani Derecelendirme Ölçe?inin Türkiye'de Geçerlik ve Güvenilirli?i. Türk Psikiyatri Dergisi 13(2), 107-114.

Leverich GS, Altshuler LL, Frye MA ve ark. (2006). Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of ven- lafaxine, sertraline, and bupropion as adjuncts to mood stabiliz- ers. Am J Psychiatry 163(2):232-9.

Levy D, Kimhi R, Barak Y ve ark. (1998). Antidepressant asso- ciated mania: a study of anxiety disorders patients. Psychopharmacology (Berl) 136:243-246.

Navarro V, Gasto C, Guarch J ve ark. (2014). Treatment and outcome of antidepressant treatment-associated hypomania in unipolar major depression: A 3-year follow-up study. J Affective Disosrders 155: 59-64.

Offidani E, Fava GA, Tomba E, Ross J ve ark. (2013). Excessive mood-elevation with antidepressant treatment of juvenile depressive and anxiety disorders in childhood and adolescence: a systematic review. Psychother Psychosom 82(3):132-41.

Post RM (2000) Mood Disorders: Treatment of Bipolar Disorders. Comprehensive Textbook of Psychiatry, 7. basky, 1. cilt, BJ Sadock, VA Sadock (Eds), Philadelphia, Lippincott Williams&Wilkins, s. 1417.

Rybakowski JK, Suwalska A, Lojko D ve ark. (2005). Bipolar mood disorders among Polish psychiatric outpatients treated for major depression.J Affect Disord 84:141-7.

Serretti A, Artioli P, Zanardi R, Rossini D (2003). Clinical fea- tures of antidepressant associated manic and hypomanic switch- es in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 27: 751-757.

Sherese A, Milev R (2003). Switch to mania upon discontinua- tion of antidepressants in patients with mood disorders: a review of the literature. Can J Psychiatry 48:258-64.

Stoll AL, Tohen M, Baldessarini RJ ve ark. (1993). Shifts in diagnostic frequencies of schizophrenia and major affective dis- orders at six North American psychiatric hospitals, 1972-1988. Am J Psychiatry 1993;150:1668-73.

Tondo L, Lepri B, Cruz N, Balderassini RJ (2010). Age at onset in 3014 Sardinian bipolar and major depressive disorder patients. Acta Pyschiatrica Scandinavica 121:446-52.

Tondo L, Vázquez G, Baldessarini RJ (2010). Mania associated with antidepressant treatment: comprehensive meta-analytic review. Acta Psychiatr Scand.121:404-14.

Tondo L, Baldessarini RJ, Vázquez G ve ark (2013). Clinical responses to antidepressants among 1036 acutely depressed patients with bipolar or unipolar major affective disorders.Acta Psychiatr Scand 127:355-64.

Truman CJ, Goldberg JF, Ghaemi SN ve ark. (2007). Self- reported history of manic/hypomanic switch associated with antidepressant use: data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). J Clin Psychiatry 68:1472-79.

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