THE RELATIONSHIP OF THE EFFECT OF INTRA-ARTICULAR PLATELET-RICH PLASMA (PRP) ADMINISTRATION WITH THE SEVERITY OF KNEE OSTEOARTHRITIS

Amaç: Trombositten zengin plazma uygulamaları son dönemde diz osteoartritinde cerrahi dışı tedaviler arasında yer almaya başlamıştır. Plasebo ve proloterapi gibi tedavilere üstünlüğü gösterilmiştir. Ancak halen erken dönem ve geç dönem diz osteoartriti üzerine etkisinin değişiklik gösterip göstermediği tam net değildir. Biz bu çalışmamızda farklı evredeki diz osteoartriti olan hastalarda tek doz trombositten zengin plazma uygulamasının etkinliğini karşılaştırmayı amaçladık. 

Eklem İçi Uygulanan Trombositten Zengin Plazmanın (TZP) Etkisinin Diz Osteoartritinin Şiddeti ile İlişkisi

Objective: Platelet-rich plasma applications have recently become one of the non-surgical treatments in knee osteoarthritis. It has been shown to be superior to treatments such as placebo and prolotherapy. However, it is not entirely clear whether its effect on early or late knee osteoarthritis varies. In this study, we aimed to compare the effectiveness of single dose platelet-rich plasma administration in patients with different stages of knee osteoarthritis. 

___

  • 1. Price AJ, Alvand A, Troelsen A, Katz JN, Hooper G, Gray A et al. Knee replacement. Lancet. 2018;392(10158):1672-82.
  • 2. Dhillon MS, Patel S, John R. PRP in OA knee - update, current confusions and future options. SICOT J. 2017;3:27.
  • 3. Patel S, Dhillon MS, Aggarwal S, Marwaha N, Jain A. Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. Am J Sports Med. 2013;41(2):356-64.
  • 4. Gobbi A, Fishman M. Platelet-rich plasma and bone marrow-derived mesenchymal stem cells in sports medicine. Sports Med Arthrosc Rev. 2016;24(2):69-73.
  • 5. Braun HJ, Kim HJ, Chu CR, Dragoo JL. The effect of platelet-rich plasma formulations and blood products on human synoviocytes: implications for intra-articular injury and therapy. Am J Sports Med. 2014;42(5):1204-10.
  • 6. Celik D, Coskunsu D, Kilicoglu O. Translation and cultural adaptation of the Turkish Lysholm knee scale: ease of use, validity, and reliability. Clin Orthop Relat Res. 2013;471(8):2602-10.
  • 7. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957;16(4):494-502.
  • 8. Di Y, Han C, Zhao L, Ren Y. Is local platelet-rich plasma injection clinically superior to hyaluronic acid for treatment of knee osteoarthritis? A systematic review of randomized controlled trials. Arthritis Res Ther. 2018;20(1):128.
  • 9. Rahimzadeh P, Imani F, Faiz SHR, Entezary SR, Zamanabadi MN, Alebouyeh MR. The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis. Clin Interv Aging. 2018;13:73-9.
  • 10. Guillibert C, Charpin C, Raffray M, Benmenni A, Dehaut FX, El Ghobeira G et al. Single injection of high volume of autologous pure prp provides a significant improvement in knee osteoarthritis: A prospective routine care study. Int J Mol Sci. 2019;20(6).
  • 11. Martini LI, Via AG, Fossati C, Randelli F, Randelli P, Cucchi D. Single Platelet-Rich Plasma Injection for Early Stage of Osteoarthritis of the Knee. Joints. 2017;5(1):2-6.
  • 12. Levy DM, Petersen KA, Scalley Vaught M, Christian DR, Cole BJ. Injections for knee osteoarthritis: corticosteroids, visco-supplementation, platelet-rich plasma and autologous stem cells. Arthroscopy. 2018;34(5):1730-43.
  • 13. Sucuoglu H, Ustunsoy S. The short-term effect of PRP on chronic pain in knee osteoarthritis. Agri. 2019;31(2):63-9. 14. Huang Y, Liu X, Xu X, Liu J. Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis: A prospective randomized controlled study. Orthopade. 2019;48(3):239-47. 15. Bansal H, Comella K, Leon J, Verma P, Agrawal D, Koka P et al. Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis. J Transl Med. 2017;15(1):141.
  • 16. Frechette JP, Martineau I, Gagnon G. Platelet-rich plasmas: growth factor content and roles in wound healing. J Dent Res. 2005;84(5):434-9.
  • 17. Xing D, Wang B, Zhang W, Yang Z, Hou Y, Chen Y et al. Intra-articular platelet-rich plasma injections for knee osteoarthritis: An overview of systematic reviews and risk of bias considerations. Int J Rheum Dis. 2017;20(11):1612-30.
  • 18. Noth U, Steinert AF, Tuan RS. Technology insight: adult mesenchymal stem cells for osteoarthritis therapy. Nat Clin Pract Rheumatol. 2008;4(7):371-80.
  • 19. Southworth TM, Naveen NB, Tauro TM, Leong NL, Cole BJ. The Use of Platelet-Rich Plasma in Symptomatic Knee Osteoarthritis. J Knee Surg. 2019;32(1):37-45.
  • 20. Fotouhi A, Maleki A, Dolati S, Aghebati-Maleki A, Aghebati-Maleki L. Platelet rich plasma, stromal vascular fraction and autologous conditioned serum in treatment of knee osteoarthritis. Biomed Pharmacother. 2018;104:652-60.
  • 21. Foster TE, Puskas BL, Mandelbaum BR, Gerhardt MB, Rodeo SA. Platelet-rich plasma: from basic science to clinical applications. Am J Sports Med. 2009;37(11):2259-72.
  • 22. Kesikburun S, Tan AK, Yilmaz B, Yasar E, Yazicioglu K. Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy: a randomized controlled trial with 1-year follow-up. Am J Sports Med. 2013;41(11):2609-16.
  • 23. Riboh JC, Saltzman BM, Yanke AB, Fortier L, Cole BJ. Effect of Leukocyte Concentration on the Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis. Am J Sports Med. 2016;44(3):792-800.
  • 24. Kanwat H, Singh DM, Kumar CD, Alka B, Biman S, Aman H. The effect of intra-articular allogenic platelet rich plasma in Dunkin-Hartley guinea pig model of knee osteoarthritis. Muscles Ligaments Tendons J. 2017;7(3):426-34.
Kırıkkale Üniversitesi Tıp Fakültesi Dergisi-Cover
  • ISSN: 2148-9645
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1999
  • Yayıncı: KIRIKKALE ÜNİVERSİTESİ KÜTÜPHANE VE DOKÜMANTASYON BAŞKANLIĞI