Zeynep YEĞİN, Filiz ÖZEN, Haydar KOÇ, Asıf YILDIRIM, Recep BÜYÜKALPELLİ

MESANE TÜMÖRLÜ HASTALARIN KANLARINDA EPİGENETİK BİYOBELİRTEÇLER OLARAK PROTOKADERİN GEN AİLESİ ÜYELERİ PCDH8, PCDH10 VE PCDH17’NİN ARAŞTIRILMASI

Amaç: Çalışmanın amacı mesane tümörlü hastalarda ve sağlıklı kontrollerde protokaderin gen ailesine ait olan protokaderin 8 (PCDH8), protokaderin 10 (PCDH10) ve protokaderin 17 (PCDH17) genlerinin periferal kan DNA metilasyon profillerini analiz ederek bu profillerin tümör-spesifik olası etkilerini değerlendirmektir. Araştırılan üç genin metilasyon profiliyle spesifik demografik ve/veya klinikopatolojik veriler arasındaki olası ilişkinin araştırılması da çalışmanın ikinci hedefidir.

Anahtar Kelimeler:

Mesane kanseri, DNA metilasyonu, periferik kan, PCDH8, PCDH10, PCDH17

The Investigation of Protocadherin Gene Family Members PCDH8, PCDH10, and PCDH17 as Epigenetic Biomarkers in Blood Samples of Patients with Bladder Tumor

Objective: The aim of the study was to evaluate the potential tumor-specific effects of peripheral blood DNA methylation profiles of protocadherin 8 (PCDH8), protocadherin 10 (PCDH10), and protocadherin 17 (PCDH17) genes who belong to the protocadherin gene family, in patients with bladder tumors and healthy controls. The potential association between methylation profiles of the investigated three genes and demographic and/or clinicopathologic data was a second target of the study.

Keywords:

Bladder cancer DNA methylation, peripheral blood, PCDH8, , PCDH10, PCDH17,

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