REJENERATİF ENDODONTİDE İSKELE BİYOMATERYALLERİ

Doku mühendisliğiyle; kanser, travma ya da hastalıklar nedeniyle kaybolan dokunun fizyolojik ve fonksiyonel restorasyonu hedeflenir. Rejenerasyon kavramı multidisipliner bir yaklaşımla; kök hücreler, iskele ve büyüme faktörlerini içermektedir. Tedavilerin daha başarılı olabilmesi için kök hücrelerinin organizasyonu ve vaskülarizasyonu sırasında doku oluşumunu destekleyen geçici ekstrasellüler matrikslere (iskeleler) ihtiyaç vardır. İskele tasarımı, doku mühendisliği için kritik öneme sahiptir. Doku mühendisliğiyle, diş hekimliği alanında da umut vaat edici sonuçlara ulaşılmıştır. Araştırma verileri; dişin tüm kronu yerine daha küçük boyutlarda diş dokusunun üretilebildiğini göstermiştir. Rejeneratif endodontik tedavilerde, doğal ve doğal olmayan (fabrikasyon) iskeleler kullanılır. Bu derlemenin amacı, rejeneratif tedavilerde kullanılan iskele çeşitlerinin tanımlanması ve güncel literatür çalışma sonuçlarının değerlendirilmesidir.

Anahtar Kelimeler:

Rejeneratif endodonti, iskeleler, kök hücreler, büyüme faktörleri

Scaffolding Biomaterials in Regenerative Endodontics

In tissue engineering; physiological and functional restoration of tissue lost due to cancer, trauma or diseases is targeted. The concept of regeneration with a multidisciplinary approach includes stem cells, scaffolds and growth factors. For successful treatments, artificial extracellular matrices (scaffolds) that support tissue formation during the organization and vascularization of stem cells are needed. Scaffolding design is critically important for tissue engineering. Tissue engineering has also shown promising results in the field of dentistry. Research data showed that smaller sizes of dental tissue can be produced instead of the whole crown of the tooth. In regenerative endodontic treatments, natural and fabricated scaffolds are used. The aim of this review is to define the types of scaffolding used in regenerative treatments and to evaluate the current literature study results.

Keywords:

Regenerative endodontics, scaffolds, stem cells, growth factors,

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