Hakan BOYUNAĞA, Nermin DİNDAR BADEM, Tülay MORTAŞ

MISIR ŞURUBUNUN METABOLİZMADA OLUŞTURDUĞU ANARŞİ VE HASTALIKLARLA İLİŞKİSİ

Yüksek fruktoz içeren mısır şurubunun tüketimi son elli yılda tüm dünyada artmıştır. Hazır gıdalara bol miktarda ilave edilen ve içeriğinde yüksek fruktoz bulunduran mısır şurubu metabolizmada anarşiye yol açmaktadır. Fruktoz, bağırsak ve karaciğer hücre yüzeyinde bulunan kanallara (GLUT: glukoz transporter) yüksek afinitesi nedeni ile hızla karaciğer ve pankreas hücrelerine dolmaktadır.Katabolizmasında yer alan enzimlerin kinetik özelliklerinin diğer şekerlerden farklı olması nedeni ile karaciğerde yağ asidi ve kolesterol sentezine yönlenmektedir. Ayrıca aşırı alındığında katabolizmasında yer alan fruktokinaz enzimi nedeni ile ürik asit oluşumunu arttırmakta ve gut artriti, gut nefritine yol açabilmektedir.Yüksek fruktoz içeren mısır şurubunun aşırı tüketimine bağlı olarak, organ içi yağlanma, obezite, insülin direncinde artış, ürik asit artışı, hipertansiyon gibi birçok patoloji tetiklenmektedir. Üretimindeki izolasyon aşamalarında civa ve karbonil bileşikleri bulaşımı da farklı patolojilere yol açabilmektedir.Oluşturabileceği patolojiler göz önüne alındığında, glukoz gibi diğer şekerlerden farklı bir metabolizmaya sahip olan fruktozun mısır şurubuyla aşırı alınmasına çok dikkat edilmesi gerekmektedir.

Anahtar Kelimeler:

Metabolik anarşi, yüksek fruktozlu mısır şurubu, fruktoz şurubu ve hastalıklar

Anarchy in the Metabolism Due to Corn Syrup and Its Relationship with Diseases

The consumption of corn-syrup with high fructose content has increased in recent fifty years throughout the World. Corn-syrup which is added into the fast-foods and contains high fructose concentrations causes a chaos in metabolism. Due to its high affinity to the channels (GLUT: glucose transporter) located on the intestinal and hepatic cellular surfaces, fructose is rapidly accumulated in the liver and pancreas. Additionally, since kinetics of the enzymes functioning in its catabolism differ than those in other sugars, synthesis of fatty acids and cholesterol is mainly dominated in the liver. In the case of increased fructose intake, fructokinase enzyme roling in fructose catabolism may also cause gout arthritis and gout nephritis by means of increasel levels of uric acid. Overconsumption of corn-syrup with high fructose content may also trigger various pathologies including intra-organ fat deposition, obesity, increased insülin resistance, increased uric acid, hypertension. Some additional pathologies may be seen due to contamination of mercury and carbonyl compounds during the isolation steps of production. As a conclusion, attention should be paid to the clinical concerns appearing when there is an excessive intake of fructose inside the corn-syrup which has a rather different metabolism than other sugars like glucose.

Keywords:

Metabolic anarchy, high fructose corn syrup, fructose corn syrup and diseases,

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