HAMDİ AVCI, SELİM SEKKİN, MURAT BOYACIOĞLU, HASAN AKŞİT, Recai TUNCA, E. Tuğrul EPİKMEN, S. Serap BİRİNCİOĞLU

Protective and Antigenotoxic Effects of Silymarin and Curcumin in Experimental Cyclophosphamide Intoxication in Rats [1]

Bu çalışmada, yüksek dozda siklofosfamid (CP) verilen ratların karaciğer ve böbrekler üzerindeki toksik etkilerine karşı kuvvetli antioksidan özellikleri bulunan silimarin (SLY) ve curcuminin (CUR) koruyucu etkileri araştırıldı. Bu amaçla çalışmada toplam 36 adet, ağırlıkları 250±10 gram olan erişkin Wistar albino ırkı dişi ratlar kullanıldı. Yalnızca CP verilen grupta biyokimyasal parametreler kontrol grubuna göre istatistiksel olarak anlamlı bir şekilde yüksek bulundu. CP ile birlikte eş zamanlı olarak SLY ve CUR verilen gruplarda biyokimyasal parametreler, yalnızca CP verilen gruba göre istatiksel olarak anlamlı bir şekilde düşük bulundu. Genotoksik incelemede comet parametreleri CP ile birlikte eş zamanlı SLY ve CUR verilen gruplarda ise yalnızca CP verilen gruba göre istatistiksel olarak anlamlı bir şekilde düşük bulundu. Çalışmada CP'nin toksik etkilerine karşı, kuvvetli antioksidan özelliklere sahip SLY ve CUR'un koruyucu alternatif birer kimyasal madde olarak kullanılabileceği görüldü.

Ratlarda Deneysel Siklofosfamid Toksikasyonunda Silimarin ve Curcuminin Koruyucu ve Antigenotoksik Etkileri

The aim of this study was to investigate the protective effects of silymarin (SLY) and curcumin (CUR), which have strong antioxidant properties, against the toxic effects of high dose of cyclophosphamide (CP) on the liver and kidneys of rats. For this purpose, a total of 36 adult Wistar albino female rats at the weight of, 250±10 g were used. Biochemical parameters were found to be significantly higher in the CP-only group than in the other groups. In the groups in which SLY and CUR were administered concurrently with CP, biochemical parameters were found to be significantly lower than in the CP-only group. In the SLY+CP and CUR+CP groups, biochemical parameters were correlated with the severity of histopathological findings. In genotoxic examination, the comet parameter levels in the SLY+CP and CUR+CP-treated groups were lower than those in the CP-treated group. The present study established that both SLY and CUR are effective against the toxic effects of high doses of CP.

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