Timokinon’un Bupivakainin Neden Olduğu Kardiyotoksisite Üzerine Etkileri

Bupivakain bölgesel anestezide en sık kullanılan lokal anesteziklerden biridir. Yanlışlıkla sistemik dolaşıma verilen aşırı doz bupivakain, ventriküler aritmilere ve kardiyak arreste sebep olabilmektedir. Bupivakaine bağlı hasta ölümlerini azaltmak amacıyla yeni tedavi yöntemlerinin araştırıldığı deneysel çalışmalar yapılmaktadır. Timokinon antienflamatuar, serbest radikal temizleme ve güçlü antioksidan özelliklere sahiptir. Timokinon miyokardiyal iskemi reperfüzyon hasarı ve aritmilere karşı koruyucu etkilidir. Siklofosfamid’in neden olduğu kardiyak toksisiteyi engellediği bildirilmiştir. Ancak, timokinon’un bupivakain’in neden olduğu kardiyak toksisite üzerine etkileri araştırılmamıştır. Bu çalışmanın amacı timokinon’un bupivakain kardiyotoksisitesi üzerine tedavi edici etkisini araştırmaktır. Çalışmamızda 12 adet erkek Wistar albino türü sıçan iki gruba ayrıldı. I Kontrol grubu ve II Timokinon grubu. Bupivakain her iki grupta anestezi altındaki hayvanlara 3 mg/kg/dk dozda kalbin durduğu ana kadar asistoli süresi intravenöz iv yolla infüzyonla verildi. Timokinon grubunda 20 mg/kg/ml dozda timokinon kontrol grubunda ise timokinonun çözücüsü olan 1 ml hacimde 1:1 oranında DMSO/serum fizyolojik karışımı, bupivakain infüzyonundan 10 dakika önce intraperitonal ip. yolla bolus enjeksyon ile verildi. Timokinon verilen grupta bupivakain verildikten sonra, ortalama arteriyal kan basıncı’nın %50 azaldığı zamana kadar geçen süre kontrol grubuna göre anlamlı bir artış göstermiştir Kontrol: 499 ± 26 sn ve timokinon: 714 ± 35 sn, P

Anahtar Kelimeler:

Bupivakain, Kardiyotoksisite, Timokinon, Sıçan

The Effects of Thymoquinone on Bupivacaine-Induced Cardiotoxicity

Bupivacaine is one of the local anesthetics which is most commonly used in regional anesthesia. Bupivacaine which is given in excessive doses to systemic circulation by mistake may lead to ventricular arrhythmias and cardiac arrest. Experimental studies investigating new treatment methods have being conducted to reduce bupivacaine-induced patient deaths. Thymoquinone has anti-inflammatory, free radical scavening and strong antioxidant properties. Thymoquinone is protective agent against myocardial ischemia/reperfusion injury and arrhythmias. It has been reported that thymoquinone inhibits cyclophosphamide-induced cardiac toxicity. However, the effects of thymoquinone on bupivacaine-induced cardiac toxicity have not been researched. The aim of the present study is to research the therapeutic effect of thymoquinone on bupivacaine-induced cardiotoxicity. 12 male Wistar albino rats were divided into two groups in our study. I Control group and II Thymoquinone group. Bupivacaine at a dose of 3 mg/kg/dk was administered in both group via intravenous iv. infusion until the time of cardiac arrest asystole time in anesthetized animals. Thymoquinone, at a dose of 20 mg/kg/ ml and its solvent DMSO/SF mixture 1:1 in a volume of 1 ml was given with bolus injection via intraperitoneal infusion 10 min prior to the bupivacaine infusion respectively in thymoqinone and control groups. The time to 50% decrease in mean arterial blood pressure was significantly increased in the thymoquinone group compared to the control group following the bupivacaine administration Control: 499 ± 26 s and thymoquinone: 714 ± 35 s, P

Keywords:

Bupivacaine, Cardiotoxicity, Thymoquinone, Rat,

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