Kürşad TURGUT, İsmail ŞEN, Mehmet Ege İNCE, Amir NASERİ, Havva SÜLEYMANOĞLU, Merve ERTAN, Vedat SAĞMANLIGİL

The End-systolic Wall Stress/End-systolic Volume Index Ratio for Systolic Function in Anatolian Shepherd Dogs with Stage B2 Degenerative Mitral Valve Disease

This study was performed to evaluate the end-systolic wall stress/end-systolic volume index ratio (ESWS/ESV-I) for LV systolic function in Anatolian shepherd dogs (ASHs) with stage B2 degenerative mitral valve disease (DMVD). Thirty-eight adult ASHs with DMVD (experimental group; 20 B1 dogs and 18 B2 dogs) and 30 weight-matched adult healthy ASHs (control group) were used as subjects. There was no overlap for the ESWS/ESV-I ratio (0.83±0.03, range: 0.61-1.09 for B2 dogs, 1.34±0.05, range: 1.11-1.89 for B1 dogs, 2.17±0.0 range: 1.91-3.02 for the control dogs) among the groups. ESWS/ESV-I ratio (≤1.09) in ASHs with stage B2 DMVD may play a developmental role in left ventricular remodelling and risk factor for development of systolic dysfunction.

Evre B2 Dejeneratif Mitral Kapak Hastalığı Olan Anadolu Çoban Köpeklerinde Sistol-sonu Duvar Stresi/Sistol-sonu Hacim İndeks Oranı İle Sistolik Fonksiyonun Değerlendirilmesi

Bu çalışma, evre B2 dejeneratif mitral kapak hastalığı (DMVD) olan Anadolu çoban köpeklerinde (ASHs) sistol-sonu duvar stresi/sistol-sonu hacim indeks oranı (ESWS/ESV-I) ile sistolik fonksiyonu değerlendirmek için yapıldı. Çalışmada, DMVD’li 38 yetişkin ASHs (deney grubu; 20 B1 köpek ve 18 B2 köpek) ve 30 yetişkin sağlıklı ASHs (kontrol grubu) kullanıldı. Gruplar arasında ESWS/ESV-I oranı için (B2 köpeklerinde: 0.83±0.03, aralık: 0.61-1.09, B1 köpeklerinde 1.34±0.05, aralık: 1.11-1.89, kontrol köpeklerinde 2.17±0.0 aralık: 1.91-3.02) bir örtüşme yoktu. Evre B2 DMVD’li ASH’lerde, ESWS/ESV-I oranı (≤1.09) sol ventrikül yeniden yapılanması ve sistolik disfonksiyon gelişiminde risk faktörü olarak rol oynayabilir.

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